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Prevalence of Subcl...
Prevalence of Subclinical Coronary Artery Atherosclerosis in the General Population
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- Bergström, Göran (author)
- Department of Molecular and Clinical Medicine (G. Bergström, E.B., O.A., B.F., O.H., A.R.), University of Gothenburg, Sweden.;Departments of Clinical Physiology (G. Bergström, O.H.), Region Västra Götaland, Gothenburg, Sweden.
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- Persson, Margaretha (author)
- Department of Clinical Sciences (M.P., G. Berglund, G.E., M. Magnusson), Lund University, Malmö, Sweden.;Departments of Internal Medicine (M.P.), Skåne University Hospital, Malmö, Sweden.
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- Adiels, Martin (author)
- Sahlgrenska Academy, and School of Public Health and Community Medicine, Institute of Medicine (M.A., C.B.), University of Gothenburg, Sweden.
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- Björnson, Elias (author)
- Department of Molecular and Clinical Medicine (G. Bergström, E.B., O.A., B.F., O.H., A.R.), University of Gothenburg, Sweden.
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- Bonander, Carl (author)
- Sahlgrenska Academy, and School of Public Health and Community Medicine, Institute of Medicine (M.A., C.B.), University of Gothenburg, Sweden.
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- Ahlström, Håkan (author)
- Section of Radiology, Department of Surgical Sciences (H.A., O.D.), Uppsala University, Sweden.
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- Alfredsson, Joakim (author)
- Departments of Cardiology (J.A., E.S.), Linköping University, Sweden.;Health, Medicine and Caring Sciences (J.A., E.S., J.E.E., F.H.N., C.J.Ö., A.P.), Linköping University, Sweden.
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- Angerås, Oskar (author)
- Department of Molecular and Clinical Medicine (G. Bergström, E.B., O.A., B.F., O.H., A.R.), University of Gothenburg, Sweden.;Cardiology (O.A.), Region Västra Götaland, Gothenburg, Sweden.
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- Berglund, Göran (author)
- Department of Clinical Sciences (M.P., G. Berglund, G.E., M. Magnusson), Lund University, Malmö, Sweden.
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- Blomberg, Anders (author)
- Department of Public Health and Clinical Medicine, Medicine and Heart Centre (A.B., J.L., A. Sandström, A. Själander, S.S.), Umeå University, Sweden.
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- Brandberg, John (author)
- Department of Radiology, Institute of Clinical Sciences (J.B., E.F., A.F.), University of Gothenburg, Sweden.;Radiology (J.B., E.F., A.F.), Region Västra Götaland, Gothenburg, Sweden.
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- Börjesson, Mats (author)
- Institute of Medicine (M.B.), University of Gothenburg, Sweden.;Center for Health and Performance (M.B.), University of Gothenburg, Sweden.;Sahlgrenska University Hospital (M.B., B.F., A.R., K.T.), Region Västra Götaland, Gothenburg, Sweden.
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- Cederlund, Kerstin (author)
- Department of Clinical Science, Intervention and Technology (K.C.), Karolinska Institutet, Stockholm, Sweden.
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- de Faire, Ulf (author)
- Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine (U.d.F.), Karolinska Institutet, Stockholm, Sweden.
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- Duvernoy, Olov (author)
- Section of Radiology, Department of Surgical Sciences (H.A., O.D.), Uppsala University, Sweden.
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- Ekblom, Örjan, 1971- (author)
- Gymnastik- och idrottshögskolan,Institutionen för fysisk aktivitet och hälsa
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- Engström, Gunnar (author)
- Department of Clinical Sciences (M.P., G. Berglund, G.E., M. Magnusson), Lund University, Malmö, Sweden.
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- Engvall, Jan E. (author)
- Health, Medicine and Caring Sciences (J.A., E.S., J.E.E., F.H.N., C.J.Ö., A.P.), Linköping University, Sweden.;Clinical Physiology (J.E.E.), Linköping University, Sweden.;CMIV, Centre of Medical Image Science and Visualization (J.E.E., A.P., C.J.Ö.), Linköping University, Sweden.
