Blood Pressure-Lowering Effect of Orally Ingested Nitrite Is Abolished by a Proton Pump Inhibitor.

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: id:"swepub:oai:DiVA.org:gih-4638" > Blood Pressure-Lowe...

1 of 1
Previous record
Next record
To hitlist

Details
MARC

Montenegro, Marcelo F (author)

Blood Pressure-Lowering Effect of Orally Ingested Nitrite Is Abolished by a Proton Pump Inhibitor.

Article/chapterEnglish2017

Publisher, publication year, extent ...

2017
printrdacarrier

Numbers

LIBRIS-ID:oai:DiVA.org:gih-4638
https://urn.kb.se/resolve?urn=urn:nbn:se:gih:diva-4638URI
https://doi.org/10.1161/HYPERTENSIONAHA.116.08081DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:134823573URI

Supplementary language notes

Language:English
Summary in:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Inorganic nitrate and nitrite from dietary and endogenous sources are metabolized to NO and other bioactive nitrogen oxides that affect blood pressure. The mechanisms for nitrite bioactivation are unclear, but recent studies in rodents suggest that gastric acidity may influence the systemic effects of this anion. In a randomized, double-blind, placebo-controlled crossover study, we tested the effects of a proton pump inhibitor on the acute cardiovascular effects of nitrite. Fifteen healthy nonsmoking, normotensive subjects, aged 19 to 39 years, were pretreated with placebo or esomeprazole (3×40 mg) before ingesting sodium nitrite (0.3 mg kg(-1)), followed by blood pressure monitoring. Nitrite reduced systolic blood pressure by a maximum of 6±1.3 mm Hg when taken after placebo, whereas pretreatment with esomeprazole blunted this effect. Peak plasma nitrite, nitrate, and nitroso species levels after nitrite ingestion were similar in both interventions. In 8 healthy volunteers, we then infused increasing doses of sodium nitrite (1, 10, and 30 nmol kg(-1) min(-1)) intravenously. Interestingly, although plasma nitrite peaked at similar levels as with orally ingested nitrite (≈1.8 µmol/L), no changes in blood pressure were observed. In rodents, esomeprazole did not affect the blood pressure response to the NO donor, DEA NONOate, or vascular relaxation to nitroprusside and acetylcholine, demonstrating an intact downstream NO-signaling pathway. We conclude that the acute blood pressure-lowering effect of nitrite requires an acidic gastric environment. Future studies will reveal if the cardiovascular complications associated with the use of proton pump inhibitors are linked to interference with the nitrate-nitrite-NO pathway.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Fysiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Physiology hsv//eng
Medicin/Teknik
Medicine/Technology

Added entries (persons, corporate bodies, meetings, titles ...)

Sundqvist, Michaela LKarolinska Institutet (author)
Larsen, Filip JKarolinska Institutet,Gymnastik- och idrottshögskolan,Forskningsgruppen Mitokondriell funktion och metabol kontroll(Swepub:gih)filipl (author)
Zhuge, Zhengbing (author)
Carlström, MattiasKarolinska Institutet (author)
Weitzberg, EddieKarolinska Institutet (author)
Lundberg, Jon OKarolinska Institutet (author)
Karolinska InstitutetForskningsgruppen Mitokondriell funktion och metabol kontroll (creator_code:org_t)

Related titles

In:Hypertension69:1, s. 23-310194-911X1524-4563

Internet link

Find in a library

Hypertension (Search for host publication in LIBRIS)

To the university's database

1 of 1
Previous record
Next record
To hitlist

Find more in SwePub

By the author/editor: Montenegro, Marc ...; Sundqvist, Micha ...; Larsen, Filip J; Zhuge, Zhengbing; Carlström, Matti ...; Weitzberg, Eddie; show more...; Lundberg, Jon O; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Physiology

Articles in the publication: Hypertension

By the university: The Swedish School of Sport and Health Sciences; Karolinska Institutet

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se