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Association between...
Association between umbilical cord artery pCO₂ and the Apgar score; elevated levels of pCO₂ may be beneficial for neonatal vitality after moderate acidemia.
- Artikel/kapitelEngelska2013
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2013-03-29
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John Wiley & Sons Ltd.2013
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Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:hb-1732
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https://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-1732URI
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https://doi.org/10.1111/aogs.12090DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:126742424URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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OBJECTIVE: To determine the association between 5-min Apgar score and umbilical cord artery carbon dioxide tension (pCO₂). DESIGN: Observational study. SETTING: European hospital labor wards. POPULATION: Data from 36,432 newborns ≥36 gestational weeks were obtained from three sources: two trials of monitoring with fetal electrocardiogram (the Swedish randomized controlled trial and the European Union Fetal ECG trial) and Mölndal Hospital data. After validation of the acid-base values, 25,806 5-min Apgar scores were available for analysis. METHODS: Validation of the umbilical cord acid-base values was performed to obtain reliable data. 5-min Apgar score was regressed against cord artery pCO₂ in a polynomial multilevel model. MAIN OUTCOME MEASURES: Five-min Apgar score, umbilical cord pCO₂, pH, and base deficit. RESULTS: Overall, a higher cord artery pCO₂ was found to be associated with lower 5-min Apgar scores. However, among newborns with moderate acidemia, lower umbilical cord artery pCO₂ (≤median pCO₂ for the specific cord artery pH) was associated with lower 5-min Apgar scores, with a relative risk of 2.0 (95% confidence interval: 1.4-2.8) for 5-min Apgar scores 0-6. CONCLUSIONS: Metabolic acidosis affects the newborn's vitality more than respiratory acidosis. In addition, elevated levels of pCO₂ may be beneficial for fetuses with moderate acidemia, and thus cord artery pCO₂ is a factor that should be considered when assessing the compromised newborn.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Yli B, M
(författare)
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Rasmussen, S
(författare)
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Norèn, H
(författare)
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Amer-Wåhlin, IKarolinska Institutet
(författare)
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Rosén, KGHögskolan i Borås,Institutionen Ingenjörshögskolan(Swepub:hb)kgr
(författare)
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Stray-Pedersen, B
(författare)
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Saugstad, OD
(författare)
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Karolinska InstitutetInstitutionen Ingenjörshögskolan
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Acta Obstetricia et Gynecologica Scandinavica: John Wiley & Sons Ltd.92:6, s. 662-700001-63491600-0412
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