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Sökning: id:"swepub:oai:DiVA.org:his-14988" > Adding high-intensi...

  • Mijwel, SaraKarolinska Institutet (författare)

Adding high-intensity interval training to conventional training modalities : optimizing health-related outcomes during chemotherapy for breast cancer: the OptiTrain randomized controlled trial

  • Artikel/kapitelEngelska2018

Förlag, utgivningsår, omfång ...

  • 2017-11-14
  • Springer,2018
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:his-14988
  • https://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-14988URI
  • https://doi.org/10.1007/s10549-017-4571-3DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-39224URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:gih:diva-7704URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:137784390URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • CC BY 4.0
  • PURPOSE: Exercise training is an effective and safe way to counteract cancer-related fatigue (CRF) and to improve health-related quality of life (HRQoL). High-intensity interval training has proven beneficial for the health of clinical populations. The aim of this randomized controlled trial was to compare the effects of resistance and high-intensity interval training (RT-HIIT), and moderate-intensity aerobic and high-intensity interval training (AT-HIIT) to usual care (UC) in women with breast cancer undergoing chemotherapy. The primary endpoint was CRF and the secondary endpoints were HRQoL and cancer treatment-related symptoms.METHODS: Two hundred and forty women planned to undergo chemotherapy were randomized to supervised RT-HIIT, AT-HIIT, or UC. Measurements were performed at baseline and at 16 weeks. Questionnaires included Piper Fatigue Scale, EORTC-QLQ-C30, and Memorial Symptom Assessment Scale.RESULTS: The RT-HIIT group was superior to UC for CRF: total CRF (p = 0.02), behavior/daily life (p = 0.01), and sensory/physical (p = 0.03) CRF. Role functioning significantly improved while cognitive functioning was unchanged for RT-HIIT compared to declines shown in the UC group (p = 0.04). AT-HIIT significantly improved emotional functioning versus UC (p = 0.01) and was superior to UC for pain symptoms (p = 0.03). RT-HIIT reported a reduced symptom burden, while AT-HIIT remained stable compared to deteriorations shown by UC (p < 0.01). Only RT-HIIT was superior to UC for total symptoms (p < 0.01).CONCLUSIONS: 16 weeks of resistance and HIIT was effective in preventing increases in CRF and in reducing symptom burden for patients during chemotherapy for breast cancer. These findings add to a growing body of evidence supporting the inclusion of structured exercise prescriptions, including HIIT, as a vital component of cancer rehabilitation.TRIAL REGISTRATION: Clinicaltrials.gov Registration Number: NCT02522260.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Backman, MalinKarolinska Institutet (författare)
  • Bolam, KateKarolinska Institutet(Swepub:gih)kate.bolam (författare)
  • Jervaeus, AnnaKarolinska Institutet (författare)
  • Sundberg, Carl JohanKarolinska Institutet (författare)
  • Margolin, SaraKarolinska Institutet (författare)
  • Browall, MariaJönköping University,Högskolan i Skövde,Institutionen för hälsa och lärande,Forskningsspecialiseringen Hälsa och Lärande,Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden,Välbefinnande vid långvariga hälsoproblem, Wellbeing in long-term health problems (WeLHP),HHJ, Avdelningen för omvårdnad,HHJ. IMPROVE (Improvement, innovation, and leadership in health and welfare),Högskolan i Skövde, Institutionen för hälsa och lärande(Swepub:hj)giomar (författare)
  • Rundqvist, HeleneKarolinska Institutet (författare)
  • Wengström, YvonneKarolinska Institutet (författare)
  • Karolinska InstitutetInstitutionen för hälsa och lärande (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Breast Cancer Research and Treatment: Springer168:1, s. 79-930167-68061573-7217

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