SwePub
Sök i LIBRIS databas

  Utökad sökning

L773:1522 9645
 

Sökning: L773:1522 9645 > (1990-1994) > Metoprolol-induced ...

  • Olsson, G (författare)

Metoprolol-induced reduction in post-infarction mortality : pooled results from five double-blind randomized trials

  • Artikel/kapitelEngelska1992

Förlag, utgivningsår, omfång ...

  • Oxford University Press,1992
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:hb-7701
  • https://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-7701URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Several postinfarction trials have evaluated the effect of secondary prophylaxis with different beta-blockers. Although so called meta-analysis of the results from all the trials have shown a beneficial effect of postinfarction beta-blockade, many of the individual studies have shown inconclusive results, mainly due to low statistical power. In order to obtain an evaluation of the merits of postinfarction therapy with metoprolol, data from the five available studies with metoprolol have been pooled into one database. In the total material 5474 patients (4353 men, 1121 women) have been studied during double-blind therapy with metoprolol 100 mg twice daily or matching placebo. The follow-up ranges from 3 months to 3 years. In total 4732 patient years of observation have been obtained. In total there were 223 deaths in the placebo-treated patients as compared to 188 deaths in the metoprolol-treated patients (P = 0.036), which corresponds to mortality rates of 97.0 and 78.3 per 1000 patient years, respectively. The mortality reduction was found both in men and women. As has been reported from individual postinfarction beta-blocker trials, the pooled results showed a marked reduction in sudden deaths (104 in the placebo group, 62 in the metoprolol group, P = 0.002). In a Cox regression model the influence of sex, age and smoking habits on the effect of metoprolol was evaluated. None of these factors influenced the metoprolol effect significantly. It is concluded that metoprolol therapy after acute myocardial infarction reduces the total number of deaths, and especially sudden cardiac deaths. The mortality reduction was independent of gender, age and smoking habits. Available data support a continuous beneficial effect.

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Wikstrand, J (författare)
  • Warnold, I (författare)
  • Manger Cats, V (författare)
  • McBoyle, D (författare)
  • Herlitz, JohanHögskolan i Borås,Institutionen för Vårdvetenskap,[external](Swepub:hb)jhz (författare)
  • Hjalmarson, Å (författare)
  • Sonnenblick, EH (författare)
  • Högskolan i BoråsInstitutionen för Vårdvetenskap (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:European Heart Journal: Oxford University Press13:1, s. 28-320195-668X1522-9645

Internetlänk

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy