High-level co-production of 3-hydroxypropionic acid and 1,3-propanediol from glycerol: Metabolic engineering and process optimization

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Zhang, YufeiSchool of Food and Biological Engineering, Jiangsu University, 301 Xuefu Road, Zhenjiang 212013, Jiangsu, PR China (author)

High-level co-production of 3-hydroxypropionic acid and 1,3-propanediol from glycerol : Metabolic engineering and process optimization

Article/chapterEnglish2023

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Elsevier BV,2023
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LIBRIS-ID:oai:DiVA.org:hb-29322
https://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-29322URI
https://doi.org/10.1016/j.biortech.2022.128438DOI

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Language:English
Summary in:English

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

3-Hydroxypropionic acid (3-HP) and 1,3-propanediol (1,3-PDO) are value-added chemicals with versatile ap-plications in the chemical, pharmaceutical, and food industries. Nevertheless, sustainable production of 3-HP and 1,3-PDO is often limited by the lack of efficient strains and suitable fermentation configurations. Herein, attempts have been made to improve the co-production of both metabolites through metabolic engineering of Escherichia coli and process optimization. First, the 3-HP and 1,3-PDO co-biosynthetic pathways were recruited and opti-mized in E. coli, followed by coupling the pathways to the transhydrogenase-mediated cofactor regeneration systems that increased cofactor availability and product synthesis. Next, pathway rebalancing and block of by-product formation significantly improved 3-HP and 1,3-PDO net titer. Subsequently, glycerol flux toward 3 -HP and 1,3-PDO synthesis was maximized by removing metabolic repression and fine-tuning the glycerol oxidation pathway. Lastly, the combined fermentation process optimization and two-stage pH-controlled fed -batch fermentation co-produced 140.50 g/L 3-HP and 1,3-PDO, with 0.85 mol/mol net yield.

Subject headings and genre

TEKNIK OCH TEKNOLOGIER Industriell bioteknik Annan industriell bioteknik hsv//swe
ENGINEERING AND TECHNOLOGY Industrial Biotechnology Other Industrial Biotechnology hsv//eng
Glycerol valorization
3-Hydroxypropionic acid
13-Propanediol
Metabolic engineering
Co-production
Resource Recovery
Resursåtervinning
Resource Recovery
Resursåtervinning

Added entries (persons, corporate bodies, meetings, titles ...)

Yun, JunhuaSchool of Food and Biological Engineering, Jiangsu University, 301 Xuefu Road, Zhenjiang 212013, Jiangsu, PR China (author)
Zabed, Hossain M.School of Food and Biological Engineering, Jiangsu University, 301 Xuefu Road, Zhenjiang 212013, Jiangsu, PR China (author)
Dou, YuanSchool of Food and Biological Engineering, Jiangsu University, 301 Xuefu Road, Zhenjiang 212013, Jiangsu, PR China (author)
Zhang, GuoyanSchool of Food and Biological Engineering, Jiangsu University, 301 Xuefu Road, Zhenjiang 212013, Jiangsu, PR China (author)
Zhao, MeiSchool of Food and Biological Engineering, Jiangsu University, 301 Xuefu Road, Zhenjiang 212013, Jiangsu, PR China (author)
Taherzadeh, Mohammad J,1965-Högskolan i Borås,Akademin för textil, teknik och ekonomi,Swedish Centre for Resource Recovery(Swepub:hb)MJT (author)
Ragauskas, ArthurDepartment of Chemical and Biomolecular Engineering, The University of Tennessee, Knoxville, TN 37996, USA; Joint Institute for Biological Sciences, Biosciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37830, USA; Center for Renewable Carbon, Department of Forestry, Wildlife and Fisheries, The University of Tennessee, Knoxville, Tennessee 37996, USA (author)
Qi, XianghuiSchool of Food and Biological Engineering, Jiangsu University, 301 Xuefu Road, Zhenjiang 212013, Jiangsu, PR China (author)
School of Food and Biological Engineering, Jiangsu University, 301 Xuefu Road, Zhenjiang 212013, Jiangsu, PR ChinaAkademin för textil, teknik och ekonomi (creator_code:org_t)

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In:Bioresource Technology: Elsevier BV3690960-85241873-2976

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By the author/editor: Zhang, Yufei; Yun, Junhua; Zabed, Hossain M ...; Dou, Yuan; Zhang, Guoyan; Zhao, Mei; show more...; Taherzadeh, Moha ...; Ragauskas, Arthu ...; Qi, Xianghui; show less...

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ENGINEERING AND TECHNOLOGY: ENGINEERING AND ...; and Industrial Biote ...; and Other Industrial ...

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By the university: University of Borås

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