Sökning: WFRF:(Luiken J. J. F. P.) >
Skeletal muscle fat...
Skeletal muscle fatty acid transporter protein expression in type 2 diabetes patients compared with overweight, sedentary men and age-matched, endurance-trained cyclists
-
- Pelsers, M. M. A. L. (författare)
- Department of Movement Sciences, Maastricht University, Maastricht, Netherlands & Department of Movement Sciences, Maastricht University, Maastricht, Netherlands
-
- Tsintzas, K. (författare)
- Institute of Clinical Research, University of Nottingham Medical School, Nottingham, United Kingdom
-
- Boon, Hanneke, 1981- (författare)
- Department of Human Biology, Maastricht University, Maastricht, Netherlands
-
visa fler...
-
- Jewell, K. (författare)
- Institute of Clinical Research, University of Nottingham Medical School, Nottingham, United Kingdom
-
- Norton, L. (författare)
- Institute of Clinical Research, University of Nottingham Medical School, Nottingham, United Kingdom
-
- Luiken, J. J. F. P. (författare)
- Department of Molecular Genetics, Maastricht University, Maastricht, Netherlands
-
- Glatz, J. F. C. (författare)
- Department of Molecular Genetics, Maastricht University, Maastricht, Netherlands
-
- van Loon, L. J. (författare)
- Department of Movement Sciences, Maastricht University, Maastricht, the Netherlands & Department of Human Biology, Maastricht University, Maastricht, Netherlands
-
visa färre...
-
(creator_code:org_t)
- Chichester : Wiley-Blackwell, 2007
- 2007
- Engelska.
-
Ingår i: Acta Physiologica. - Chichester : Wiley-Blackwell. - 1748-1708 .- 1748-1716. ; 190:3, s. 209-219
- Relaterad länk:
-
https://cris.maastri...
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- AIM: Membrane fatty acid transporters can modulate the balance between fatty acid uptake and subsequent storage and/or oxidation in muscle tissue. As such, skeletal muscle fatty acid transporter protein expression could play an important role in the etiology of insulin resistance and/or type 2 diabetes.METHODS: In the present study, fatty acid translocase (FAT/CD36), plasma membrane-bound fatty acid-binding protein (FABPpm) and fatty acid transport protein 1 (FATP1) mRNA and protein expression were assessed in muscle tissue obtained from 10 sedentary, overweight type 2 diabetes patients (60 +/- 2 years), 10 sedentary, weight-matched normoglycemic controls (60 +/- 2 years) and 10 age-matched, endurance trained cyclists (57 +/- 1 years).RESULTS: Both FAT/CD36 and FATP1 mRNA and protein expression did not differ between groups. In contrast, FABPpm mRNA and protein expression were approx. 30-40% higher in the trained men compared with the diabetes patients (P < 0.01) and sedentary controls (P < 0.05).CONCLUSIONS: Skeletal muscle FAT/CD36, FABPpm and FATP1 mRNA and protein expression are not up- or downregulated in a sedentary and/or insulin resistant state. In contrast, FABPpm expression is upregulated in the endurance trained state and likely instrumental to allow greater fatty acid oxidation rates. © 2007 The Authors.
Nyckelord
- CD36
- exercise
- FABPpm
- FATP1
- GLUT4
- metabolism
- muscle
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas