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Non-Invasive Acoust...
Non-Invasive Acoustical sensing of Drug-Induced Effects on the Contractile Machinery of Human Cardiomyocyte Clusters
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- Kunze, Angelika, 1978 (författare)
- Department of Applied Physics, Chalmers University of Technology, Göteborg, Sweden / Institute of Physical Chemistry, University of Göttingen, Göttingen, Germany,Chalmers tekniska högskola,Chalmers University of Technology
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- Steel, Daniella (författare)
- Cellectis AB, Göteborg, Sweden / Abcam, Cambridge, United Kingdom,Abcam plc
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- Dahlenborg, Kerstin (författare)
- Cellectis AB, Göteborg, Sweden
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- Sartipy, Peter (författare)
- Högskolan i Skövde,Institutionen för biovetenskap,Forskningscentrum för Systembiologi,Cellectis AB, Göteborg, Sweden / AstraZeneca R&D, Mölndal, Sweden,Bioinformatik, Bioinformatics,University of Skövde,AstraZeneca AB
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- Svedhem, Sofia, 1970 (författare)
- Department of Applied Physics, Chalmers University of Technology, Göteborg, Sweden,Chalmers tekniska högskola,Chalmers University of Technology
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(creator_code:org_t)
- 2015-05-11
- 2015
- Engelska.
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Ingår i: PLOS ONE. - : Public Library of Science. - 1932-6203. ; 10:5, s. 1-10
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- There is an urgent need for improved models for cardiotoxicity testing. Here we propose acoustic sensing applied to beating human cardiomyocyte clusters for non-invasive, surrogate measuring of the QT interval and other characteristics of the contractile machinery. In experiments with the acoustic method quartz crystal microbalance with dissipation monitoring (QCM-D), the shape of the recorded signals was very similar to the extracellular field potential detected in electrochemical experiments, and the expected changes of the QT interval in response to addition of conventional drugs (E-4031 or nifedipine) were observed. Additionally, changes in the dissipation signal upon addition of cytochalasin D were in good agreement with the known, corresponding shortening of the contraction-relaxation time. These findings suggest that QCM-D has great potential as a tool for cardiotoxicological screening, where effects of compounds on the cardiomyocyte contractile machinery can be detected independently of whether the extracellular field potential is altered or not.
Ämnesord
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Annan teknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Other Engineering and Technologies (hsv//eng)
- NATURVETENSKAP -- Kemi -- Analytisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Analytical Chemistry (hsv//eng)
Nyckelord
- Bioinformatik
- Bioinformatics
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