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  • Broberg, OlofLund University,Lunds universitet,Barnkardiologi,Forskargrupper vid Lunds universitet,Children cardiology,Lund University Research Groups,Skåne University Hospital (author)

Circulating leptin is associated with adverse vascular changes in young adult survivors of childhood cancer

  • Article/chapterEnglish2024

Publisher, publication year, extent ...

  • 2024
  • 2024
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:du-47982
  • https://urn.kb.se/resolve?urn=urn:nbn:se:du-47982URI
  • https://doi.org/10.1017/S1047951124000076DOI
  • https://lup.lub.lu.se/record/188755e3-6ddf-40f9-8514-cf51986b7141URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:154935405URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • INTRODUCTION: Proteomics may help discover novel biomarkers and underlying mechanisms for cardiovascular disease. This could be useful for childhood cancer survivors as they show an increased risk of cardiovascular disease. The aim of this study was to investigate circulating cardiovascular proteins in young adult survivors of childhood cancer and their relationship to previously reported subclinical cardiovascular disease.METHODS: Ninety-two cardiovascular proteins were measured in 57 childhood cancer survivors and in 52 controls. For proteins that were significantly different between childhood cancer survivors and controls, we performed correlations between protein levels and measures of peripheral arterial stiffness (carotid distensibility and stiffness index, and augmentation index) and endothelial dysfunction (reactive hyperemia index).RESULTS: Leptin was significantly higher in childhood cancer survivors compared to controls (normalized protein expression units: childhood cancer survivors 6.4 (1.5) versus 5.1 (1.7), p < 0.0000001) after taking multiple tests into account. Kidney injury molecule-1, MER proto-oncogene tyrosine kinase, selectin P ligand, decorin, alpha-1-microglobulin/bikunin precursor protein, and pentraxin 3 showed a trend towards group differences (p < 0.05). Among childhood cancer survivors, leptin was associated with anthracycline treatment after adjustment for age, sex, and body mass index (p < 0.0001). Higher leptin correlated with lower carotid distensibility after adjustment for age, sex, body mass index, and treatments with radiotherapy and anthracyclines (p = 0.005).CONCLUSION: This proteomics approach identified that leptin is higher in young asymptomatic adult survivors of childhood cancer than in healthy controls and is associated with adverse vascular changes. This could indicate a role for leptin in driving the cardiovascular disease burden in this population.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Feldreich, TobiasDalarna University College,Högskolan Dalarna,Medicinsk vetenskap(Swepub:du)trf (author)
  • Weismann, Constance G.Lund University,Lunds universitet,Barnkardiologi,Forskargrupper vid Lunds universitet,Children cardiology,Lund University Research Groups,Skåne University Hospital,Ludwig-Maximilian University of Munich(Swepub:lu)co7116we (author)
  • Øra, IngridLund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Childhood Cancer Research Unit,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital(Swepub:lu)molm-ior (author)
  • Wiebe, ThomasLund University,Lunds universitet,Sena effekter efter barncancerbehandling,Forskargrupper vid Lunds universitet,Late effects after childhood cancer treatment,Lund University Research Groups,Skåne University Hospital(Swepub:lu)pedi-twi (author)
  • Ärnlöv, Johan,1970-Karolinska Institute,Dalarna University College,Högskolan Dalarna,Medicinsk vetenskap,Karolinska Institutet, Huddinge(Swepub:du)jan (author)
  • Liuba, PetruLund University,Lunds universitet,Barnkardiologi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Children cardiology,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital(Swepub:lu)pedi-pli (author)
  • BarnkardiologiForskargrupper vid Lunds universitet (creator_code:org_t)

Related titles

  • In:Cardiology in the Young1047-95111467-1107

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