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Prevalence of Subcl...
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Bergström, GöranDepartment of Molecular and Clinical Medicine (G. Bergström, E.B., O.A., B.F., O.H., A.R.), University of Gothenburg, Sweden.;Departments of Clinical Physiology (G. Bergström, O.H.), Region Västra Götaland, Gothenburg, Sweden.
(författare)
Prevalence of Subclinical Coronary Artery Atherosclerosis in the General Population
- Artikel/kapitelEngelska2021
Förlag, utgivningsår, omfång ...
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Wolters Kluwer,2021
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:gih-6892
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https://urn.kb.se/resolve?urn=urn:nbn:se:gih:diva-6892URI
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https://doi.org/10.1161/circulationaha.121.055340DOI
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Språk:engelska
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Sammanfattning på:engelska
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Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Background: Early detection of coronary atherosclerosis using coronary computed tomography angiography (CCTA), in addition to coronary artery calcification (CAC) scoring, may help inform prevention strategies. We used CCTA to determine the prevalence, severity, and characteristics of coronary atherosclerosis and its association with CAC scores in a general population.Methods: We recruited 30 154 randomly invited individuals age 50 to 64 years to SCAPIS (the Swedish Cardiopulmonary Bioimage Study). The study includes individuals without known coronary heart disease (ie, no previous myocardial infarctions or cardiac procedures) and with high-quality results from CCTA and CAC imaging performed using dedicated dual-source CT scanners. Noncontrast images were scored for CAC. CCTA images were visually read and scored for coronary atherosclerosis per segment (defined as no atherosclerosis, 1% to 49% stenosis, or ≥50% stenosis). External validity of prevalence estimates was evaluated using inverse probability for participation weighting and Swedish register data.Results: In total, 25 182 individuals without known coronary heart disease were included (50.6% women). Any CCTA-detected atherosclerosis was found in 42.1%; any significant stenosis (≥50%) in 5.2%; left main, proximal left anterior descending artery, or 3-vessel disease in 1.9%; and any noncalcified plaques in 8.3% of this population. Onset of atherosclerosis was delayed on average by 10 years in women. Atherosclerosis was more prevalent in older individuals and predominantly found in the proximal left anterior descending artery. Prevalence of CCTA-detected atherosclerosis increased with increasing CAC scores. Among those with a CAC score >400, all had atherosclerosis and 45.7% had significant stenosis. In those with 0 CAC, 5.5% had atherosclerosis and 0.4% had significant stenosis. In participants with 0 CAC and intermediate 10-year risk of atherosclerotic cardiovascular disease according to the pooled cohort equation, 9.2% had CCTA-verified atherosclerosis. Prevalence estimates had excellent external validity and changed marginally when adjusted to the age-matched Swedish background population.Conclusions: Using CCTA in a large, random sample of the general population without established disease, we showed that silent coronary atherosclerosis is common in this population. High CAC scores convey a significant probability of substantial stenosis, and 0 CAC does not exclude atherosclerosis, particularly in those at higher baseline risk.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Persson, MargarethaDepartment of Clinical Sciences (M.P., G. Berglund, G.E., M. Magnusson), Lund University, Malmö, Sweden.;Departments of Internal Medicine (M.P.), Skåne University Hospital, Malmö, Sweden.
(författare)
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Adiels, MartinSahlgrenska Academy, and School of Public Health and Community Medicine, Institute of Medicine (M.A., C.B.), University of Gothenburg, Sweden.
(författare)
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Björnson, EliasDepartment of Molecular and Clinical Medicine (G. Bergström, E.B., O.A., B.F., O.H., A.R.), University of Gothenburg, Sweden.
(författare)
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Bonander, CarlSahlgrenska Academy, and School of Public Health and Community Medicine, Institute of Medicine (M.A., C.B.), University of Gothenburg, Sweden.
