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Reduced glucose tol...
Reduced glucose tolerance and insulin sensitivity after prolonged exercise in endurance athletes.
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- Flockhart, Mikael (author)
- Gymnastik- och idrottshögskolan,Institutionen för fysiologi, nutrition och biomekanik
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- Tischer, Dominik (author)
- Gymnastik- och idrottshögskolan,Institutionen för fysiologi, nutrition och biomekanik
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- Nilsson, Lina C. (author)
- Gymnastik- och idrottshögskolan,Institutionen för fysiologi, nutrition och biomekanik
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- Blackwood, Sarah J (author)
- Gymnastik- och idrottshögskolan,Institutionen för fysiologi, nutrition och biomekanik
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- Ekblom, Björn, 1938- (author)
- Gymnastik- och idrottshögskolan,Institutionen för fysiologi, nutrition och biomekanik
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- Katz, Abram (author)
- Gymnastik- och idrottshögskolan,Institutionen för fysiologi, nutrition och biomekanik
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- Apro, William, 1980- (author)
- Gymnastik- och idrottshögskolan,Institutionen för fysiologi, nutrition och biomekanik,Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
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- Larsen, Filip J, 1977- (author)
- Gymnastik- och idrottshögskolan,Institutionen för fysiologi, nutrition och biomekanik
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(creator_code:org_t)
- John Wiley & Sons, 2023
- 2023
- English.
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In: Acta Physiologica. - : John Wiley & Sons. - 1748-1708 .- 1748-1716. ; 238:4
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Abstract
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- AIM: The purpose of this study was to 1. investigate if glucose tolerance is affected after one acute bout of different types of exercise; 2. assess if potential differences between two exercise paradigms are related to changes in mitochondrial function; and 3. determine if endurance athletes differ from nonendurance-trained controls in their metabolic responses to the exercise paradigms.METHODS: Nine endurance athletes (END) and eight healthy nonendurance-trained controls (CON) were studied. Oral glucose tolerance tests (OGTT) and mitochondrial function were assessed on three occasions: in the morning, 14 h after an overnight fast without prior exercise (RE), as well as after 3 h of prolonged continuous exercise at 65% of VO2 max (PE) or 5 × 4 min at ~95% of VO2 max (HIIT) on a cycle ergometer.RESULTS: Glucose tolerance was markedly reduced in END after PE compared with RE. END also exhibited elevated fasting serum FFA and ketones levels, reduced insulin sensitivity and glucose oxidation, and increased fat oxidation during the OGTT. CON showed insignificant changes in glucose tolerance and the aforementioned measurements compared with RE. HIIT did not alter glucose tolerance in either group. Neither PE nor HIIT affected mitochondrial function in either group. END also exhibited increased activity of 3-hydroxyacyl-CoA dehydrogenase activity in muscle extracts vs. CON.CONCLUSION: Prolonged exercise reduces glucose tolerance and increases insulin resistance in endurance athletes the following day. These findings are associated with an increased lipid load, a high capacity to oxidize lipids, and increased fat oxidation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Idrottsvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Sport and Fitness Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- endurance athletes
- endurance exercise
- glucose tolerance
- insulin sensitivity
- mitochondria
- reactive oxygen species
- Medicin/Teknik
- Medicine/Technology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Flockhart, Mikae ...
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Tischer, Dominik
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Nilsson, Lina C.
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Blackwood, Sarah ...
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Ekblom, Björn, 1 ...
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Katz, Abram
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Apro, William, 1 ...
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Larsen, Filip J, ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Sport and Fitnes ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Acta Physiologic ...
- By the university
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The Swedish School of Sport and Health Sciences
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Karolinska Institutet