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- Fagman, Erika (author)
- Department of Radiology, Institute of Clinical Sciences (J.B., E.F., A.F.), University of Gothenburg, Sweden.;Radiology (J.B., E.F., A.F.), Region Västra Götaland, Gothenburg, Sweden.
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- Eriksson, Mats (author)
- Department of Endocrinology, Metabolism & Diabetes and Clinical Research Center, Karolinska University Hospital Huddinge, Stockholm, Sweden (M.E.).
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- Erlinge, David (author)
- Department of Clinical Sciences Lund, Cardiology, Lund University and Skåne University Hospital, Lund, Sweden (D.E., M.A.M.).
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- Fagerberg, Björn (author)
- Department of Molecular and Clinical Medicine (G. Bergström, E.B., O.A., B.F., O.H., A.R.), University of Gothenburg, Sweden.;Sahlgrenska University Hospital (M.B., B.F., A.R., K.T.), Region Västra Götaland, Gothenburg, Sweden.
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- Flinck, Agneta (author)
- Department of Radiology, Institute of Clinical Sciences (J.B., E.F., A.F.), University of Gothenburg, Sweden.;Radiology (J.B., E.F., A.F.), Region Västra Götaland, Gothenburg, Sweden.
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- Gonçalves, Isabel (author)
- Department of Clinical Sciences Malmö (I.G.), Lund University and Skåne University Hospital, Lund, Sweden.
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- Hagström, Emil (author)
- Cardiology (E.H.), Uppsala University, Sweden.;Department of Medical Sciences, and Uppsala Clinical Research Center (E.H.), Uppsala University, Sweden.
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- Hjelmgren, Ola (author)
- Department of Molecular and Clinical Medicine (G. Bergström, E.B., O.A., B.F., O.H., A.R.), University of Gothenburg, Sweden.;Departments of Clinical Physiology (G. Bergström, O.H.), Region Västra Götaland, Gothenburg, Sweden.
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- Lind, Lars (author)
- Clinical Epidemiology (L.L., J.S.), Uppsala University, Sweden.
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- Lindberg, Eva (author)
- Respiratory, Allergy and Sleep Research (E.L.), Uppsala University, Sweden.
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- Lindqvist, Per (author)
- Department of Surgical and Perioperative Sciences (P.L.), Umeå University, Sweden.
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- Ljungberg, Johan (author)
- Department of Public Health and Clinical Medicine, Medicine and Heart Centre (A.B., J.L., A. Sandström, A. Själander, S.S.), Umeå University, Sweden.
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- Magnusson, Martin (author)
- Department of Clinical Sciences (M.P., G. Berglund, G.E., M. Magnusson), Lund University, Malmö, Sweden.;Cardiology (M. Magnusson), Skåne University Hospital, Malmö, Sweden.;Wallenberg Center for Molecular Medicine, Lund University, Sweden (M. Magnusson).;North-West University, Hypertension in Africa Research Team (HART), Potchefstroom, South Africa (M. Magnusson).
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- Mannila, Maria (author)
- Heart and Vascular Theme, Department of Cardiology, and Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden (M. Mannila).
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- Markstad, Hanna (author)
- Experimental Cardiovascular Research, Clinical Research Center, Clinical Sciences Malmö (H.M.), Lund University, Malmö, Sweden.;Center for Medical Imaging and Physiology (H.M.), Lund University and Skåne University Hospital, Lund, Sweden.
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- Mohammad, Moman A. (author)
- Department of Clinical Sciences Lund, Cardiology, Lund University and Skåne University Hospital, Lund, Sweden (D.E., M.A.M.).
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- Nystrom, Fredrik H. (author)
- Health, Medicine and Caring Sciences (J.A., E.S., J.E.E., F.H.N., C.J.Ö., A.P.), Linköping University, Sweden.
