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- Larsen, Filip,1977-Karolinska Institutet,Gymnastik- och idrottshögskolan,Björn Ekbloms forskningsgrupp (author)
Dietary inorganic nitrate improves mitochondrial efficiency in humans.
- Article/chapterEnglish2011
Publisher, publication year, extent ...
- Elsevier BV,2011
- printrdacarrier
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- LIBRIS-ID:oai:DiVA.org:gih-1805
- https://urn.kb.se/resolve?urn=urn:nbn:se:gih:diva-1805URI
- https://doi.org/10.1016/j.cmet.2011.01.004DOI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:121992496URI
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- Language:English
- Summary in:English
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- SwePubSwePub
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Notes
- Nitrate, an inorganic anion abundant in vegetables, is converted in vivo to bioactive nitrogen oxides including NO. We recently demonstrated that dietary nitrate reduces oxygen cost during physical exercise, but the mechanism remains unknown. In a double-blind crossover trial we studied the effects of a dietary intervention with inorganic nitrate on basal mitochondrial function and whole-body oxygen consumption in healthy volunteers. Skeletal muscle mitochondria harvested after nitrate supplementation displayed an improvement in oxidative phosphorylation efficiency (P/O ratio) and a decrease in state 4 respiration with and without atractyloside and respiration without adenylates. The improved mitochondrial P/O ratio correlated to the reduction in oxygen cost during exercise. Mechanistically, nitrate reduced the expression of ATP/ADP translocase, a protein involved in proton conductance. We conclude that dietary nitrate has profound effects on basal mitochondrial function. These findings may have implications for exercise physiology- and lifestyle-related disorders that involve dysfunctional mitochondria.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Fysiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Physiology hsv//eng
- Physiology
- Fysiologi
- Medicin/Teknik
- Medicine/Technology
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- Schiffer, TAKarolinska Institutet (author)
- Borniquel, SKarolinska Institutet (author)
- Sahlin, KentGymnastik- och idrottshögskolan,Forskningsgruppen Mitokondriell funktion och metabol kontroll(Swepub:gih)kents (author)
- Ekblom, BjörnGymnastik- och idrottshögskolan,Björn Ekbloms forskningsgrupp(Swepub:gih)bjorne (author)
- Lundberg, JOKarolinska Institutet (author)
- Weitzberg, EKarolinska Institutet (author)
- Gymnastik- och idrottshögskolanBjörn Ekbloms forskningsgrupp (creator_code:org_t)
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- In:Cell Metabolism: Elsevier BV13:2, s. 149-1591550-41311932-7420
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