Longitudinal effects of aging on plasma proteins levels in older adults: associations with kidney function and hemoglobin levels

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Lind, LarsUppsala universitet,Klinisk epidemiologi (author)

Longitudinal effects of aging on plasma proteins levels in older adults : associations with kidney function and hemoglobin levels

Article/chapterEnglish2019

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2019-02-25
Public Library of Science (PLoS),2019
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LIBRIS-ID:oai:DiVA.org:du-29617
https://urn.kb.se/resolve?urn=urn:nbn:se:du-29617URI
https://doi.org/10.1371/journal.pone.0212060DOI
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-379592URI
http://kipublications.ki.se/Default.aspx?queryparsed=id:140428606URI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype

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BACKGROUND: A targeted proteomics chip has been shown to be useful to discover novel associations of proteins with cardiovascular disease. We investigated how these proteins change with aging, and whether this change is related to a decline in kidney function, or to a change in hemoglobin levels.MATERIAL AND METHODS: In the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study, including 1,016 participants from the general population aged 70 at baseline, 84 proteins were measured at ages 70, 75, 80. At these occasions, glomerular filtration rate (eGFR) was estimated and the hemoglobin levels were measured.RESULTS: Sixty-one of the 84 evaluated proteins changed significantly during the 10-year follow-up (multiple testing-adjusted alpha = 0.00059), most showing an increase. The change in eGFR was inversely related to changes of protein levels for the vast majority of proteins (74%). The change in hemoglobin was significantly related to the change in 40% of the evaluated proteins, with no obvious preference of the direction of these relationships.CONCLUSION: The majority of evaluated proteins increased with aging in adults. Therefore, normal ranges for proteins might be given in age-strata. The increase in protein levels was associated with the degree of reduction in eGFR for the majority of proteins, while no clear pattern was seen for the relationships between the proteins and the change in hemoglobin levels. Studies on changes in urinary proteins are warranted to understand the association between the reduction in eGFR and increase in plasma protein levels.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Klinisk laboratoriemedicin hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Clinical Laboratory Medicine hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Annan medicin och hälsovetenskap Gerontologi, medicinsk/hälsovetenskaplig inriktning hsv//swe
MEDICAL AND HEALTH SCIENCES Other Medical and Health Sciences Gerontology, specialising in Medical and Health Sciences hsv//eng
Hälsa och välfärd
Health and Welfare

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Sundström, Johan,Professor,1971-Uppsala universitet,Klinisk epidemiologi,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)johasund (author)
Larsson, AndersUppsala universitet,Anestesiologi och intensivvård,Hedenstiernalaboratoriet(Swepub:uu)andla606 (author)
Lampa, Erik,1977-Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)erila302 (author)
Ärnlöv, Johan,1970-Högskolan Dalarna,Medicinsk vetenskap,Karolinska Institutet,Dalarna Univ, Sch Hlth & Social Studies, Falun, Sweden;Karolinska Inst, Div Family Med, Dept Neurobiol Care Sci & Soc, Huddinge, Sweden(Swepub:du)jan (author)
Ingelsson, Erik,1975-Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab,Stanford Univ, Dept Med, Sch Med, Div Cardiovasc Med, Stanford, CA 94305 USA;Stanford Univ, Stanford Cardiovasc Inst, Stanford, CA 94305 USA;Stanford Univ, Stanford Diabet Res Ctr, Stanford, CA 94305 USA(Swepub:uu)ering425 (author)
Uppsala universitetKlinisk epidemiologi (creator_code:org_t)

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In:PLOS ONE: Public Library of Science (PLoS)14:21932-6203

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