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Complete Clinical R...
Complete Clinical Remission of Stage IV Triple-Negative Breast Cancer Lung Metastasis Administering Low-Dose Immune Checkpoint Blockade in Combination With Hyperthermia and Interleukin-2
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- Kleef, Ralf (author)
- Dr. Kleef hyperthermie
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- Moss, Ralph (author)
- Cancer Decisions, Lermont
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- Szasz, A. Marcell (author)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Protein Science and Imaging,Forskargrupper vid Lunds universitet,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Semmelweis University
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- Bohdjalian, Arthur (author)
- Rudolfinerhaus, Vienna
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- Bojar, Hans (author)
- NextGen Oncology Group, Düsseldorf
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- Bakacs, Tibor (author)
- PRET Therapeutics Ltd, Budapest
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Dr Kleef hyperthermie Cancer Decisions, Lermont (creator_code:org_t)
- 2018-09-07
- 2018
- English 7 s.
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In: Integrative Cancer Therapies. - : SAGE Publications. - 1534-7354 .- 1552-695X. ; 17:4, s. 1297-1303
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Abstract
Subject headings
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- The prognosis of triple-negative breast cancer with metastases after chemotherapy remains dismal. We report the case of a 50-year-old female with first disease recurrence at the axillary lymph node and, later on, bilateral pulmonary metastases with severe shortness of breath. The patient received low-dose immune checkpoint blockade (concurrent nivolumab and ipilimumab) weekly over 3 weeks with regional hyperthermia 3 times a week, followed by systemic fever-range hyperthermia induced by interleukin-2 for 5 days. She went into complete remission of her pulmonary metastases with transient WHO I-II diarrhea and skin rash. The patient remained alive for 27 months after the start of treatment, with recurrence of metastases as a sternal mass, and up to 3 cm pleural metastases. This exceptional response should instigate further research efforts with this protocol, which consists only of approved drugs and treatments.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- checkpoint inhibition
- hyperthermia
- IL-2
- immunotherapy
- TNBC
Publication and Content Type
- art (subject category)
- ref (subject category)
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