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Protein Kinase R Is...
Protein Kinase R Is Constitutively Expressed in the Human Pancreas
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- Jonsson, Alexander (författare)
- Uppsala universitet,Klinisk immunologi
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- Yngve, Erik (författare)
- Uppsala universitet,Klinisk immunologi
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- Karlsson, Marie (författare)
- Uppsala universitet,Klinisk immunologi
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- Ingvast, Sofie (författare)
- Uppsala universitet,Klinisk immunologi
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- Skog, Oskar, Docent, PhD, 1981- (författare)
- Uppsala universitet,Klinisk immunologi
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- Korsgren, Olle (författare)
- Uppsala universitet,Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine,Klinisk immunologi,Univ Gothenburg, Inst Biomed, Gothenburg, Sweden
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(creator_code:org_t)
- 2018-09-28
- 2019
- Engelska.
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Ingår i: Journal of Histochemistry & Cytochemistry. - : SAGE Publications. - 0022-1554 .- 1551-5044. ; 67:2, s. 99-105
- Relaterad länk:
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https://journals.sag...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Viral infection of the insulin-producing cells in the pancreas has been proposed in the etiology of type 1 diabetes. Protein kinase R (PKR) is a cytoplasmic protein activated through phosphorylation in response to cellular stress and particularly viral infection. As PKR expression in pancreatic beta-cells has been interpreted as a viral footprint, this cross-sectional study aimed at characterizing the PKR expression in non-diabetic human pancreases. PKR expression was evaluated in pancreas tissue from 16 non-diabetic organ donors, using immunohistochemistry, qPCR, and western blot. Immunohistochemistry and western blot showed readily detectable PKR expression in the pancreatic parenchyma. The qPCR detected PKR mRNA in both endocrine and exocrine samples, with a slightly higher expression in the islets. In conclusion, PKR is constitutively expressed in both endocrine and exocrine parts of the pancreas and its expression should not be interpreted as a viral footprint in pancreatic beta cells.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- immunohistochemistry
- innate immunity
- pancreas
- PCR
- type 1 diabetes
- viral footprints
- viral
- interferon action
- pkr
- mechanism
- islets
- induction
- cells
- vp1
- Cell Biology
- immunohistochemistry
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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