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Routine Oxygen Ther...
Routine Oxygen Therapy Does Not Improve Health-Related Quality of Life in Patients With Acute Myocardial Infarction—Insights From the Randomized DETO2X-AMI Trial
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- Hofmann, R. (författare)
- Karolinska Institutet,Karolinska Institute,1Division of Cardiology, Department of Clinical Science and Education, Karolinska Institutet, Södersjukhuset, Stockholm, Sweden,Karolinska Inst, Sodersjukhuset, Dept Clin Sci & Educ, Div Cardiol, Stockholm, Sweden.
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- Abebe, Tamrat Befekadu (författare)
- Uppsala universitet,Uppsala University,2Department of Medical Sciences, Uppsala University, Uppsala, Sweden,Kardiologi,Uppsala Univ, Sweden
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- Herlitz, Johan, 1949- (författare)
- University of Borås,Högskolan i Borås,Akademin för vård, arbetsliv och välfärd,Univ Borås, Dept Hlth Sci, Borås, Sweden.
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- James, Stefan, 1964- (författare)
- Uppsala universitet,Uppsala University,Uppsala University Hospital,2Department of Medical Sciences, Uppsala University, Uppsala, Sweden,Kardiologi,Uppsala kliniska forskningscentrum (UCR),Klinisk fysiologi,Uppsala Univ, Sweden; Uppsala Univ, Sweden
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- Erlinge, David (författare)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Molecular Cardiology,Lund University Research Groups,5Department of Clinical Sciences, Cardiology, Lund University, Lund, Sweden,Lund Univ, Dept Clin Sci, Cardiol, Lund, Sweden.
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- Yndigegn, Troels (författare)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,5Department of Clinical Sciences, Cardiology, Lund University, Lund, Sweden,Lund Univ, Dept Clin Sci, Cardiol, Lund, Sweden.
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- Alfredsson, Joakim, 1962- (författare)
- Linköpings universitet,Linköping University,Linköping University Hospital,6Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden,Linköping Univ, Dept Hlth Med & Caring Sci, Linköping, Sweden.;Linköping Univ Hosp, Dept Cardiol, Linköping, Sweden.,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US
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- Kellerth, T. (författare)
- Örebro University,8Department of Cardiology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden,Örebro Univ, Fac Med & Hlth, Dept Cardiol, Örebro, Sweden.
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- Ravn-Fischer, Annica, 1974 (författare)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,9Department of Molecular and Clinical Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden,Sahlgrens Univ Hosp, Dept Mol & Clin Med, Gothenburg, Sweden.;Univ Gothenburg, Dept Cardiol, Gothenburg, Sweden.,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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- Völz, Sebastian, 1980 (författare)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,9Department of Molecular and Clinical Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden,Sahlgrens Univ Hosp, Dept Mol & Clin Med, Gothenburg, Sweden.;Univ Gothenburg, Dept Cardiol, Gothenburg, Sweden.,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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- Lauermann, Jörg (författare)
- Linköpings universitet,Linköping University,Ryhov County Hospital, Jönköping,11Department of Cardiology, Ryhov Hospital, Jönköping, Sweden,Ryhov Hosp, Dept Cardiol, Jönköping, Sweden.;Linköping Univ, Dept Hlth Med & Caring, Linköping, Sweden.,Institutionen för hälsa, medicin och vård,Medicinska fakulteten
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- Jernberg, T. (författare)
- Karolinska Institutet
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- Lindahl, Bertil, 1957- (författare)
- Uppsala universitet,Uppsala University,Uppsala University Hospital,2Department of Medical Sciences, Uppsala University, Uppsala, Sweden,Kardiologi,Uppsala kliniska forskningscentrum (UCR),Klinisk fysiologi,Uppsala Univ, Sweden; Uppsala Univ, Sweden
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- Langenskiöld, Sophie, 1968- (författare)
- Uppsala universitet,Uppsala University,2Department of Medical Sciences, Uppsala University, Uppsala, Sweden,Kardiologi,Hälsoekonomi,Uppsala Univ, Sweden
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Herlitz, Hans, 1946 (författare)
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(creator_code:org_t)
- 2021-03-15
- 2021
- Engelska.
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Ingår i: Frontiers in Cardiovascular Medicine. - : Frontiers Media S.A.. - 2297-055X. ; 8
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Background: After decades of ubiquitous oxygen therapy in all patients with acute myocardial infarction (MI), recent guidelines are more restrictive based on lack of efficacy in contemporary trials evaluating hard clinical outcomes in patients without hypoxemia at baseline. However, no evidence regarding treatment effects on health-related quality of life (HRQoL) exists. In this study, we investigated the impact of routine oxygen supplementation on HRQoL 6–8 weeks after hospitalization with acute MI. Secondary objectives included analyses of MI subtypes, further adjustment for infarct size, and oxygen saturation at baseline and 1-year follow-up.Methods: In the DETermination of the role of Oxygen in suspected Acute Myocardial Infarction (DETO2X-AMI) trial, 6,629 normoxemic patients with suspected MI were randomized to oxygen at 6 L/min for 6–12 h or ambient air. In this prespecified analysis, patients younger than 75 years of age with confirmed MI who had available HRQoL data by European Quality of Life Five Dimensions questionnaire (EQ-5D) in the national registry were included. Primary endpoint was the EQ-5D index assessed by multivariate linear regression at 6–10 weeks after MI occurrence.Results: A total of 3,086 patients (median age 64, 22% female) were eligible, 1,518 allocated to oxygen and 1,568 to ambient air. We found no statistically significant effect of oxygen therapy on EQ-5D index (−0.01; 95% CI: −0.03–0.01; p = 0.23) or EQ-VAS score (−0.57; 95% CI: −1.88–0.75; p = 0.40) compared to ambient air after 6–10 weeks. Furthermore, no significant difference was observed between the treatment groups in EQ-5D dimensions. Results remained consistent across MI subtypes and at 1-year follow-up, including further adjustment for infarct size or oxygen saturation at baseline.Conclusions: Routine oxygen therapy provided to normoxemic patients with acute MI did not improve HRQoL up to 1 year after MI occurrence. Clinical Trial Registration: ClinicalTrials.gov number, NCT01787110.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- health-realted quality of life
- myocardial infarction
- oxygen therapy
- patient reported clinical outcomes
- Registry-based randomized clinical trial
- secondary prevention
- acetylsalicylic acid
- beta adrenergic receptor blocking agent
- calcium channel blocking agent
- diuretic agent
- statin (protein)
- acute heart infarction
- adult
- ambient air
- Article
- controlled study
- female
- human
- major clinical study
- male
- middle aged
- non ST segment elevation myocardial infarction
- open study
- quality of life
- questionnaire
- randomized controlled trial
- smoking
- ST segment elevation myocardial infarction
- systolic blood pressure
- health-realted quality of life
- myocardial infarction
- oxygen therapy
- patient reported clinical outcomes
- Registry-based randomized clinical trial
- secondary prevention
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- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Hofmann, R.
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Abebe, Tamrat Be ...
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Herlitz, Johan, ...
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James, Stefan, 1 ...
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Erlinge, David
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Yndigegn, Troels
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visa fler...
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Alfredsson, Joak ...
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Kellerth, T.
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Ravn-Fischer, An ...
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Völz, Sebastian, ...
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Lauermann, Jörg
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Jernberg, T.
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Lindahl, Bertil, ...
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Langenskiöld, So ...
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Herlitz, Hans, 1 ...
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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Högskolan i Borås
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Lunds universitet
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Uppsala universitet
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Linköpings universitet
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Karolinska Institutet
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Göteborgs universitet