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  • Freak-Poli, RosanneDepartment of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia (författare)

Loneliness, Not Social Support, Is Associated with Cognitive Decline and Dementia Across Two Longitudinal Population-Based Cohorts

  • Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

  • IOS Press,2022
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:gih-6866
  • https://urn.kb.se/resolve?urn=urn:nbn:se:gih:diva-6866URI
  • https://doi.org/10.3233/jad-210330DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Background: Poor social health is likely associated with cognitive decline and risk of dementia; however, studies show inconsistent results. Additionally, few studies separate social health components or control for mental health.Objective: To investigate whether loneliness and social support are independently associated with cognitive decline and risk of dementia, and whether depressive symptoms confound the association.Methods: We included 4,514 participants from the population-based Rotterdam Study (RS; aged 71±7SD years) followed up to 14 years (median 10.8, interquartile range 7.4-11.6), and 2,112 participants from the Swedish National Study on Aging and Care in Kungsholmen (SNAC-K; aged 72±10SD years) followed up to 10 years (mean 5.9±1.6SD). At baseline, participants were free of major depression and scored on the Mini-Mental State Examination (MMSE) ≥26 for RS and ≥25 for SNAC-K. We investigated loneliness, perceived social support, and structural social support (specifically marital status and number of children). In both cohorts, dementia was diagnosed and cognitive function was repeatedly assessed with MMSE and a global cognitive factor (g-factor).Results: Loneliness was prospectively associated with a decline in the MMSE in both cohorts. Consistently, persons who were lonely had an increased risk of developing dementia (RS: HR 1.34, 95%CI 1.08-1.67; SNAC-K: HR 2.16, 95%CI 1.12-4.17). Adjustment for depressive symptoms and exclusion of the first 5 years of follow-up did not alter results. Neither perceived or structural social support was associated with cognitive decline or dementia risk.Conclusion: Loneliness, not social support, predicted cognitive decline and incident dementia independently of depressive symptoms.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Wagemaker, NinaDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands (författare)
  • Wang, RuiGymnastik- och idrottshögskolan,Institutionen för fysisk aktivitet och hälsa,Aging Research Center, Karolinska Institute, Stockholm, Sweden,Fysisk aktivitet och hjärnhälsa(Swepub:gih)rui.wang (författare)
  • Lysen, Thom S.Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands (författare)
  • Ikram, M. ArfanDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands;Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands;Department of Radiology, Erasmus Medical Center, Rotterdam, The Netherlands (författare)
  • Vernooij, Meike W.Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands;Department of Radiology, Erasmus Medical Center, Rotterdam, The Netherlands (författare)
  • Dintica, Christina S.Aging Research Center, Karolinska Institute, Stockholm, Sweden (författare)
  • Vernooij-Dassen, MyrraRadboud University Medical Center, IQ Healthcare, Nijmegen, The Netherlands (författare)
  • Melis, Rene J.M.Department of Geriatric Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands (författare)
  • Laukka, Erica J.Aging Research Center, Karolinska Institute, Stockholm, Sweden (författare)
  • Fratiglioni, LauraAging Research Center, Karolinska Institute, Stockholm, Sweden (författare)
  • Xu, WeiliAging Research Center, Karolinska Institute, Stockholm, Sweden (författare)
  • Tiemeier, HenningDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands;Department of Social and Behavioral Science, Harvard TH Chan School of Public Health, Boston, MA, USA (författare)
  • Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, AustraliaDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of Alzheimer's Disease: IOS Press85:1, s. 295-3081387-28771875-8908

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