Immunological Alterations Used to Predict Infections in Response to Strenuous Physical Training

• ABSTRACT The aim of this study was to screen leukocyte cell surface markers to identify possible predictors for infection related to physical training. Ten healthy soldiers (mean age, 19.1; mean body mass, 77.4 kg; mean VO ^sub 2^ peak, 4.54 L min ^sup -1^ /58.6 mL min ^sup -1^ kg ^sup -1^ ) were included. Blood samples were collected and number of infections recorded before and after a 6-day training course. White blood cell distributions and expression of surface receptors changed during training. Before training, expression of CD3 on CD8  lymphocytes and percent CD8 CD3 lymphocytes was lower, whereas CD4/CD8 ratio was higher among subjects who failed compared to those who completed the training. A subclinical infection before the start of the military training may alter the CD4/CD8 ratio. Prediction of future infections may be possible from pre-exercise immunological status, fi ndings useful in military settings and exercise, where sudden infections may result in severe consequences.  

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Medicine/Technology

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