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Regulation of UCP2 ...
Regulation of UCP2 and UCP3 by muscle disuse and physical activity in tetraplegic subjects.
- Artikel/kapitelEngelska1999
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Springer Science and Business Media LLC,1999
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LIBRIS-ID:oai:DiVA.org:gih-5023
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https://urn.kb.se/resolve?urn=urn:nbn:se:gih:diva-5023URI
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https://doi.org/10.1007/s001250051233DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:1947144URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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AIMS/HYPOTHESIS: The regulation of uncoupling protein 2 and uncoupling protein 3 gene expression in skeletal muscle has recently been the focus of intense interest. Our aim was to determine expression of uncoupling protein 2 and 3 in skeletal muscle from tetraplegic subjects, a condition representing profound muscle inactivity. Thereafter we determined whether exercise training would modify expression of these genes in skeletal muscle.METHODS: mRNA expression of uncoupling protein 2 and 3 was determined using quantitative reverse transcription-polymerase chain-reaction.RESULTS: Expression of uncoupling protein 2 and 3 mRNA was increased in skeletal muscle from tetraplegic compared with able-bodied subjects (3.7-fold p < 0.01 and 4.1-fold, p < 0.05, respectively). A subgroup of four tetraplegic subjects underwent an 8-week exercise programme consisting of electrically-stimulated leg cycling (ESLC, 7 ESLC sessions/week). This training protocol leads to increases in whole body insulin-stimulated glucose uptake and expression of genes involved in glucose metabolism in skeletal muscle from tetraplegic subjects. After ESLC training, uncoupling protein 2 expression was reduced by 62% and was similar to that in able-bodied people. Similarly, ESLC training was associated with a reduction of uncoupling protein 3 expression in skeletal muscle from three of four tetraplegic subjects, however, post-exercise levels remained increased compared with able-bodied subjects.CONCLUSION/INTERPRETATION: Tetraplegia is associated with increased mRNA expression of uncoupling protein 2 and 3 in skeletal muscle. Exercise training leads to normalisation of uncoupling protein 2 expression in tetraplegic subjects. Muscle disuse and physical activity appear to be powerful regulators of uncoupling protein 2 and 3 expression in human skeletal muscle.
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Fernström, MariaKarolinska Institutet(Swepub:gih)mariaf
(författare)
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Zierath, J RKarolinska Institutet
(författare)
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Krook, AKarolinska Institutet
(författare)
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Karolinska Institutet
(creator_code:org_t)
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Ingår i:Diabetologia: Springer Science and Business Media LLC42:7, s. 826-300012-186X1432-0428
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