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Effect of Oxygen Th...
Effect of Oxygen Therapy on Cardiovascular Outcomes in Relation to Baseline Oxygen Saturation.
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- James, Stefan, 1964- (author)
- Uppsala University,Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi,UCR,Uppsala Univ, Sweden; Uppsala Univ, Sweden
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- Erlinge, David (author)
- Lund University,Lunds universitet,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Molecular Cardiology,Lund University Research Groups,Lund Univ, Sweden
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- Herlitz, Johan, 1949- (author)
- University of Borås,Högskolan i Borås,Akademin för vård, arbetsliv och välfärd,Department of Health Sciences, University of Borås, Borås, Sweden,Univ Boras, Sweden
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- Alfredsson, Joakim, 1962- (author)
- Linköpings universitet,Linköping University,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US
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- Koul, Sasha (author)
- Lund University,Lunds universitet,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Molecular Cardiology,Lund University Research Groups,Lund Univ, Sweden
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- Fröbert, Ole, 1964- (author)
- Örebro University,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Cardiology, Faculty of Medicine and Health, Örebro University,Orebro Univ, Sweden
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- Kellerth, Thomas (author)
- Örebro University,Orebro Univ, Sweden
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- Ravn-Fischer, Annica, 1974 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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- Alström, Patrik (author)
- Karolinska Institute,Karolinska Inst, Sweden
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- Östlund, Ollie (author)
- Uppsala University,Uppsala Univ, Sweden
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- Jernberg, Tomas (author)
- Karolinska Institutet,Karolinska Institute,Danderyd Hospital,Karolinska Inst, Sweden
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- Lindahl, Bertil, 1957- (author)
- Uppsala University,Uppsala universitet,Kardiologi,UCR,Uppsala Univ, Sweden; Uppsala Univ, Sweden
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- Hofmann, Robin (author)
- Karolinska Institutet,Karolinska Institute,Karolinska Inst, Sweden
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- Östlund, Olof Petter (author)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)
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- Ekelund, Ulf (creator_code:cre_t)
- Lund University,Lunds universitet
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(creator_code:org_t)
- 2019
- 2019
- English.
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In: JACC. - : Elsevier BV. - 1936-8798 .- 1876-7605.
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Abstract
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- OBJECTIVES: The aim of this study was to determine the effect of supplemental oxygen in patients with myocardial infarction (MI) on the composite of all-cause death, rehospitalization with MI, or heart failure related to baseline oxygen saturation. A secondary objective was to investigate outcomes in patients developing hypoxemia.BACKGROUND: In the DETO2X-AMI (Determination of the Role of Oxygen in Suspected Acute Myocardial Infarction) trial, 6,629 normoxemic patients with suspected MI were randomized to oxygen at 6 l/min for 6 to 12 hours or ambient air.METHODS: The study population of 5,010 patients with confirmed MI was divided by baseline oxygen saturation into a low-normal (90% to 94%) and a high-normal (95% to 100%) cohort. Outcomes are reported within 1 year. To increase power, all follow-up time (between 1 and 4 years) was included post hoc, and interaction analyses were performed with oxygen saturation as a continuous covariate.RESULTS: The composite endpoint of all-cause death, rehospitalization with MI, or heart failure occurred significantly more often in patients in the low-normal cohort (17.3%) compared with those in the high-normal cohort (9.5%) (p < 0.001), and most often in patients developing hypoxemia (23.6%). Oxygen therapy compared with ambient air was not associated with improved outcomes regardless of baseline oxygen saturation (interaction p values: composite endpoint, p = 0.79; all-cause death, p = 0.33; rehospitalization with MI, p = 0.86; hospitalization for heart failure, p = 0.35).CONCLUSIONS: Irrespective of oxygen saturation at baseline, we found no clinically relevant beneficial effect of routine oxygen therapy in normoxemic patients with MI regarding cardiovascular outcomes. Low-normal baseline oxygen saturation or development of hypoxemia was identified as an independent marker of poor prognosis. (An Efficacy and Outcome Study of Supplemental Oxygen Treatment in Patients With Suspected Myocardial Infarction; NCT01787110).
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- cardiovascular outcomes
- myocardial infarction
- oxygen therapy
- randomized clinical trial
- reactive oxygen species
- Människan i vården
- The Human Perspective in Care
- cardiovascular outcomes
- myocardial infarction
- oxygen therapy
- randomized clinical trial
- reactive oxygen species
Publication and Content Type
- ref (subject category)
- art (subject category)
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JACC
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- By the author/editor
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James, Stefan, 1 ...
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Erlinge, David
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Herlitz, Johan, ...
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Alfredsson, Joak ...
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Koul, Sasha
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Fröbert, Ole, 19 ...
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Kellerth, Thomas
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Ravn-Fischer, An ...
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Alström, Patrik
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Östlund, Ollie
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Jernberg, Tomas
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Lindahl, Bertil, ...
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Hofmann, Robin
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Östlund, Olof Pe ...
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Ekelund, Ulf
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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JACC
- By the university
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University of Borås
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Örebro University
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Uppsala University
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Lund University
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Linköping University
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Karolinska Institutet
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University of Gothenburg
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