(författare)
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Ahlström, HåkanSection of Radiology, Department of Surgical Sciences (H.A., O.D.), Uppsala University, Sweden.
(författare)
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Alfredsson, JoakimDepartments of Cardiology (J.A., E.S.), Linköping University, Sweden.;Health, Medicine and Caring Sciences (J.A., E.S., J.E.E., F.H.N., C.J.Ö., A.P.), Linköping University, Sweden.
(författare)
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Angerås, OskarDepartment of Molecular and Clinical Medicine (G. Bergström, E.B., O.A., B.F., O.H., A.R.), University of Gothenburg, Sweden.;Cardiology (O.A.), Region Västra Götaland, Gothenburg, Sweden.
(författare)
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Berglund, GöranDepartment of Clinical Sciences (M.P., G. Berglund, G.E., M. Magnusson), Lund University, Malmö, Sweden.
(författare)
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Blomberg, AndersDepartment of Public Health and Clinical Medicine, Medicine and Heart Centre (A.B., J.L., A. Sandström, A. Själander, S.S.), Umeå University, Sweden.
(författare)
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Brandberg, JohnDepartment of Radiology, Institute of Clinical Sciences (J.B., E.F., A.F.), University of Gothenburg, Sweden.;Radiology (J.B., E.F., A.F.), Region Västra Götaland, Gothenburg, Sweden.
(författare)
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Börjesson, MatsInstitute of Medicine (M.B.), University of Gothenburg, Sweden.;Center for Health and Performance (M.B.), University of Gothenburg, Sweden.;Sahlgrenska University Hospital (M.B., B.F., A.R., K.T.), Region Västra Götaland, Gothenburg, Sweden.
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Cederlund, KerstinDepartment of Clinical Science, Intervention and Technology (K.C.), Karolinska Institutet, Stockholm, Sweden.
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de Faire, UlfUnit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine (U.d.F.), Karolinska Institutet, Stockholm, Sweden.
(författare)
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Duvernoy, OlovSection of Radiology, Department of Surgical Sciences (H.A., O.D.), Uppsala University, Sweden.
(författare)
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Ekblom, Örjan,1971-Gymnastik- och idrottshögskolan,Institutionen för fysisk aktivitet och hälsa(Swepub:gih)orjane
(författare)
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Engström, GunnarDepartment of Clinical Sciences (M.P., G. Berglund, G.E., M. Magnusson), Lund University, Malmö, Sweden.
(författare)
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Engvall, Jan E.Health, Medicine and Caring Sciences (J.A., E.S., J.E.E., F.H.N., C.J.Ö., A.P.), Linköping University, Sweden.;Clinical Physiology (J.E.E.), Linköping University, Sweden.;CMIV, Centre of Medical Image Science and Visualization (J.E.E., A.P., C.J.Ö.), Linköping University, Sweden.
(författare)
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Fagman, ErikaDepartment of Radiology, Institute of Clinical Sciences (J.B., E.F., A.F.), University of Gothenburg, Sweden.;Radiology (J.B., E.F., A.F.), Region Västra Götaland, Gothenburg, Sweden.
(författare)
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Eriksson, MatsDepartment of Endocrinology, Metabolism & Diabetes and Clinical Research Center, Karolinska University Hospital Huddinge, Stockholm, Sweden (M.E.).
(författare)
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Erlinge, DavidDepartment of Clinical Sciences Lund, Cardiology, Lund University and Skåne University Hospital, Lund, Sweden (D.E., M.A.M.).
(författare)
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Fagerberg, BjörnDepartment of Molecular and Clinical Medicine (G. Bergström, E.B., O.A., B.F., O.H., A.R.), University of Gothenburg, Sweden.;Sahlgrenska University Hospital (M.B., B.F., A.R., K.T.), Region Västra Götaland, Gothenburg, Sweden.
