Search: id:"swepub:oai:DiVA.org:hb-1985" >
Mechanical chest co...
-
Rubertsson, StenUppsala universitet,Anestesiologi och intensivvård
(author)
Mechanical chest compressions and simultanous defibrillationvs conventional cardiopulmonary resuscitationin out-of hospital cardiac arrest:the LINC randomized trial
- Article/chapterEnglish2014
Publisher, publication year, extent ...
-
American Medical Association,2014
-
printrdacarrier
Numbers
-
LIBRIS-ID:oai:DiVA.org:hb-1985
-
https://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-1985URI
-
https://doi.org/10.1001/jama.2013.282538DOI
-
https://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-1663URI
-
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-216731URI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
IMPORTANCE: A strategy using mechanical chest compressions might improve the poor outcome in out-of-hospital cardiac arrest, but such a strategy has not been tested in large clinical trials. OBJECTIVE: To determine whether administering mechanical chest compressions with defibrillation during ongoing compressions (mechanical CPR), compared with manual cardiopulmonary resuscitation (manual CPR), according to guidelines, would improve 4-hour survival. DESIGN, SETTING, AND PARTICIPANTS: Multicenter randomized clinical trial of 2589 patients with out-of-hospital cardiac arrest conducted between January 2008 and February 2013 in 4 Swedish, 1 British, and 1 Dutch ambulance services and their referring hospitals. Duration of follow-up was 6 months. INTERVENTIONS: Patients were randomized to receive either mechanical chest compressions (LUCAS Chest Compression System, Physio-Control/Jolife AB) combined with defibrillation during ongoing compressions (n = 1300) or to manual CPR according to guidelines (n = 1289). MAIN OUTCOMES AND MEASURES: Four-hour survival, with secondary end points of survival up to 6 months with good neurological outcome using the Cerebral Performance Category (CPC) score. A CPC score of 1 or 2 was classified as a good outcome. RESULTS: Four-hour survival was achieved in 307 patients (23.6%) with mechanical CPR and 305 (23.7%) with manual CPR (risk difference, -0.05%; 95% CI, -3.3% to 3.2%; P > .99). Survival with a CPC score of 1 or 2 occurred in 98 (7.5%) vs 82 (6.4%) (risk difference, 1.18%; 95% CI, -0.78% to 3.1%) at intensive care unit discharge, in 108 (8.3%) vs 100 (7.8%) (risk difference, 0.55%; 95% CI, -1.5% to 2.6%) at hospital discharge, in 105 (8.1%) vs 94 (7.3%) (risk difference, 0.78%; 95% CI, -1.3% to 2.8%) at 1 month, and in 110 (8.5%) vs 98 (7.6%) (risk difference, 0.86%; 95% CI, -1.2% to 3.0%) at 6 months with mechanical CPR and manual CPR, respectively. Among patients surviving at 6 months, 99% in the mechanical CPR group and 94% in the manual CPR group had CPC scores of 1 or 2. CONCLUSIONS AND RELEVANCE: Among adults with out-of-hospital cardiac arrest, there was no significant difference in 4-hour survival between patients treated with the mechanical CPR algorithm or those treated with guideline-adherent manual CPR. The vast majority of survivors in both groups had good neurological outcomes by 6 months. In clinical practice, mechanical CPR using the presented algorithm did not result in improved effectiveness compared with manual CPR. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00609778.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Lindgren, ErikUppsala universitet,Anestesiologi och intensivvård(Swepub:uu)erili635
(author)
-
Smekal, DavidUppsala universitet,Anestesiologi och intensivvård(Swepub:uu)davsm531
(author)
-
Östlund, OllieUppsala universitet,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)oos27600
(author)
-
Silverstolpe, Johan
(author)
-
Lichtveld, Robert A
(author)
-
Boomars, Rene
(author)
-
Ahlstedt, Björn
(author)
-
Skoog, Gunnar
(author)
-
Kastberg, Robert
(author)
-
Halliwell, David
(author)
-
Box, Martyn
(author)
-
Herlitz, JohanHögskolan i Borås,Institutionen för Vårdvetenskap,Prehospital akutsjukvård(Swepub:hb)jhz
(author)
-
Karlsten, RolfUppsala universitet,Anestesiologi och intensivvård(Swepub:uu)rolfkarl
(author)
-
Smekal, E
(author)
-
Skoog, B
(author)
-
Uppsala universitetAnestesiologi och intensivvård
(creator_code:org_t)
Related titles
-
In:Journal of the American Medical Association (JAMA): American Medical Association311:1, s. 53-610098-74841538-3598
Internet link
Find in a library
To the university's database
- By the author/editor
-
Rubertsson, Sten
-
Lindgren, Erik
-
Smekal, David
-
Östlund, Ollie
-
Silverstolpe, Jo ...
-
Lichtveld, Rober ...
-
show more...
-
Boomars, Rene
-
Ahlstedt, Björn
-
Skoog, Gunnar
-
Kastberg, Robert
-
Halliwell, David
-
Box, Martyn
-
Herlitz, Johan
-
Karlsten, Rolf
-
Smekal, E
-
Skoog, B
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Health Sciences
-
and Nursing
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cardiac and Card ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Dermatology and ...
- Articles in the publication
-
Journal of the A ...
- By the university
-
University of Borås
-
Uppsala University