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Adding high-intensi...
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Mijwel, SaraKarolinska Institutet
(författare)
Adding high-intensity interval training to conventional training modalities : optimizing health-related outcomes during chemotherapy for breast cancer: the OptiTrain randomized controlled trial
- Artikel/kapitelEngelska2018
Förlag, utgivningsår, omfång ...
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2017-11-14
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Springer,2018
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:his-14988
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https://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-14988URI
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https://doi.org/10.1007/s10549-017-4571-3DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-39224URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:gih:diva-7704URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:137784390URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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CC BY 4.0
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PURPOSE: Exercise training is an effective and safe way to counteract cancer-related fatigue (CRF) and to improve health-related quality of life (HRQoL). High-intensity interval training has proven beneficial for the health of clinical populations. The aim of this randomized controlled trial was to compare the effects of resistance and high-intensity interval training (RT-HIIT), and moderate-intensity aerobic and high-intensity interval training (AT-HIIT) to usual care (UC) in women with breast cancer undergoing chemotherapy. The primary endpoint was CRF and the secondary endpoints were HRQoL and cancer treatment-related symptoms.METHODS: Two hundred and forty women planned to undergo chemotherapy were randomized to supervised RT-HIIT, AT-HIIT, or UC. Measurements were performed at baseline and at 16 weeks. Questionnaires included Piper Fatigue Scale, EORTC-QLQ-C30, and Memorial Symptom Assessment Scale.RESULTS: The RT-HIIT group was superior to UC for CRF: total CRF (p = 0.02), behavior/daily life (p = 0.01), and sensory/physical (p = 0.03) CRF. Role functioning significantly improved while cognitive functioning was unchanged for RT-HIIT compared to declines shown in the UC group (p = 0.04). AT-HIIT significantly improved emotional functioning versus UC (p = 0.01) and was superior to UC for pain symptoms (p = 0.03). RT-HIIT reported a reduced symptom burden, while AT-HIIT remained stable compared to deteriorations shown by UC (p < 0.01). Only RT-HIIT was superior to UC for total symptoms (p < 0.01).CONCLUSIONS: 16 weeks of resistance and HIIT was effective in preventing increases in CRF and in reducing symptom burden for patients during chemotherapy for breast cancer. These findings add to a growing body of evidence supporting the inclusion of structured exercise prescriptions, including HIIT, as a vital component of cancer rehabilitation.TRIAL REGISTRATION: Clinicaltrials.gov Registration Number: NCT02522260.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Backman, MalinKarolinska Institutet
(författare)
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Bolam, KateKarolinska Institutet(Swepub:gih)kate.bolam
(författare)
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Jervaeus, AnnaKarolinska Institutet
(författare)
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Sundberg, Carl JohanKarolinska Institutet
(författare)
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Margolin, SaraKarolinska Institutet
(författare)
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Browall, MariaJönköping University,Högskolan i Skövde,Institutionen för hälsa och lärande,Forskningsspecialiseringen Hälsa och Lärande,Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden,Välbefinnande vid långvariga hälsoproblem, Wellbeing in long-term health problems (WeLHP),HHJ, Avdelningen för omvårdnad,HHJ. IMPROVE (Improvement, innovation, and leadership in health and welfare),Högskolan i Skövde, Institutionen för hälsa och lärande(Swepub:hj)giomar
(författare)
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Rundqvist, HeleneKarolinska Institutet
(författare)
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Wengström, YvonneKarolinska Institutet
(författare)
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Karolinska InstitutetInstitutionen för hälsa och lärande
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Breast Cancer Research and Treatment: Springer168:1, s. 79-930167-68061573-7217
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