(författare)
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Flinck, AgnetaDepartment of Radiology, Institute of Clinical Sciences (J.B., E.F., A.F.), University of Gothenburg, Sweden.;Radiology (J.B., E.F., A.F.), Region Västra Götaland, Gothenburg, Sweden.
(författare)
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Gonçalves, IsabelDepartment of Clinical Sciences Malmö (I.G.), Lund University and Skåne University Hospital, Lund, Sweden.
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Hagström, EmilCardiology (E.H.), Uppsala University, Sweden.;Department of Medical Sciences, and Uppsala Clinical Research Center (E.H.), Uppsala University, Sweden.
(författare)
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Hjelmgren, OlaDepartment of Molecular and Clinical Medicine (G. Bergström, E.B., O.A., B.F., O.H., A.R.), University of Gothenburg, Sweden.;Departments of Clinical Physiology (G. Bergström, O.H.), Region Västra Götaland, Gothenburg, Sweden.
(författare)
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Lind, LarsClinical Epidemiology (L.L., J.S.), Uppsala University, Sweden.
(författare)
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Lindberg, EvaRespiratory, Allergy and Sleep Research (E.L.), Uppsala University, Sweden.
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Lindqvist, PerDepartment of Surgical and Perioperative Sciences (P.L.), Umeå University, Sweden.
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Ljungberg, JohanDepartment of Public Health and Clinical Medicine, Medicine and Heart Centre (A.B., J.L., A. Sandström, A. Själander, S.S.), Umeå University, Sweden.
(författare)
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Magnusson, MartinDepartment of Clinical Sciences (M.P., G. Berglund, G.E., M. Magnusson), Lund University, Malmö, Sweden.;Cardiology (M. Magnusson), Skåne University Hospital, Malmö, Sweden.;Wallenberg Center for Molecular Medicine, Lund University, Sweden (M. Magnusson).;North-West University, Hypertension in Africa Research Team (HART), Potchefstroom, South Africa (M. Magnusson).
(författare)
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Mannila, MariaHeart and Vascular Theme, Department of Cardiology, and Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden (M. Mannila).
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Markstad, HannaExperimental Cardiovascular Research, Clinical Research Center, Clinical Sciences Malmö (H.M.), Lund University, Malmö, Sweden.;Center for Medical Imaging and Physiology (H.M.), Lund University and Skåne University Hospital, Lund, Sweden.
(författare)
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Mohammad, Moman A.Department of Clinical Sciences Lund, Cardiology, Lund University and Skåne University Hospital, Lund, Sweden (D.E., M.A.M.).
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Nystrom, Fredrik H.Health, Medicine and Caring Sciences (J.A., E.S., J.E.E., F.H.N., C.J.Ö., A.P.), Linköping University, Sweden.
(författare)
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Ostenfeld, EllenDepartment of Clinical Sciences Lund, Clinical Physiology (E.O.), Lund University and Skåne University Hospital, Lund, Sweden.
(författare)
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Persson, AndersHealth, Medicine and Caring Sciences (J.A., E.S., J.E.E., F.H.N., C.J.Ö., A.P.), Linköping University, Sweden.;Radiology (A.P.), Linköping University, Sweden.;CMIV, Centre of Medical Image Science and Visualization (J.E.E., A.P., C.J.Ö.), Linköping University, Sweden.
(författare)
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Rosengren, AnnikaDepartment of Molecular and Clinical Medicine (G. Bergström, E.B., O.A., B.F., O.H., A.R.), University of Gothenburg, Sweden.;Sahlgrenska University Hospital (M.B., B.F., A.R., K.T.), Region Västra Götaland, Gothenburg, Sweden.
(författare)
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Sandström, AnetteDepartment of Public Health and Clinical Medicine, Medicine and Heart Centre (A.B., J.L., A. Sandström, A. Själander, S.S.), Umeå University, Sweden.
(författare)
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Själander, AndersDepartment of Public Health and Clinical Medicine, Medicine and Heart Centre (A.B., J.L., A. Sandström, A. Själander, S.S.), Umeå University, Sweden.
