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Sökning: onr:"swepub:oai:DiVA.org:du-29863" > Albuminuria as a pr...

  • Mok, Yejin (författare)

Albuminuria as a predictor of cardiovascular outcomes in patients with acute myocardial infarction

  • Artikel/kapitelEngelska2019

Förlag, utgivningsår, omfång ...

  • 2019
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:du-29863
  • https://urn.kb.se/resolve?urn=urn:nbn:se:du-29863URI
  • https://doi.org/10.1161/JAHA.118.010546DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:141771874URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Background. In patients with myocardial infarction ( MI ), reduced kidney function is recognized as an important predictor of poor prognosis, but the impact of albuminuria, a representative measure of kidney damage, has not been extensively evaluated.Methods and Results. In the SCREAM (Stockholm Creatinine Measurements) project (2006-2012), we identified 2469 patients with incident MI with dipstick proteinuria measured within a year before MI (427 patients also had urine albumin to creatinine ratio [ ACR ] measured concurrently) and obtained estimates for ACR with multiple imputation in participants with data solely on dipstick proteinuria. We quantified the association of ACR with the post- MI composite and individual outcomes of all-cause mortality, cardiovascular mortality, recurrent MI , ischemic stroke, or heart failure using Cox models and then evaluated the improvement in C statistic. During a median follow-up of 1.0 year after MI , 1607 participants (65.1%) developed the post- MI composite outcome. Higher ACR levels were independently associated with all outcomes except for ischemic stroke. Per 8-fold higher ACR (eg, 40 versus 5 mg/g), the hazard ratio of composite outcome was 1.21 (95% CI , 1.08-1.35). The addition of the ACR improved the C statistic of the post- MI composite by 0.040 (95% CI, 0.030-0.051). Largely similar results were obtained regardless of diabetic status and when ACR or dipstick was separately analyzed without imputation.Conclusions. In patients with MI , albuminuria was a potent predictor of subsequent outcomes, suggesting the importance of paying attention to the information on albuminuria, in addition to kidney function, in this high-risk population.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Ballew, Shoshana H (författare)
  • Sang, Yingying (författare)
  • Grams, Morgan EKarolinska Institutet (författare)
  • Coresh, Josef (författare)
  • Evans, Marie (författare)
  • Barany, PeterKarolinska Institutet (författare)
  • Ärnlöv, Johan,1970-Karolinska Institutet,Högskolan Dalarna,Medicinsk vetenskap,Karolinska institutet(Swepub:du)jan (författare)
  • Carrero, Juan-JesusKarolinska Institutet (författare)
  • Matsushita, Kunihiro (författare)
  • Karolinska InstitutetMedicinsk vetenskap (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of the American Heart Association8:82047-9980

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