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- Ostenfeld, Ellen (author)
- Department of Clinical Sciences Lund, Clinical Physiology (E.O.), Lund University and Skåne University Hospital, Lund, Sweden.
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- Persson, Anders (author)
- Health, Medicine and Caring Sciences (J.A., E.S., J.E.E., F.H.N., C.J.Ö., A.P.), Linköping University, Sweden.;Radiology (A.P.), Linköping University, Sweden.;CMIV, Centre of Medical Image Science and Visualization (J.E.E., A.P., C.J.Ö.), Linköping University, Sweden.
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- Rosengren, Annika (author)
- Department of Molecular and Clinical Medicine (G. Bergström, E.B., O.A., B.F., O.H., A.R.), University of Gothenburg, Sweden.;Sahlgrenska University Hospital (M.B., B.F., A.R., K.T.), Region Västra Götaland, Gothenburg, Sweden.
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- Sandström, Anette (author)
- Department of Public Health and Clinical Medicine, Medicine and Heart Centre (A.B., J.L., A. Sandström, A. Själander, S.S.), Umeå University, Sweden.
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- Själander, Anders (author)
- Department of Public Health and Clinical Medicine, Medicine and Heart Centre (A.B., J.L., A. Sandström, A. Själander, S.S.), Umeå University, Sweden.
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- Sköld, Magnus C. (author)
- Respiratory Medicine Unit, Department of Medicine Solna and Center for Molecular Medicine (M.C.S.), Karolinska Institutet, Stockholm, Sweden.;Department of Respiratory Medicine and Allergy, Karolinska University Hospital Solna, Stockholm, Sweden (M.C.S.).
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- Sundström, Johan (author)
- Clinical Epidemiology (L.L., J.S.), Uppsala University, Sweden.;The George Institute for Global Health, University of New South Wales, Sydney, Australia (J.S.).
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- Swahn, Eva (author)
- Departments of Cardiology (J.A., E.S.), Linköping University, Sweden.;Health, Medicine and Caring Sciences (J.A., E.S., J.E.E., F.H.N., C.J.Ö., A.P.), Linköping University, Sweden.
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- Söderberg, Stefan (author)
- Department of Public Health and Clinical Medicine, Medicine and Heart Centre (A.B., J.L., A. Sandström, A. Själander, S.S.), Umeå University, Sweden.
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- Torén, Kjell (author)
- Occupational and Environmental Medicine/School of Public Health and Community Medicine (K.T.), University of Gothenburg, Sweden.;Sahlgrenska University Hospital (M.B., B.F., A.R., K.T.), Region Västra Götaland, Gothenburg, Sweden.
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- Östgren, Carl Johan (author)
- Health, Medicine and Caring Sciences (J.A., E.S., J.E.E., F.H.N., C.J.Ö., A.P.), Linköping University, Sweden.;CMIV, Centre of Medical Image Science and Visualization (J.E.E., A.P., C.J.Ö.), Linköping University, Sweden.
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- Jernberg, Tomas (author)
- Department of Clinical Sciences, Danderyd University Hospital (T.J.), Karolinska Institutet, Stockholm, Sweden.
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Department of Molecular and Clinical Medicine (G Bergström, E.B., O.A., B.F., O.H., A.R.), University of Gothenburg, Sweden.;Departments of Clinical Physiology (G. Bergström, O.H.), Region Västra Götaland, Gothenburg, Sweden. Department of Clinical Sciences (M.P., G. Berglund, G.E., M. Magnusson), Lund University, Malmö, Sweden.;Departments of Internal Medicine (M.P.), Skåne University Hospital, Malmö, Sweden. (creator_code:org_t)
- Wolters Kluwer, 2021
- 2021
- English.
