Sökning: L773:0173 0835 OR L773:1522 2683 >
Transient isotachop...
Transient isotachophoresis for sensitivity enhancement in capillary electrophoresis-mass spectrometry for peptide analysis
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- Larsson, Marita (författare)
- DMPK and Bioanalytical Chemistry, AstraZeneca R&D Mölndal, Mölndal, Sweden
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- Lutz, Mareike, 1967- (författare)
- DMPK and Bioanalytical Chemistry, AstraZeneca R&D Mölndal, Mölndal, Sweden
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(creator_code:org_t)
- Weinheim : Wiley-VCH Verlagsgesellschaft, 2000
- 2000
- Engelska.
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Ingår i: Electrophoresis. - Weinheim : Wiley-VCH Verlagsgesellschaft. - 0173-0835 .- 1522-2683. ; 21:14, s. 2859-2865
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Transient isotachophoresic (ITP) focusing was used for the on-line analysis of peptides by capillary zone electrophoresis-mass spectrometry (CZE-MS), allowing injection volumes of up to 0.9 microL. A sheath liquid electrospray interface was used with a single quadrupole mass analyzer. First, the technique was applied to the qualitative analysis of a tryptic digest of cytochrome c, resulting in low-background, high-quality spectra. Second, the linear range was investigated by selected ion monitoring (SIM) for a peptidomimetic direct thrombin inhibitor melagatran (Mr 429.5) and two endogenous peptides, substance P (Mr 1348) and calcitonin gene-related peptide (alpha-CGRP; Mr 3806).
Ämnesord
- NATURVETENSKAP -- Kemi -- Analytisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Analytical Chemistry (hsv//eng)
Nyckelord
- Isotachophoresis
- Capillary electrophoresis
- Mass spectrometry
- Peptides
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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