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  • Rebelos, EleniUniversity of Turku, Turku, Finland (författare)

Insulin resistance is associated with enhanced brain glucose uptake during euglycemic hyperinsulinemia : A large-scale PET cohort

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • 2021-01-14
  • Arlington :American Diabetes Association Inc.2021
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:hh-45971
  • https://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-45971URI
  • https://doi.org/10.2337/dc20-1549DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • The study was conducted within the Center of Excellence in Cardiovascular and Metabolic Diseases, supported by the Academy of Finland, the University of Turku, Turku University Hospital, angstrom bo Akademi University, Finnish Diabetes Foundation, Sigrid Juselius Foundation, and Finnish Cultural Foundation.
  • OBJECTIVE Whereas insulin resistance is expressed as reduced glucose uptake in peripheral tissues, the relationship between insulin resistance and brain glucose metabolism remains controversial. Our aim was to examine the association of insulin resistance and brain glucose uptake (BGU) during a euglycemic hyperinsulinemic clamp in a large sample of study participants across a wide range of age and insulin sensitivity. RESEARCH DESIGN AND METHODS [18F]-fluorodeoxyglucose positron emission tomography (PET) data from 194 participants scanned under clamp conditions were compiled from a single-center cohort. BGU was quantified by the fractional uptake rate. We examined the association of age, sex,Mvalue from the clamp, steady-state insulin and free fatty acid levels, C-reactive protein levels, HbA1c, and presence of type 2 diabetes with BGU using Bayesian hierarchical modeling. RESULTS Insulin sensitivity, indexed by theMvalue, was associated negatively with BGU in all brain regions, confirming that in insulin-resistant participants BGU was enhanced during euglycemic hyperinsulinemia. In addition, the presence of type 2 diabetes was associated with additional increase in BGU. On the contrary, age was negatively related to BGU. Steady-state insulin levels, C-reactive protein and free fatty acid levels, sex, and HbA1c were not associated with BGU. CONCLUSIONS In this large cohort of participants of either sex across a wide range of age and insulin sensitivity, insulin sensitivity was the best predictor of BGU. © 2021 by the American Diabetes Association.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Bucci, MarcoUniversity of Turku, Turku, Finland (författare)
  • Karjalainen, TomiUniversity of Turku, Turku, Finland (författare)
  • Oikonen, VesaUniversity of Turku, Turku, Finland (författare)
  • Bertoldo, AlessandraUniversity of Padova, Padua, Italy (författare)
  • Hannukainen, Jarna C.University of Turku, Turku, Finland (författare)
  • Virtanen, Kirsi A.University of Turku, Turku, Finland; University of Eastern Finland, Kuopio, Finland (författare)
  • Latva-Rasku, AinoUniversity of Turku, Turku, Finland (författare)
  • Hirvonen, JussiTurku University Hospital, Turku, Finland; University of Turku, Turku, Finland (författare)
  • Heinonen, Ilkka,1982-Högskolan i Halmstad,Rydberglaboratoriet för tillämpad naturvetenskap (RLAS),University of Turku, Turku, Finland(Swepub:hh)ilkhei (författare)
  • Parkkola, RiittaTurku University Hospital, Turku, Finland; University of Turku, Turku, Finland (författare)
  • Laakso, MarkkuUniversity of Eastern Finland, Kuopio, Finland (författare)
  • Ferrannini, EleCNR, Pisa, Italy (författare)
  • Iozzo, PatriciaUniversity of Turku, Turku, Finland; CNR, Pisa, Italy (författare)
  • Nummenmaa, LauriUniversity of Turku, Turku, Finland (författare)
  • Nuutila, PirjoUniversity of Turku, Turku, Finland; Turku University Hospital, Turku, Finland (författare)
  • University of Turku, Turku, FinlandUniversity of Padova, Padua, Italy (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Diabetes CareArlington : American Diabetes Association Inc.44:3, s. 788-7940149-59921935-5548

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