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In: Circulation. - : Wolters Kluwer. - 0009-7322 .- 1524-4539. ; 144:12, s. 916-929
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Abstract
Subject headings
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- Background: Early detection of coronary atherosclerosis using coronary computed tomography angiography (CCTA), in addition to coronary artery calcification (CAC) scoring, may help inform prevention strategies. We used CCTA to determine the prevalence, severity, and characteristics of coronary atherosclerosis and its association with CAC scores in a general population.Methods: We recruited 30 154 randomly invited individuals age 50 to 64 years to SCAPIS (the Swedish Cardiopulmonary Bioimage Study). The study includes individuals without known coronary heart disease (ie, no previous myocardial infarctions or cardiac procedures) and with high-quality results from CCTA and CAC imaging performed using dedicated dual-source CT scanners. Noncontrast images were scored for CAC. CCTA images were visually read and scored for coronary atherosclerosis per segment (defined as no atherosclerosis, 1% to 49% stenosis, or ≥50% stenosis). External validity of prevalence estimates was evaluated using inverse probability for participation weighting and Swedish register data.Results: In total, 25 182 individuals without known coronary heart disease were included (50.6% women). Any CCTA-detected atherosclerosis was found in 42.1%; any significant stenosis (≥50%) in 5.2%; left main, proximal left anterior descending artery, or 3-vessel disease in 1.9%; and any noncalcified plaques in 8.3% of this population. Onset of atherosclerosis was delayed on average by 10 years in women. Atherosclerosis was more prevalent in older individuals and predominantly found in the proximal left anterior descending artery. Prevalence of CCTA-detected atherosclerosis increased with increasing CAC scores. Among those with a CAC score >400, all had atherosclerosis and 45.7% had significant stenosis. In those with 0 CAC, 5.5% had atherosclerosis and 0.4% had significant stenosis. In participants with 0 CAC and intermediate 10-year risk of atherosclerotic cardiovascular disease according to the pooled cohort equation, 9.2% had CCTA-verified atherosclerosis. Prevalence estimates had excellent external validity and changed marginally when adjusted to the age-matched Swedish background population.Conclusions: Using CCTA in a large, random sample of the general population without established disease, we showed that silent coronary atherosclerosis is common in this population. High CAC scores convey a significant probability of substantial stenosis, and 0 CAC does not exclude atherosclerosis, particularly in those at higher baseline risk.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- coronary angiography
- coronary artery disease
- epidemiology
- plaque
- atherosclerotic
- primary prevention
- tomography.
- Medicin/Teknik
- Medicine/Technology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Bergström, Göran
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Persson, Margare ...
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Adiels, Martin
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Björnson, Elias
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Bonander, Carl
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Ahlström, Håkan
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Alfredsson, Joak ...
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Angerås, Oskar
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Berglund, Göran
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Blomberg, Anders
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Brandberg, John
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Börjesson, Mats
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Cederlund, Kerst ...
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de Faire, Ulf
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Duvernoy, Olov
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Ekblom, Örjan, 1 ...
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Engström, Gunnar
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Engvall, Jan E.
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Fagman, Erika
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Eriksson, Mats
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Erlinge, David
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Fagerberg, Björn
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Flinck, Agneta
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Gonçalves, Isabe ...
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Hagström, Emil
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Hjelmgren, Ola
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Lind, Lars
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Lindberg, Eva
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Lindqvist, Per
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Ljungberg, Johan
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Magnusson, Marti ...
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Mannila, Maria
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Markstad, Hanna
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Mohammad, Moman ...
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Nystrom, Fredrik ...
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Ostenfeld, Ellen
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Persson, Anders
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Rosengren, Annik ...
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Sandström, Anett ...
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Själander, Ander ...
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Sköld, Magnus C.
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Sundström, Johan
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Swahn, Eva
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Söderberg, Stefa ...
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Torén, Kjell
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Östgren, Carl Jo ...
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Jernberg, Tomas
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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Circulation
- By the university
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The Swedish School of Sport and Health Sciences