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Bias and power in g...
Bias and power in group-based epidemiologic studies of low-back pain exposure and outcome : effects of study size and exposure measurement efforts
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- Coenen, Pieter (författare)
- Curtin University, Perth, Australia; VU University Amsterdam, the Netherlands; Body@Work, Research Center on Physical Activity, Work and Health, the Netherlands
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- Mathiassen, Svend Erik (författare)
- Högskolan i Gävle,Arbetshälsovetenskap,Centrum för belastningsskadeforskning
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- Kingma, Idsart (författare)
- VU University Amsterdam, the Netherlands; Body@Work, Research Center on Physical Activity, Work and Health, the Netherlands
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- Boot, Cécile (författare)
- Body@Work, Research Center on Physical Activity, Work and Health, the Netherlands; EMGO Institute, VU University Medical Center, Amsterdam, the Netherlands
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- Bongers, Paulien (författare)
- Body@Work, Research Center on Physical Activity, Work and Health, the Netherlands; TNO Healthy Living, Hoofddorp, the Netherlands
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- van Dieën, Jaap (författare)
- VU University Amsterdam, the Netherlands; King Abdulaziz University,Jeddah, Saudi Arabia
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(creator_code:org_t)
- 2014-11-27
- 2015
- Engelska.
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Ingår i: Annals of Occupational Hygiene. - : Oxford University Press (OUP). - 0003-4878 .- 1475-3162. ; 59:4, s. 439-454
- Relaterad länk:
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Objectives: Exposure-outcome studies, for instance on work-related low-back pain (LBP), often classify workers into groups for which exposures are estimated from measurements on a sample of workers within or outside the specific study. The present study investigated the influence on bias and power in exposure-outcome associations of the sizes of the total study population and the sample used to estimate exposures.Methods: At baseline, lifting, trunk flexion, and trunk rotation were observed for 371 of 1131 workers allocated to 19 a-priori defined occupational groups. LBP (dichotomous) was reported by all workers during three years of follow-up. All three exposures were associated with LBP in this parent study (p<0.01).All 21 combinations of n=10,20,30 workers per group with an outcome, and k=1,2,3,5,10,15,20 workers actually being observed were investigated using bootstrapping, repeating each combination 10,000 times. Odds ratios (OR) with p-values were determined for each of these virtual studies. Average OR and statistical power (p<0.05 and p<0.01) was determined from the bootstrap distributions at each (n,k) combination.Results: For lifting and flexed trunk, studies including n≥20 workers, with k≥5 observed, led to an almost unbiased OR and a power >0.80 (p-level 0.05). A similar performance required n≥30 workers for rotated trunk. Small numbers of observed workers (k) resulted in biased OR, while power was, in general, more sensitive to the total number of workers (n).Conclusions: In epidemiologic studies using a group-based exposure assessment strategy, statistical performance may be sufficient if outcome is obtained from a reasonably large number of workers, even if exposure is estimated from only few workers per group.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Nyckelord
- epidemiology
- ergonomics
- exposure
- exposure assessment
- group-based measurement strategy
- low-back pain
- musculoskeletal injury
- precision
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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