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The specific glycos...
The specific glycosphingolipid composition of human ureteral epithelial cells.
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- Breimer, Michael, 1951 (författare)
- Gothenburg University,Göteborgs universitet,Medicinska institutionen,Department medicine
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- Hansson, Gunnar C., 1951 (författare)
- Gothenburg University,Göteborgs universitet,Medicinska institutionen,Department medicine
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Leffler, H (författare)
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(creator_code:org_t)
- 1985
- 1985
- Engelska.
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Ingår i: Journal of biochemistry. - 0021-924X. ; 98:5, s. 1169-80
- Relaterad länk:
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https://gup.ub.gu.se...
Abstract
Ämnesord
Stäng
- Total non-acid and acid glycolipid fractions were isolated from epithelial cell scrapings and the non-epithelial residue of a human upper ureter. The glycolipid fractions were structurally characterized as total mixtures by thin-layer chromatography, mass spectrometry, and proton NMR spectroscopy. Selected structural information was also obtained on binding of monoclonal antibodies and bacteria to the thin-layer chromatograms. The major epithelial cell glycolipids were Glc beta 1-1ceramide (75%), dihexosylceramide (10%) and NeuAcLacceramide (10%). In addition, 8 minor glycolipids belonging to the blood group P, Lewis and ABO systems were identified. The major glycolipids of the non-epithelial residues were mono- and dihexosylceramides together with globotriaosyl- and globotetraosylceramides. The epithelial mono- and diglycosylceramide compounds had an unusual ceramide composition with mainly C18 and C20 trihydroxy long chain bases in combination with C22-C24 hydroxy fatty acids in contrast to the non-epithelial glycolipids which contained mainly C18 dihydroxy long chain bases in combination with C16-C24 non-hydroxy fatty acids.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- Carbohydrates
- analysis
- Cholesterol
- analysis
- Chromatography
- Thin Layer
- Epithelial Cells
- Epithelium
- analysis
- Fatty Acids
- analysis
- Glycosphingolipids
- analysis
- Humans
- Kidney
- analysis
- Phospholipids
- analysis
- Ureter
- analysis
- cytology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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