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Urinary kidney inju...
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Carlsson, Axel CKarolinska Institutet,Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab,Centre for Family Medicine, Department of Neurobiology, Care Sciences, and Society, Karolinska Institute, Huddinge, Sweden; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden
(författare)
Urinary kidney injury molecule-1 and the risk of cardiovascular mortality in elderly men
- Artikel/kapitelEngelska2014
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LIBRIS-ID:oai:DiVA.org:du-14320
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https://urn.kb.se/resolve?urn=urn:nbn:se:du-14320URI
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https://doi.org/10.2215/CJN.11901113DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-228731URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:129490506URI
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Språk:engelska
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Sammanfattning på:engelska
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BACKGROUND AND OBJECTIVES: Kidney injury molecule-1 (KIM-1) has been suggested as a clinically relevant highly specific biomarker of acute kidney tubular damage. However, community-based data on the association between urinary levels of KIM-1 and the risk for cardiovascular mortality are lacking. This study aimed to investigate the association between urinary KIM-1 and cardiovascular mortality.DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: This was a prospective study, using the community-based Uppsala Longitudinal Study of Adult Men (N=590; mean age 77 years; baseline period, 1997-2001; median follow-up 8.1 years; end of follow-up, 2008).RESULTS: During follow-up, 89 participants died of cardiovascular causes (incidence rate, 2.07 per 100 person-years at risk). Models were adjusted for cardiovascular risk factors (age, systolic BP, diabetes, smoking, body mass index, total cholesterol, HDL cholesterol, antihypertensive treatment, lipid-lowering treatment, aspirin treatment, and history of cardiovascular disease) and for markers of kidney dysfunction and damage (cystatin C-based eGFR and urinary albumin/creatinine ratio). Higher urinary KIM-1/creatinine (from 24-hour urine collections) was associated with a higher risk for cardiovascular mortality (hazard ratio per SD increase, 1.27; 95% confidence interval [95% CI], 1.05 to 1.54; P=0.01). Participants with a combination of high KIM-1/creatinine (upper quintile, ≥175 ng/mmol), low eGFR (≤60 ml/min per 1.73 m(2)), and microalbuminuria/macroalbuminuria (albumin/creatinine ratio≥3 g/mol) had a >8-fold increased risk compared with participants with low KIM-1/creatinine (<175 ng/mmol), normal eGFR (>60 ml/min per 1.73 m(2)), and normoalbuminuria (albumin/creatinine ratio<3 g/mol) (hazard ratio, 8.56; 95% CI, 4.17 to 17.56; P<0.001).CONCLUSIONS: These findings suggest that higher urinary KIM-1 may predispose to a higher risk of cardiovascular mortality independently of established cardiovascular risk factors, eGFR, and albuminuria. Additional studies are needed to further assess the utility of measuring KIM-1 in the clinical setting.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Larsson, AndersUppsala universitet,Biokemisk struktur och funktion,Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden(Swepub:uu)andlarss
(författare)
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Helmersson-Karlqvist, JohannaUppsala universitet,Biokemisk struktur och funktion,Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden(Swepub:uu)johahelm
(författare)
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Lind, LarsUppsala universitet,Kardiovaskulär epidemiologi,Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden(Swepub:uu)larslind
(författare)
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Ingelsson, ErikUppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab,Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden(Swepub:uu)ering425
(författare)
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Larsson, Tobias EDepartment of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
(författare)
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Bottai, MatteoKarolinska Institutet,Division of Biostatistics, Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden
(författare)
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Sundström, JohanUppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab,Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden(Swepub:uu)johasund
(författare)
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Ärnlöv, Johan,1970-Uppsala universitet,Högskolan Dalarna,Medicinsk vetenskap,Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)johaarnl
(författare)
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Uppsala universitetMolekylär epidemiologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:American Society of Nephrology. Clinical Journal9:8, s. 1393-14011555-90411555-905X
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