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Intra-arterial AICA...
Intra-arterial AICA-riboside administration induces NO-dependent vasodilation in vivo in human skeletal muscle
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- Bosselaar, Marlies (författare)
- Department of General Internal Medicine, Radboud University, Nijmegen Medical Centre, Nijmegen, Netherlands & Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
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- Boon, Hanneke, 1981- (författare)
- Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, Netherlands
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- van Loon, Luc J. C. (författare)
- Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, Netherlands & Department of Human Movement Sciences, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, Netherlands
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- van den Broek, Petra H. H. (författare)
- Department of General Internal Medicine, Radboud University, Nijmegen Medical Centre, Nijmegen, Netherlands & Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
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- Smits, Paul (författare)
- Department of General Internal Medicine, Radboud University, Nijmegen Medical Centre, Nijmegen, Netherlands
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- Tack, Cees J. (författare)
- Department of General Internal Medicine, Radboud University, Nijmegen Medical Centre, Nijmegen, Netherlands
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(creator_code:org_t)
- Bethesda, MD : American Physiological Society, 2009
- 2009
- Engelska.
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Ingår i: American Journal of Physiology. Endocrinology and Metabolism. - Bethesda, MD : American Physiological Society. - 0193-1849 .- 1522-1555. ; 297:3, s. E759-E766
- Relaterad länk:
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https://doi.org/10.1...
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http://www.ncbi.nlm....
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http://ajpendo.physi...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- In animal models, administration of the adenosine analog AICA-riboside has shown beneficial effects on ischemia-reperfusion injury and glucose homeostasis. The vascular and/or metabolic effects of AICA-riboside administration in humans remain to be established. AICA-riboside was infused intra-arterially in four different dosages up to 8 mg·min-1·dl-1 in 24 healthy subjects. Forearm blood flow (FBF) and glucose uptake and plasma glucose, free fatty acid, and AICA-riboside concentrations were assessed. We also combined AICAriboside infusion (2 mg·min-1·dl -1) with the intra-arterial administration of the adenosine receptor antagonist caffeine (90 μg·min-1·dl-1; n = 6) and with the endothelial NO synthase inhibitor L-NMMA (0.4 mg·min-1·dl-1; n = 6). Additional in vitro experiments were performed to explain our in vivo effects of AICA-riboside in humans. AICA-riboside increased FBF dose dependently from 2.0 ± 0.2 to 13.2 ± 1.9 ml·min-1·dl-1 maximally (P < 0.05 for all dosages). The latter was not reduced by caffeine administration but was significantly attenuated by L-NMMA infusion. Despite high plasma AICA-riboside concentrations, forearm glucose uptake did not change. In vitro experiments showed rapid uptake of AICA-riboside by the equilibrative nucleoside transporter in erythrocytes and subsequent phosphorylation to AICA-ribotide. We conclude that AICA-riboside induces a potent vasodilator response in humans that is mediated by NO. Despite high local plasma concentrations, AICA-riboside does not increase skeletal muscle glucose uptake. Copyright © 2009 the American Physiological Society.
Nyckelord
- 5-Aminoimidazole-4-carboxamide
- Forearm blood flow
- Forearm glucose uptake
- Nitric oxide
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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