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Heart failure outco...
Heart failure outcomes by left ventricular ejection fraction in a contemporary region-wide patient cohort
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- Sundström, Johan (author)
- Uppsala University, Uppsala; University of New South Wales, Sydney, New South Wales, Australia
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- Ärnlöv, Johan, 1970- (author)
- Högskolan Dalarna,Medicinsk vetenskap,Karolinska Institutet, Huddinge
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- Karayiannides, Stelios (author)
- Karolinska Institutet
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- Bodegard, Johan (author)
- AstraZeneca, Gothenburg
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- Ersmark, Karolina (author)
- AstraZeneca, Stockholm
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- Gustafsson, Stefan (author)
- Sence Research AB, Uppsala
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- Cars, Thomas (author)
- Sence Research AB, Uppsala
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- Svensson, Maria K (author)
- Uppsala University, Uppsala
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- Norhammar, Anna (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2024
- 2024
- English.
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In: ESC Heart Failure. - 2055-5822. ; 11:3, s. 1377-1388
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https://doi.org/10.1...
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https://du.diva-port... (primary) (Raw object)
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Abstract
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- AIMS: This study aimed to characterize a contemporary population with subtypes of incident or prevalent heart failure (HF) based on reduced (HFrEF), mildly reduced, or preserved (HFpEF) left ventricular ejection fraction (LVEF) and to assess how outcomes, healthcare, treatments, and healthcare costs vary between each subtype of incident HF.METHODS AND RESULTS: Using Swedish data from the CardioRenal and Metabolic disease Heart Failure (CaReMe HF) study, updated to cover a more recent time period, this population-based study characterized patients from Stockholm County, Sweden, with incident HF (patients with a first HF diagnosis between 1 January 2015 and 31 December 2019) or prevalent HF (patients with a first HF diagnosis before 1 January 2020). Patients with incident HF had LVEF measured by echocardiography within ±90 days of their first HF diagnosis, and patients with prevalent HF within 5 years prior to the index date. The 13 375 patients with prevalent HF (39.2% women, mean age 73.9 years) had multiple comorbidities (cardiovascular diseases, chronic kidney disease, diabetes, and cancer). These were already highly prevalent at the time of the first HF diagnosis in the 8042 patients with incident HF (40.5% women, mean age 72.3 years). Patients with incident HFpEF received less specialist HF care at outpatient secondary care facilities following their first HF diagnosis than those with incident HFrEF. Patients with HFrEF had higher risks of complications and exerted a higher burden, in terms of care for and costs of HF, on the healthcare system.CONCLUSIONS: This study of contemporary patients with incident HF demonstrates that those with HFpEF and HFrEF differ considerably in terms of clinical presentation, prognosis, and care, highlighting a potential to improve HF outcomes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- HFmrEF
- HFpEF
- HFrEF
- Heart failure
- Left ventricular ejection fraction
Publication and Content Type
- ref (subject category)
- art (subject category)
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Sundström, Johan
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Ärnlöv, Johan, 1 ...
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Karayiannides, S ...
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Bodegard, Johan
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Ersmark, Karolin ...
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Gustafsson, Stef ...
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Cars, Thomas
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Svensson, Maria ...
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Norhammar, Anna
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
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ESC Heart Failur ...
- By the university
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Högskolan Dalarna
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Karolinska Institutet