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Early treatment wit...
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Risenfors, M
(författare)
Early treatment with thrombolysis and betablockade in suspected acute myocardial infarction : results from the TEAHAT Study
- Artikel/kapitelEngelska1991
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Wiley-Blackwell Publishing Ltd.1991
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LIBRIS-ID:oai:DiVA.org:hb-7682
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https://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-7682URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Independent trials of early administration of beta-blockers and thrombolytic agents have shown beneficial effects on both short- and long-term prognoses in acute myocardial infarction (AMI). The effects of a combination of the two strategies have not been thoroughly documented. Three hundred and fifty-two patients, of less than 75 years of age, with chest pain indicative of AMI, and onset less than 2 h and 45 min before first examination, were randomized to treatment with rt-PA or placebo. All patients without contraindication were given intravenous metoprolol 15 mg acutely and then 200 mg orally daily. Treatment was started either at the prehospital stage or in hospital. Thirty-seven per cent of patients had contraindications to beta-blockade, the most frequent of which were heart rate less than 60 beats min-1 and hypotension. The remaining 63% were given intravenous beta-blockade. No side-effects of metoprolol, alone or in combination with rt-PA, were observed during the prehospital phase. Overall, toleration of the treatment was good. Reduction in enzymatically estimated infarct size by rt-PA was more pronounced in patients who were also treated with metoprolol (41%, P less than 0.001) than in those with contraindications to beta-blockade (15%, NS). Patients who were also treated with metoprolol also had a lower incidence of Q-wave infarctions, congestive heart failure and ventricular fibrillation than those who were not given intravenous beta-blockade. In conclusion, toleration of intravenous administration of rt-PA and metoprolol was good, and this was also the case in the prehospital phase.
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Herlitz, Johan[external](Swepub:hb)jhz
(författare)
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Bergh, C-H
(författare)
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Dellborg, M
(författare)
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Gottfridsson, C
(författare)
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Gustavsson, G
(författare)
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Lomsky, M
(författare)
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Swedberg, K
(författare)
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Hjalmarson, Å
(författare)
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[external]
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Internal Medicine: Wiley-Blackwell Publishing Ltd.734:suppl 1, s. 35-420954-68201365-2796
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