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Targeted proteomic ...
Targeted proteomic analysis of habitual coffee consumption
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- Cornelis, Marilyn C (författare)
- Northwestern University Feinberg School of Medicine
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- Gustafsson, Stefan (författare)
- Uppsala University,Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab
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- Ärnlöv, Johan, 1970- (författare)
- Karolinska Institutet,Karolinska Institute,Dalarna University College,Högskolan Dalarna,Medicinsk vetenskap,Karolinska institutet
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- Elmståhl, S. (författare)
- Lund University,Lunds universitet,Geriatrik,Forskargrupper vid Lunds universitet,Geriatrics,Lund University Research Groups,Skåne University Hospital
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- Söderberg, Stefan (författare)
- Umeå University,Umeå universitet,Kardiologi
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- Sundström, Johan (författare)
- Uppsala universitet,Kardiovaskulär epidemiologi,Uppsala kliniska forskningscentrum (UCR)
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- Michaëlsson, Karl, 1959- (författare)
- Uppsala University,Uppsala universitet,Ortopedi
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- Lind, Lars (författare)
- Uppsala University,Uppsala universitet,Kardiovaskulär epidemiologi
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- Ingelsson, Erik, 1975- (författare)
- Uppsala University,Uppsala universitet,Molekylär epidemiologi,Stanford Univ, Sch Med, Dept Med, Div Cardiovasc Med, Stanford, CA 94305 USA,Stanford University
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(creator_code:org_t)
- 2017-11-16
- 2018
- Engelska.
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Ingår i: Journal of Internal Medicine. - : Wiley. - 0954-6820 .- 1365-2796. ; 283:2, s. 200-211
- Relaterad länk:
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https://onlinelibrar...
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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https://lup.lub.lu.s...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Coffee drinking has been implicated in mortality and a variety of diseases but potential mechanisms underlying these associations are unclear. Large-scale systems epidemiological approaches may offer novel insights to mechanisms underlying associations of coffee with health.OBJECTIVE: We performed an analysis of known and novel protein markers linked to cardiovascular disease and their association with habitual coffee intake in the Prospective Study of the Vasculature in Uppsala Seniors (PIVUS, n=816) and followed-up top proteins in the Uppsala Longitudinal Study of Adult Men (ULSAM, n=635) and EpiHealth (n=2418).METHODS: In PIVUS and ULSAM, coffee intake was measured by 7-day dietary records while a computer-based food frequency questionnaire was used in EpiHealth. Levels of up to 80 proteins were assessed in plasma by a proximity extension assay.RESULTS: Four protein-coffee associations adjusted for age, sex, smoking and BMI, met statistical significance in PIVUS (FDR<5%, P<2.31×10(-3) ): leptin (LEP), chitinase-3-like protein 1 (CHI3L), Tumor necrosis factor (TNF) receptor 6 and TNF-related apoptosis-inducing ligand. The inverse association between coffee intake and LEP replicated in ULSAM (β, -0.042 SD per cup of coffee, P=0.028) and EpiHealth (β, -0.025 SD per time of coffee, P=0.004). The negative coffee-CHI3L association replicated in EpiHealth (β, -0.07, P=1.15×10(-7) ), but not in ULSAM (β, -0.034, P=0.16).CONCLUSIONS: The current study supports an inverse association between coffee intake and plasma LEP and CHI3L1 levels. The coffee-CHI3L1 association is novel and warrants further investigation given links between CHI3L1 and health conditions that are also potentially influenced by coffee.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)
Nyckelord
- biomarkers
- coffee
- epidemiology
- population
- proteomics
- Hälsa och välfärd
- Health and Welfare
- biomarkers
- coffee
- epidemiology
- population
- proteomics
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Cornelis, Marily ...
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Gustafsson, Stef ...
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Ärnlöv, Johan, 1 ...
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Elmståhl, S.
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Söderberg, Stefa ...
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Sundström, Johan
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Michaëlsson, Kar ...
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Lind, Lars
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Ingelsson, Erik, ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Folkhälsovetensk ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Annan klinisk me ...
- Artiklar i publikationen
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Journal of Inter ...
- Av lärosätet
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Högskolan Dalarna
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Umeå universitet
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Uppsala universitet
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Lunds universitet
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Karolinska Institutet