(författare)
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Sköld, Magnus C.Respiratory Medicine Unit, Department of Medicine Solna and Center for Molecular Medicine (M.C.S.), Karolinska Institutet, Stockholm, Sweden.;Department of Respiratory Medicine and Allergy, Karolinska University Hospital Solna, Stockholm, Sweden (M.C.S.).
(författare)
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Sundström, JohanClinical Epidemiology (L.L., J.S.), Uppsala University, Sweden.;The George Institute for Global Health, University of New South Wales, Sydney, Australia (J.S.).
(författare)
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Swahn, EvaDepartments of Cardiology (J.A., E.S.), Linköping University, Sweden.;Health, Medicine and Caring Sciences (J.A., E.S., J.E.E., F.H.N., C.J.Ö., A.P.), Linköping University, Sweden.
(författare)
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Söderberg, StefanDepartment of Public Health and Clinical Medicine, Medicine and Heart Centre (A.B., J.L., A. Sandström, A. Själander, S.S.), Umeå University, Sweden.
(författare)
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Torén, KjellOccupational and Environmental Medicine/School of Public Health and Community Medicine (K.T.), University of Gothenburg, Sweden.;Sahlgrenska University Hospital (M.B., B.F., A.R., K.T.), Region Västra Götaland, Gothenburg, Sweden.
(författare)
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Östgren, Carl JohanHealth, Medicine and Caring Sciences (J.A., E.S., J.E.E., F.H.N., C.J.Ö., A.P.), Linköping University, Sweden.;CMIV, Centre of Medical Image Science and Visualization (J.E.E., A.P., C.J.Ö.), Linköping University, Sweden.
(författare)
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Jernberg, TomasDepartment of Clinical Sciences, Danderyd University Hospital (T.J.), Karolinska Institutet, Stockholm, Sweden.
(författare)
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Department of Molecular and Clinical Medicine (G. Bergström, E.B., O.A., B.F., O.H., A.R.), University of Gothenburg, Sweden.;Departments of Clinical Physiology (G. Bergström, O.H.), Region Västra Götaland, Gothenburg, Sweden.Department of Clinical Sciences (M.P., G. Berglund, G.E., M. Magnusson), Lund University, Malmö, Sweden.;Departments of Internal Medicine (M.P.), Skåne University Hospital, Malmö, Sweden.
(creator_code:org_t)
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Ingår i:Circulation: Wolters Kluwer144:12, s. 916-9290009-73221524-4539
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Bergström, Göran
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Persson, Margare ...
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Adiels, Martin
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Björnson, Elias
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Bonander, Carl
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Ahlström, Håkan
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visa fler...
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Alfredsson, Joak ...
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Angerås, Oskar
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Berglund, Göran
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Blomberg, Anders
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Brandberg, John
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Börjesson, Mats
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Cederlund, Kerst ...
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de Faire, Ulf
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Duvernoy, Olov
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Ekblom, Örjan, 1 ...
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Engström, Gunnar
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Engvall, Jan E.
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Fagman, Erika
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Eriksson, Mats
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Erlinge, David
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Fagerberg, Björn
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Flinck, Agneta
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Gonçalves, Isabe ...
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Hagström, Emil
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Hjelmgren, Ola
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Lind, Lars
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Lindberg, Eva
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Lindqvist, Per
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Ljungberg, Johan
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Magnusson, Marti ...
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Mannila, Maria
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Markstad, Hanna
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Mohammad, Moman ...
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Nystrom, Fredrik ...
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Ostenfeld, Ellen
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Persson, Anders
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Rosengren, Annik ...
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Sandström, Anett ...
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Själander, Ander ...
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Sköld, Magnus C.
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Sundström, Johan
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Swahn, Eva
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Söderberg, Stefa ...
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Torén, Kjell
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Östgren, Carl Jo ...
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Jernberg, Tomas
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