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FEV1 and FVC as rob...
FEV1 and FVC as robust risk factors for cardiovascular disease and mortality : Insights from a large population study.
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- Rydell, Andreas (författare)
- Karolinska Institutet, Huddinge; Centrum För Klinisk Forskning, Region Dalarna, Falun,,Karolinska Inst, Dept Neurobiol Care Sci & Soc NVS, Div Family Med & Primary Care, Huddinge, Sweden.;Reg Dalarna, Ctr Klin Forskning, Falun, Sweden.;Karolinska Inst, Family Med Dept Neurobiol Care Sci & Soc, Alfred Nobels Alle 23,Plan 2, S-14183 Huddinge, Sweden.
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- Janson, Christer (författare)
- Uppsala universitet,Arbets- och miljömedicin,Lung- allergi- och sömnforskning
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- Lisspers, Karin, Docent, 1954- (författare)
- Uppsala universitet,Allmänmedicin och preventivmedicin
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- Lin, Yi-Ting (författare)
- Karolinska Institutet, Huddinge,Karolinska Inst, Dept Neurobiol Care Sci & Soc NVS, Div Family Med & Primary Care, Huddinge, Sweden.
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- Ärnlöv, Johan, 1970- (författare)
- Högskolan Dalarna,Medicinsk vetenskap,Karolinska Institutet, Huddinge; Centrum För Klinisk Forskning, Region Dalarna, Falun,Karolinska Inst, Dept Neurobiol Care Sci & Soc NVS, Div Family Med & Primary Care, Huddinge, Sweden.;Reg Dalarna, Ctr Klin Forskning, Falun, Sweden.;Dalarna Univ, Sch Hlth & Welf, Falun, Sweden.
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Karolinska Institutet, Huddinge; Centrum För Klinisk Forskning, Region Dalarna, Falun, Karolinska Inst, Dept Neurobiol Care Sci & Soc NVS, Div Family Med & Primary Care, Huddinge, Sweden;Reg Dalarna, Ctr Klin Forskning, Falun, Sweden.;Karolinska Inst, Family Med Dept Neurobiol Care Sci & Soc, Alfred Nobels Alle 23,Plan 2, S-14183 Huddinge, Sweden. (creator_code:org_t)
- Elsevier, 2024
- 2024
- Engelska.
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Ingår i: Respiratory Medicine. - : Elsevier. - 0954-6111 .- 1532-3064. ; 227
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Abstract
Ämnesord
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- INTRODUCTION: Data is limited on influence of forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) in a large adult population, including individuals with normal spirometry at baseline.METHODS: Using the UK Biobank cohort, a multivariable Cox regression analysis was conducted on 406,424 individuals to examine the association between FEV1 and FVC, categorized into three groups based on their percentage of predicted values (%pred) (≥80, 60-80 and < 60), and overall mortality, cardiovascular mortality, myocardial infarction, stroke, and heart failure over approximately 12.5 years. Moreover, a subgroup analysis was conducted on 295,459 individuals who had normal spirometry.RESULTS: Reduced FEV1 and FVC %pred values were associated with an elevated risk across all studied outcomes. Individuals with the lowest FEV1 and FVC %pred values (<60 %) exhibited HR of 1.83 (95 % CI 1.74-1.93) and 1.98 (95 % CI 1.76-2.22) for overall mortality, and 1.96 (95 % CI 1.83-2.1) and 2.26 (95 % CI 1.94-2.63) for cardiovascular mortality. Moreover, a graded association was observed between lower FEV1 and FVC %pred, even among never smokers and individuals with normal spirometry at baseline.DISCUSSION: Reduced FEV1 and FVC represent robust risk factors for cardiovascular disease and mortality. The fact that the increased risk was evident also at FEV1 and FVC levels exceeding 80 %pred challenges the contemporary classification of lung function categories and the notion that the entire FEV1- and FVC-range above 80 % of predicted represents a normal lung function.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Nyckelord
- Cardiovascular disease
- FEV(1)
- FVC
- Mortality
- Population attributable fraction
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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