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Blood pressure regu...
Blood pressure regulation by CD4+ lymphocytes expressing choline acetyltransferase
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- Olofsson, Peder S. (author)
- Karolinska Institutet,Center for Bioelectronic Medicine, Department of Medicine, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden / Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, Manhasset, New York, USA
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- Steinberg, Benjamin E. (author)
- Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, Manhasset, New York, USA / The Campbell Family Institute for Breast Cancer Research, University Health Network, Toronto, Ontario, Canada
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- Sobbi, Roozbeh (author)
- Division of Cardiology, Peter Munk Cardiac Centre, University Health Network, Toronto, Ontario, Canada
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- Cox, Maureen A. (author)
- The Campbell Family Institute for Breast Cancer Research, University Health Network, Toronto, Ontario, Canada,Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
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- Ahmed, Mohamed N. (author)
- Center for Heart and Lung Research, The Feinstein Institute for Medical Research, Manhasset, New York, USA
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- Oswald, Michaela (author)
- Robert S. Boas Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, New York, USA
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- Szekeres, Ferenc (author)
- Högskolan i Skövde,Institutionen för hälsa och lärande,Forskningsspecialiseringen Hälsa och Lärande,Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden,Äldre och långvariga hälsoproblem, Health and Ageing
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- Hanes, William M. (author)
- Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, Manhasset, New York, USA
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- Introini, Andrea (author)
- Karolinska Institutet,Department of Medicine, Solna, Unit of Infectious Diseases, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
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- Liu, Shu Fang (author)
- Center for Heart and Lung Research, The Feinstein Institute for Medical Research, Manhasset, New York, USA
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- Holodick, Nichol E. (author)
- Center for Oncology and Cell Biology, The Feinstein Institute for Medical Research, Manhasset, New York, USA
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- Rothstein, Thomas L. (author)
- Center for Oncology and Cell Biology, The Feinstein Institute for Medical Research, Manhasset, New York, USA
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- Lövdahl, Cecilia (author)
- Karolinska Institutet,Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
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- Chavan, Sangeeta S. (author)
- Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, Manhasset, New York, USA
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- Yang, Huan (author)
- Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, Manhasset, New York, USA
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- Pavlov, Valentin A. (author)
- Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, Manhasset, New York, USA
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- Broliden, Kristina (author)
- Karolinska Institutet,Department of Medicine, Solna, Unit of Infectious Diseases, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
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- Andersson, Ulf (author)
- Karolinska Institutet,Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden
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- Diamond, Betty (author)
- The Center for Autoimmune and Musculoskeletal Diseases, The Feinstein Institute for Medical Research, Manhasset, New York, USA
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- Miller, Edmund J. (author)
- Center for Heart and Lung Research, The Feinstein Institute for Medical Research, Manhasset, New York, USA
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- Arner, Anders (author)
- Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
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- Gregersen, Peter K. (author)
- Robert S. Boas Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, New York, USA
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- Backx, Peter H. (author)
- Division of Cardiology, Peter Munk Cardiac Centre, University Health Network, Toronto, Ontario, Canada / Department of Biology, York University, Toronto, Ontario, Canada
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- Mak, Tak W. (author)
- The Campbell Family Institute for Breast Cancer Research, University Health Network, Toronto, Ontario, Canada
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- Tracey, Kevin J. (author)
- Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, Manhasset, New York, USA
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(creator_code:org_t)
- 2016-09-12
- 2016
- English.
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In: Nature Biotechnology. - : Nature Publishing Group. - 1087-0156 .- 1546-1696. ; 34:10, s. 1066-1071
- Related links:
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https://europepmc.or...
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Abstract
Subject headings
Close
- Blood pressure regulation is known to be maintained by a neuro-endocrine circuit, but whether immune cells contribute to blood pressure homeostasis has not been determined. We previously showed that CD4(+) T lymphocytes that express choline acetyltransferase (ChAT), which catalyzes the synthesis of the vasorelaxant acetylcholine, relay neural signals(1). Here we show that these CD4(+)CD44(hi)CD62L(Io) T helper cells by gene expression are a distinct T-cell population defined by ChAT (CD4 T-ChAT). Mice lacking ChAT expression in CD4(+) cells have elevated arterial blood pressure, compared to littermate controls. Jurkat T cells overexpressing ChAT (JT(ChAT)) decreased blood pressure when infused into mice. Co-incubation of JT(ChAT) and endothelial cells increased endothelial cell levels of phosphorylated endothelial nitric oxide synthase, and of nitrates and nitrites in conditioned media, indicating increased release of the potent vasorelaxant nitric oxide. The isolation and characterization of CD4 T-ChAT cells will enable analysis of the role of these cells in hypotension and hypertension, and may suggest novel therapeutic strategies by targeting cell-mediated vasorelaxation.
Subject headings
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- CD4-positive T cells
- Experimental models of disease
- Hypertension
- Mechanisms of disease
- Neuro–vascular interactions
- Äldre och åldrande
- Age and Ageing
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Olofsson, Peder ...
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Steinberg, Benja ...
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Sobbi, Roozbeh
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Cox, Maureen A.
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Ahmed, Mohamed N ...
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Oswald, Michaela
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show more...
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Szekeres, Ferenc
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Hanes, William M ...
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Introini, Andrea
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Liu, Shu Fang
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Holodick, Nichol ...
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Rothstein, Thoma ...
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Lövdahl, Cecilia
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Chavan, Sangeeta ...
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Yang, Huan
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Pavlov, Valentin ...
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Broliden, Kristi ...
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Andersson, Ulf
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Diamond, Betty
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Miller, Edmund J ...
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Arner, Anders
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Gregersen, Peter ...
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Backx, Peter H.
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Mak, Tak W.
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Tracey, Kevin J.
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and Biological Scien ...
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and Cell Biology
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University of Skövde
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Karolinska Institutet