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Age-related differe...
Age-related differences in white matter microstructure measured by advanced diffusion MRI in healthy older adults at risk for Alzheimer’s disease
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- Motovylyak, Alice (author)
- University of Wisconsin School of Medicine and Public Health, Madison, USA
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- Vogt, Nicholas M. (author)
- University of Wisconsin School of Medicine and Public Health, Madison, USA
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- Adluru, Nagesh (author)
- University of Wisconsin, Madison, USA
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- Ma, Yue (author)
- University of Wisconsin School of Medicine and Public Health, Madison, USA
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- Wang, Rui (author)
- Karolinska Institutet,Gymnastik- och idrottshögskolan,Institutionen för fysisk aktivitet och hälsa,University of Wisconsin School of Medicine and Public Health, Madison, USA,Fysisk aktivitet och hjärnhälsa
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- Oh, Jennifer M. (author)
- University of Wisconsin School of Medicine and Public Health, Madison, USA
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- Kecskemeti, Steven R. (author)
- University of Wisconsin, Madison, USA
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- Alexander, Andrew L. (author)
- University of Wisconsin, Madison, USA
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- Dean, Douglas C. (author)
- University of Wisconsin, Madison, USA
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- Gallagher, Catherine L. (author)
- University of Wisconsin School of Medicine and Public Health, Madison, USA
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- Sager, Mark A. (author)
- University of Wisconsin School of Medicine and Public Health, Madison, USA
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- Hermann, Bruce P. (author)
- University of Wisconsin School of Medicine and Public Health, Madison, USA
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- Rowley, Howard A. (author)
- University of Wisconsin School of Medicine and Public Health, Madison, USA
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- Johnson, Sterling C. (author)
- University of Wisconsin School of Medicine and Public Health, Madison, USA
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- Asthana, Sanjay (author)
- University of Wisconsin School of Medicine and Public Health, Madison, USA
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- Bendlin, Barbara B. (author)
- University of Wisconsin School of Medicine and Public Health, Madison, USA
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- Okonkwo, Ozioma C. (author)
- University of Wisconsin School of Medicine and Public Health, Madison, USA
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(creator_code:org_t)
- Elsevier, 2022
- 2022
- English.
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In: Aging Brain. - : Elsevier. - 2589-9589. ; 2
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Abstract
Subject headings
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- Neurite orientation dispersion and density imaging (NODDI) is an advanced diffusion imaging technique, which can detect more distinct microstructural features compared to conventional Diffusion Tensor Imaging (DTI). NODDI allows the signal to be divided into multiple water compartments and derive measures for orientation dispersion index (ODI), neurite density index (NDI) and volume fraction of isotropic diffusion compartment (FISO). This study aimed to investigate which diffusion metric—fractional anisotropy (FA), mean diffusivity (MD), NDI, ODI, or FISO—is most influenced by aging and reflects cognitive function in a population of healthy older adults at risk for Alzheimer’s disease (AD). Age was significantly associated with all but one diffusion parameters and regions of interest. NDI and MD in the cingulate region adjacent to the cingulate cortex showed a significant association with a composite measure of Executive Function and was proven to partially mediate the relationship between aging and Executive Function decline. These results suggest that both DTI and NODDI parameters are sensitive to age-related differences in white matter regions vulnerable to aging, particularly among older adults at risk for AD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Aging
- Alzheimer’s disease (AD)
- Diffusion tensor imaging (DTI)
- Magnetic resonance imaging (MRI)
- Neurite orientation dispersion and density imaging (NODDI)
- White matter
- E-PABS
- EPABS
- hjärnhälsa
- brain health
- Medicin/Teknik
- Medicine/Technology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Motovylyak, Alic ...
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Vogt, Nicholas M ...
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Adluru, Nagesh
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Ma, Yue
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Wang, Rui
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Oh, Jennifer M.
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show more...
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Kecskemeti, Stev ...
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Alexander, Andre ...
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Dean, Douglas C.
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Gallagher, Cathe ...
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Sager, Mark A.
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Hermann, Bruce P ...
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Rowley, Howard A ...
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Johnson, Sterlin ...
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Asthana, Sanjay
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Bendlin, Barbara ...
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Okonkwo, Ozioma ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Aging Brain
- By the university
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The Swedish School of Sport and Health Sciences
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Karolinska Institutet