Search: WFRF:(Liu Shuwen)
> (2018) >
Inhibition of dengu...
Inhibition of dengue viral infection by diasarone-I is associated with 2'O methyltransferase of NS5
-
- Yao, Xingang (author)
- School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, PR China
-
- Ling, Yun (author)
- Department of Pharmaceutical and Life Sciences, Jiujiang University, Jiujiang, PR China
-
- Guo, Songxin (author)
- School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, PR China
-
show more...
-
- He, Shijun (author)
- School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, PR China
-
- Wang, Jinan (author)
- Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, PR China
-
- Zhang, Qing (author)
- Department of Pharmaceutical and Life Sciences, Jiujiang University, Jiujiang, PR China
-
- Wu, Wenyu (author)
- Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, PR China
-
- Zou, Min (author)
- School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, PR China
-
- Zhang, Tingting (author)
- School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, PR China
-
- Nandakumar, Kutty Selva, 1965- (author)
- School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, PR China
-
- Chen, Xiaoguang (author)
- School of Public Health, Southern Medical University, Southern Medical University, Guangzhou, PR China
-
- Liu, Shuwen (author)
- School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, PR China
-
show less...
-
(creator_code:org_t)
- Amsterdam : Elsevier, 2018
- 2018
- English.
-
In: European Journal of Pharmacology. - Amsterdam : Elsevier. - 0014-2999 .- 1879-0712. ; 821, s. 11-20
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Dengue virus (DENV) is the most prevalent mosquito borne viral pathogen worldwide. However, antiviral drugs against this infection are not available. To identify novel anti-DENV compound from traditional Chinese medicine, we discovered the ethanol extract of Acorus tatarinowii Schott containing potent anti-DENV activity and diasarone-I was isolated from this extract. Diasarone-I has antiviral effect with half maximal effective concentration (EC50) of 4.5μM and half maximal cytotoxicity concentration (CC50) of >80μM. Time of drug addition assay suggested that this compound inhibited at RNA replication step in the DENV life cycle. Further, in silico analysis indicated that diasarone-I might act as an inhibitor of 2'O Methyltransferase of NS5. Diasarone-I has also decreased the DENV2-induced STAT1 phosphorylation and ISGs. In summary, we suggest that diasarone-I may be a 2'O Methyltransferase inhibitor and might serve as a potential candidate for the treatment of DENV2 infections. © 2017 Elsevier B.V.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Keyword
- 2'O methyltransferase
- Acorus tatarinowii Schott
- DENV2
- Diasarone-I
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Yao, Xingang
-
Ling, Yun
-
Guo, Songxin
-
He, Shijun
-
Wang, Jinan
-
Zhang, Qing
-
show more...
-
Wu, Wenyu
-
Zou, Min
-
Zhang, Tingting
-
Nandakumar, Kutt ...
-
Chen, Xiaoguang
-
Liu, Shuwen
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Pharmaceutical S ...
- Articles in the publication
-
European Journal ...
- By the university
-
Halmstad University