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Sökning: id:"swepub:oai:DiVA.org:hb-7682" > Early treatment wit...

  • Risenfors, M (författare)

Early treatment with thrombolysis and betablockade in suspected acute myocardial infarction : results from the TEAHAT Study

  • Artikel/kapitelEngelska1991

Förlag, utgivningsår, omfång ...

  • Wiley-Blackwell Publishing Ltd.1991
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:hb-7682
  • https://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-7682URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Independent trials of early administration of beta-blockers and thrombolytic agents have shown beneficial effects on both short- and long-term prognoses in acute myocardial infarction (AMI). The effects of a combination of the two strategies have not been thoroughly documented. Three hundred and fifty-two patients, of less than 75 years of age, with chest pain indicative of AMI, and onset less than 2 h and 45 min before first examination, were randomized to treatment with rt-PA or placebo. All patients without contraindication were given intravenous metoprolol 15 mg acutely and then 200 mg orally daily. Treatment was started either at the prehospital stage or in hospital. Thirty-seven per cent of patients had contraindications to beta-blockade, the most frequent of which were heart rate less than 60 beats min-1 and hypotension. The remaining 63% were given intravenous beta-blockade. No side-effects of metoprolol, alone or in combination with rt-PA, were observed during the prehospital phase. Overall, toleration of the treatment was good. Reduction in enzymatically estimated infarct size by rt-PA was more pronounced in patients who were also treated with metoprolol (41%, P less than 0.001) than in those with contraindications to beta-blockade (15%, NS). Patients who were also treated with metoprolol also had a lower incidence of Q-wave infarctions, congestive heart failure and ventricular fibrillation than those who were not given intravenous beta-blockade. In conclusion, toleration of intravenous administration of rt-PA and metoprolol was good, and this was also the case in the prehospital phase.

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Herlitz, Johan[external](Swepub:hb)jhz (författare)
  • Bergh, C-H (författare)
  • Dellborg, M (författare)
  • Gottfridsson, C (författare)
  • Gustavsson, G (författare)
  • Lomsky, M (författare)
  • Swedberg, K (författare)
  • Hjalmarson, Å (författare)
  • [external] (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of Internal Medicine: Wiley-Blackwell Publishing Ltd.734:suppl 1, s. 35-420954-68201365-2796

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