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Dendritic cell matu...
Dendritic cell maturation in the corneal epithelium with onset of type 2 diabetes is associated with tumor necrosis factor receptor superfamily member 9
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- Lagali, Neil (author)
- Linköpings universitet,Linköping University,Sørlandet Hospital,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Ögonkliniken US,Sorlandet Hosp Arendal, Norway
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- Badian, Reza A (author)
- Oslo Univ Hosp, Dept Med Biochem, Unit Regenerat Med, N-0407 Oslo, Norway;Univ Oslo, N-0407 Oslo, Norway;Univ South Eastern Norway, Fac Visual & Hlth Sci, Natl Ctr Opt Vis & Eye Care, Kongsberg, Norway,University of Oslo,Oslo university hospital,University of South-Eastern Norway
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- Liu, Xu (author)
- Oyelegesenteret Tromso, Fjaerevegen 6, N-9024 Tomasjord, Norway
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- Feldreich, Tobias R (author)
- Uppsala University,Dalarna University College,Uppsala universitet,Institutionen för medicinska vetenskaper,Dalarna Univ, Sch Hlth & Social Sci, Falun, Sweden,Uppsala Univ, Sweden; Dalarna Univ, Sweden
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- Ärnlöv, Johan, 1970- (author)
- Karolinska Institute,Dalarna University College,Karolinska Institutet,Högskolan Dalarna,Medicinsk vetenskap,Karolinska institutet,Dalarna Univ, Sch Hlth & Social Sci, Falun, Sweden;Karolinska Inst, Div Family Med & Primary Care, Dept Neurobiol Care Sci & Soc, Huddinge, Sweden
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- Utheim, Tor Paaske (author)
- Oslo Univ Hosp, Dept Med Biochem, Unit Regenerat Med, N-0407 Oslo, Norway;Univ Oslo, N-0407 Oslo, Norway;Sorlandet Hosp Arendal, Dept Ophthalmol, Arendal, Norway,Sørlandet Hospital,University of Oslo,Oslo university hospital
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- Dahlin, Lars B. (author)
- Lund University,Lunds universitet,Handkirurgi, Malmö,Forskargrupper vid Lunds universitet,Hand Surgery, Malmö,Lund University Research Groups,Lund Univ, Sweden
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- Rolandsson, Olov (author)
- Umeå University,Umeå universitet,Allmänmedicin,Umea Univ, Dept Publ Hlth & Clin Med, Family Med, S-90187 Umea, Sweden
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(creator_code:org_t)
- 2018-09-24
- 2018
- English.
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In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 8:1
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Abstract
Subject headings
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- Type 2 diabetes mellitus is characterized by a low-grade inflammation; however, mechanisms leading to this inflammation in specific tissues are not well understood. The eye can be affected by diabetes; thus, we hypothesized that inflammatory changes in the eye may parallel the inflammation that develops with diabetes. Here, we developed a non-invasive means to monitor the status of inflammatory dendritic cell (DC) subsets in the corneal epithelium as a potential biomarker for the onset of inflammation in type 2 diabetes. In an age-matched cohort of 81 individuals with normal and impaired glucose tolerance and type 2 diabetes, DCs were quantified from wide-area maps of the corneal epithelial sub-basal plexus, obtained using clinical in vivo confocal microscopy (IVCM). With the onset of diabetes, the proportion of mature, antigen-presenting DCs increased and became organized in clusters. Out of 92 plasma proteins analysed in the cohort, tumor necrosis factor receptor super family member 9 (TNFRSF9) was associated with the observed maturation of DCs from an immature to mature antigen-presenting phenotype. A low-grade ocular surface inflammation observed in this study, where resident immature dendritic cells are transformed into mature antigen-presenting cells in the corneal epithelium, is a process putatively associated with TNFRSF9 signalling and may occur early in the development of type 2 diabetes. IVCM enables this process to be monitored non-invasively in the eye.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Oftalmologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Ophthalmology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- Hälsa och välfärd
- Health and Welfare
Publication and Content Type
- ref (subject category)
- art (subject category)
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