EVALUATION OF THE HEMOCOMPATIBILITY OF NOVEL POLYMERIC MATERIALS

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Engberg, Anna E.,1982-Högskolan i Kalmar,Naturvetenskapliga institutionen,Kristina Nilsson Ekdahl (author)

EVALUATION OF THE HEMOCOMPATIBILITY OF NOVEL POLYMERIC MATERIALS

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LIBRIS-ID:oai:DiVA.org:hik-2792
https://urn.kb.se/resolve?urn=urn:nbn:se:hik:diva-2792URI

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Language:English
Summary in:English

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Subject category:ovr swepub-publicationtype

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When a biomaterial surface comes in contact with blood an immediate adsorption of plasma proteins to the surface will occur, and the cascade systems in the blood, such as the complement, coagulation and contact system, will be activated to various degrees. The intensity of this reaction will determine the hemocompatibility of the materials. Here we present an evaluation of the link between the composition, the physico-chemical properties and the protein adsorption properties of six newly synthesized polymers (P1-P6) and the hemocompatibility.The hemocompatibility of the polymeric surfaces was evaluated in human blood plasma and whole blood. Commercially available polyvinylchloride (PVC) was used as reference material. The hemocompatibility of the polymeric surfaces was evaluated with regard to complement activation (C3a and sC5-9 generation) and coagulation activation (platelet loss and TAT-formation) and cytokine productions (27 analytes in multiplex assay) after contact with whole blood. Contact activation was quantified by analyses of FXIIa-C1INH, FXIa-C1INH, and kallikrein-C1INH complexes.Polymers P2 (p<0.05 for C3a), P3, P5 and P6 showed less complement activation, and polymers P1 and P4 (p<0.05 for platelet loss), as well as P5 and P6 showed less coagulation activation compared with reference PVC. Polymers P1-P3 induced activation of the contact system, P3 being the most potent. Secretion of 17 cytokines including chemokines and growth factors were differentially influenced by the polymers, P1 and P3 being significantly (p<0.05) more compatible for five of the analytes.Collectively these data demonstrate that the composition of the polymers clearly leads to different biological properties as a consequence of distinctive physico-chemical properties and protein adsorption patterns.1

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Immunologi inom det medicinska området hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Immunology in the medical area hsv//eng
Polymers
biomaterials
whole blood
complement
coagulation
contact activation
cytokines
hemocompatibility
Immunology
Immunologi
Biomedicinsk vetenskap
Biomedical Sciences

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Rosengren-Holmberg, Jenny PHögskolan i Kalmar,Naturvetenskapliga institutionen(Swepub:lnu)nroje (author)
Nilsson, Per H.Högskolan i Kalmar,Naturvetenskapliga institutionen(Swepub:lnu)enipe (author)
Mollnes, Tom EirikInstitute of Immunology, Rikshospitalet University Hospital, Oslo, Norway,Research Laboratory, Nordland Hospital, Bodø, and University of Tromsø, Norway (author)
Nicholls, Ian A.Högskolan i Kalmar,Naturvetenskapliga institutionen(Swepub:lnu)nniia (author)
Nilsson, BoDepartment of Oncology, Radiology and Clinical Immunology, Section of Clinical Immunology, Rudbeck Laboratory C5, Uppsala University Hospital, SE-751 85 Uppsala, Sweden (author)
Nilsson Ekdahl, KristinaHögskolan i Kalmar,Naturvetenskapliga institutionen(Swepub:lnu)nnikr (author)
Högskolan i KalmarNaturvetenskapliga institutionen (creator_code:org_t)

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Immunology in th ...

By the university: Linnaeus University

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