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  • Garthwaite, TaruTurku University Hospital, Turku, Finland (författare)

Standing is associated with insulin sensitivity in adults with metabolic syndrome

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • Chatswood :Elsevier,2021
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:hh-45993
  • https://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-45993URI
  • https://doi.org/10.1016/j.jsams.2021.08.009DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • This work was supported by Academy of Finland; Finnish Cultural Foundation; Finnish Diabetes Research Foundation; Hospital District of Southwest Finland; and Juho Vainio Foundation. The study funders were not involved in the design of the study; the collection, analysis, and interpretation of data; writing the report; and did not impose any restrictions regarding the publication of the report.The authors regret an error in the fourth paragraph of the Methods section. This should read as follows:Whole-body insulin-stimulated glucose uptake (M-value) was measured with a hyperinsulinaemic–euglycaemic clamp after fasting overnight. Insulin (Actrapid, 100 U/ml, Novo Nordisk, Bagsvaerd, Denmark) was infused at a 160 mU/m2/min body surface area/min rate during the first 4 min, at 80 mU/m2/min during minutes 4–7, and thereafter at 40 mU/m2/min. Four minutes after starting insulin infusion, 20% glucose infusion was started. The rate was adjusted according to plasma glucose concentration measured every 5–10 min. M-value (μmol/kg/min) was calculated in 20-min intervals from steady-state glucose values. Fasting insulin and HOMA-IR were determined as surrogate markers of insulin sensitivity as described below. The authors regret any inconvenience caused. © 2022 The Author(s). Published by Elsevier Ltd on behalf of Sports Medicine Australia.
  • Objectives: To determine how components of accelerometer-measured sedentary behavior (SB) and physical activity (PA), and fitness are associated with insulin sensitivity in adults with metabolic syndrome. Design: Cross-sectional. Methods: Target population was middle-aged (40–65 years) sedentary adults with metabolic syndrome. SB, breaks in SB, standing, and PA were measured for four weeks with hip-worn accelerometers. VO2max (ml/min/kg) was measured with maximal cycle ergometry. Insulin sensitivity was determined by hyperinsulinaemic-euglycaemic clamp (M-value) and fasting blood sampling (HOMA-IR, insulin). Multivariable regression was used for analyses. Results: Sixty-four participants (37 women; 58.3 [SD 6.8] years) were included. Participants spent 10.0 (1.0) h sedentary, 1.8 (0.6) h standing, and 2.7 (0.6) h in PA and took 5149 (1825) steps and 29 (8) breaks daily. In sex-, age- and accelerometer wear time-adjusted model SB, standing, steps and VO2max were associated with M-value (β = −0.384; β = 0.400; β = 0.350; β = 0.609, respectively), HOMA-IR (β = 0.420; β = −0.548; β = −0.252; β = −0.449), and insulin (β = 0.433; β = −0.541; β = −0.252; β = −0.453); all p-values < 0.05. Breaks associated only with M-value (β = 0.277). When further adjusted for body fat %, only standing remained significantly associated with HOMA-IR (β = −0.381) and insulin (β = −0.366); significance was maintained even when further adjusted for SB, PA and fitness. Light and moderate-to-vigorous PA were not associated with insulin sensitivity. Conclusions: Standing is associated with insulin sensitivity markers. The association with HOMA-IR and insulin is independent of adiposity, PA, SB and fitness. Further studies are warranted, but these findings encourage replacing sitting with standing for potential improvements in insulin sensitivity in adults at increased type 2 diabetes risk. © 2021 The Authors.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Sjöros, TanjaTurku University Hospital, Turku, Finland (författare)
  • Koivumäki, MikkoTurku University Hospital, Turku, Finland (författare)
  • Laine, SaaraTurku University Hospital, Turku, Finland (författare)
  • Vähä-Ypyä, HenriUKK Institute Finland, Tampere, Finland (författare)
  • Saarenhovi, MariaTurku University Hospital, Turku, Finland (författare)
  • Kallio, PetriTurku University Hospital, Turku, Finland; University of Turku, Turku, Finland (författare)
  • Löyttyniemi, EliisaUniversity of Turku, Turku, Finland (författare)
  • Sievänen, HarriUKK Institute Finland, Tampere, Finland (författare)
  • Houttu, NooraUniversity of Turku, Turku, Finland (författare)
  • Laitinen, KirsiUniversity of Turku, Turku, Finland (författare)
  • Kalliokoski, KariTurku University Hospital, Turku, Finland (författare)
  • Vasankari, TommiUKK Institute Finland, Tampere, Finland; Tampere University, Tampere, Finland (författare)
  • Knuuti, JuhaniTurku University Hospital, Turku, Finland (författare)
  • Heinonen, Ilkka,1982-Högskolan i Halmstad,Rydberglaboratoriet för tillämpad naturvetenskap (RLAS),Turku University Hospital, Turku, Finland(Swepub:hh)ilkhei (författare)
  • Turku University Hospital, Turku, FinlandUKK Institute Finland, Tampere, Finland (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of Science and Medicine in SportChatswood : Elsevier24:12, s. 1255-12601440-24401878-1861

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