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Growth differentiat...
Growth differentiation factor 15 (GDF-15) is a potential biomarker of both diabetic kidney disease and future cardiovascular events in cohorts of individuals with type 2 diabetes : a proteomics approach
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- Carlsson, Axel C (författare)
- Karolinska Institutet
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- Nowak, Christoph (författare)
- Karolinska Institutet
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- Lind, Lars (författare)
- Uppsala universitet,Klinisk epidemiologi,Uppsala Univ, Sweden
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- Östgren, Carl Johan, 1963- (författare)
- Linköpings universitet,Avdelningen för prevention, rehabilitering och nära vård,Medicinska fakulteten,Region Östergötland, Vårdcentralen Ödeshög
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- Nyström, Fredrik, 1963- (författare)
- Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Vårdcentralen Cityhälsan Centrum
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- Sundström, Johan, Professor, 1971- (författare)
- Uppsala universitet,Klinisk epidemiologi,Uppsala Univ, Sweden
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- Carrero, Juan Jesus (författare)
- Karolinska Institutet
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- Risérus, Ulf, 1967- (författare)
- Uppsala universitet,Klinisk nutrition och metabolism,Uppsala Univ, Sweden
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- Ingelsson, Erik, 1975- (författare)
- Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab,Stanford Univ, Dept Med, Sch Med, Div Cardiovasc Med, Stanford, CA 94305 USA;Stanford Univ, Stanford Cardiovasc Inst, Stanford, CA 94305 USA;Stanford Univ, Stanford Diabet Res Ctr, Stanford, CA 94305 USA,Stanford Univ, CA 94305 USA; Stanford Univ, CA 94305 USA; Stanford Univ, CA 94305 USA; Uppsala Univ, Sweden
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- Ärnlöv, Johan, 1970- (författare)
- Högskolan Dalarna,Medicinsk vetenskap,Karolinska Institutet,Karolinska Inst, Dept Neurobiol Care Sci & Soc NVS, Huddinge, Sweden;Dalarna Univ, Sch Hlth & Social Studies, Falun, Sweden
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- Fall, Tove, 1979- (författare)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär epidemiologi,Uppsala Univ, Sweden
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(creator_code:org_t)
- 2019-12-05
- 2020
- Engelska.
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Ingår i: Upsala Journal of Medical Sciences. - : Uppsala Medical Society. - 0300-9734 .- 2000-1967. ; 25:1, s. 37-43
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Background: Diabetic kidney disease (DKD) is a leading risk factor for end-stage renal disease and is one of the most important risk factors for cardiovascular disease in patients with diabetes. It is possible that novel markers portraying the pathophysiological underpinning processes may be useful.Aim: To investigate the associations between 80 circulating proteins, measured by a proximity extension assay, and prevalent DKD and major adverse cardiovascular events (MACE) in type 2 diabetes.Methods: We randomly divided individuals with type 2 diabetes from three cohorts into a two-thirds discovery and one-third replication set (total n = 813, of whom 231 had DKD defined by estimated glomerular filtration rate <60 mg/mL/1.73 m2 and/or urinary albumin-creatinine ratio ≥3 g/mol). Proteins associated with DKD were also assessed as predictors for incident major adverse cardiovascular events (MACE) in persons with DKD at baseline.Results: Four proteins were positively associated with DKD in models adjusted for age, sex, cardiovascular risk factors, glucose control, and diabetes medication: kidney injury molecule-1 (KIM-1, odds ratio [OR] per standard deviation increment, 1.65, 95% confidence interval [CI] 1.27-2.14); growth differentiation factor 15 (GDF-15, OR 1.40, 95% CI 1.16-1.69); myoglobin (OR 1.57, 95% CI 1.30-1.91), and matrix metalloproteinase 10 (MMP-10, OR 1.43, 95% CI 1.17-1.74). In patients with DKD, GDF-15 was significantly associated with increased risk of MACE after adjustments for baseline age, sex, microalbuminuria, and kidney function and (59 MACE events during 7 years follow-up, hazard ratio per standard deviation increase 1.43 [95% CI 1.03-1.98]) but not after further adjustments for cardiovascular risk factors.Conclusion: Our proteomics approach confirms and extends previous associations of higher circulating levels of GDF-15 with both micro- and macrovascular disease in patients with type 2 diabetes. Our data encourage additional studies evaluating the clinical utility of our findings.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- Albumin-creatinine ratio
- biomarker
- diabetic kidney disease
- glomerular filtration rate
- proteomics
- risk factor
- type 2 diabetes mellitus
- Hälsa och välfärd
- Health and Welfare
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Carlsson, Axel C
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Nowak, Christoph
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Lind, Lars
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Östgren, Carl Jo ...
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Nyström, Fredrik ...
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Sundström, Johan ...
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Carrero, Juan Je ...
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Risérus, Ulf, 19 ...
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Ingelsson, Erik, ...
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Ärnlöv, Johan, 1 ...
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Fall, Tove, 1979 ...
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MEDICIN OCH HÄLS ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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Högskolan Dalarna
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Uppsala universitet
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Linköpings universitet
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Karolinska Institutet