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Physical inactivity...
Physical inactivity, cardiometabolic disease, and risk of dementia : an individual-participant meta-analysis
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- Kivimäki, Mika (författare)
- UCL, Dept Epidemiol & Publ Hlth, London WC1E 6BT, England;Univ Helsinki, Clinicum, Fac Med, FI-00014 Helsinki, Finland;Univ Helsinki, Helsinki Inst Life Sci, Helsinki, Finland
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- Singh-Manoux, Archana (författare)
- UCL, Dept Epidemiol & Publ Hlth, London WC1E 6BT, England;INSERM, U1153, Epidemiol Ageing & Neurodegenerat Dis, Paris, France,UCL, London, England; INSERM, Paris, France
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- Pentti, Jaana (författare)
- Univ Helsinki, Clinicum, Fac Med, FI-00014 Helsinki, Finland;Univ Turku, Dept Publ Hlth, Turku, Finland
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- Sabia, Séverine (författare)
- UCL, Dept Epidemiol & Publ Hlth, London WC1E 6BT, England;INSERM, U1153, Epidemiol Ageing & Neurodegenerat Dis, Paris, France,UCL, London, England; INSERM, Paris, France
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- Theorell, Töres (författare)
- Karolinska Institutet,Stockholms universitet,Stressforskningsinstitutet,Univ Helsinki, Clinicum, Fac Med, FI-00014 Helsinki, Finland,Stockholm Univ, Stress Res Inst, Stockholm, Sweden
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- Alfredsson, Lars (författare)
- Karolinska Institutet,Karolinska Inst, Inst Environm Med, Stockholm, Sweden
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- Goldberg, Marcel (författare)
- INSERM, UMS 011, Populat Based Epidemiol Cohorts Unit, Villejuif, France
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- Knutsson, Anders, 1942- (författare)
- Mittuniversitetet,Institutionen för hälsovetenskap,Mid Sweden Univ, Dept Hlth Sci, Sundsvall, Sweden
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- Koskenvuo, Markku (författare)
- Univ Helsinki, Clinicum, Fac Med, FI-00014 Helsinki, Finland
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- Koskinen, Aki (författare)
- Finnish Inst Occupat Hlth, Helsinki, Finland
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- Kouvonen, Anne (författare)
- Univ Helsinki, Fac Social Sci, Helsinki, Finland;SWPS Univ Social Sci & Humanities Wroclaw, Wroclaw, Poland;Queens Univ Belfast, Ctr Publ Hlth, Adm Data Res Ctr Northern Ireland, Belfast, Antrim, North Ireland
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- Nordin, Maria (författare)
- Stockholms universitet,Umeå universitet,Institutionen för psykologi,Stockholm Univ, Stress Res Inst, Stockholm, Sweden;Umea Univ, Dept Psychol, Umea, Sweden,Stressforskningsinstitutet,Umeå University, Sweden
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- Oksanen, Tuula (författare)
- Finnish Inst Occupat Hlth, Helsinki, Finland
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- Strandberg, Timo (författare)
- Univ Helsinki, Clinicum, Fac Med, FI-00014 Helsinki, Finland;Helsinki Univ Hosp, Helsinki, Finland;Univ Oulu, Ctr Life Course Hlth Res, Oulu, Finland
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- Suominen, Sakari (författare)
- Högskolan i Skövde,Institutionen för hälsa och lärande,Forskningsspecialiseringen Hälsa och Lärande,Univ Turku, Dept Publ Hlth, Turku, Finland;Univ Skovde, Skovde, Sweden,Individ och samhälle VIDSOC,Univ Turku, Turku, Finland; Univ Skövde, Skövde
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- Theorell, Töres (författare)
- Stockholm Univ, Stress Res Inst, Sweden
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- Vahtera, Jussi (författare)
- Univ Turku, Dept Publ Hlth, Turku, Finland;Turku Univ Hosp, Turku, Finland
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- Väänanen, Ari (författare)
- Finnish Inst Occupat Hlth, Helsinki, Finland
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- Virtanen, Marianna (författare)
- Univ Eastern Finland, Sch Educ Sci & Psychol, Joensuu, Finland
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- Westerholm, Peter (författare)
- Uppsala universitet,Arbets- och miljömedicin
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- Westerlund, Hugo (författare)
- Karolinska Institutet,Stockholms universitet,Stressforskningsinstitutet,Stockholm Univ, Stress Res Inst, Stockholm, Sweden
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- Zins, Marie (författare)
- INSERM, UMS 011, Populat Based Epidemiol Cohorts Unit, Villejuif, France
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- Seshadri, Sudha (författare)
- Univ Texas Hlth Sci Ctr San Antonio, Glenn Biggs Inst Alzheimers & Neurodegenerat Dis, San Antonio, TX 78229 USA / Framingham Heart Dis Epidemiol Study, Framingham, MA USA
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- Batty, G. David (författare)
- UCL, Dept Epidemiol & Publ Hlth, London WC1E 6BT, England
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- Sipilä, Pyry N. (författare)
- Univ Bristol, Bristol Med Sch, Populat Hlth Sci, Bristol, Avon, England
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- Shipley, Martin J. (författare)
- UCL, Dept Epidemiol & Publ Hlth, London WC1E 6BT, England
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- Lindbohm, Joni V. (författare)
- Univ Helsinki, Clinicum, Fac Med, FI-00014 Helsinki, Finland
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- Ferrie, Jane E. (författare)
- UCL, Dept Epidemiol & Publ Hlth, London WC1E 6BT, England / Univ Bristol, Bristol Med Sch, Populat Hlth Sci, Bristol, Avon, England
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- Jokela, Markus (författare)
- Univ Helsinki, Biomedicum, Fac Med, Helsinki, Finland
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(creator_code:org_t)
- 2019-04-17
- 2019
- Engelska.
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Ingår i: The BMJ. - ENGLAND : BMJ Publishing Group Ltd. - 1756-1833 .- 0959-8138. ; 365
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- OBJECTIVE To examine whether physical inactivity is a risk factor for dementia, with attention to the role of cardiometabolic disease in this association and reverse causation bias that arises from changes in physical activity in the preclinical (prodromal) phase of dementia. DESIGN Meta-analysis of 19 prospective observational cohort studies. DATA SOURCES The Individual-Participant-Data Meta-analysis in Working Populations Consortium, the Inter-University Consortium for Political and Social Research, and the UK Data Service, including a total of 19 of a potential 9741 studies. REVIEW METHOD The search strategy was designed to retrieve individual-participant data from prospective cohort studies. Exposure was physical inactivity; primary outcomes were incident all-cause dementia and Alzheimer's disease; and the secondary outcome was incident cardiometabolic disease (that is, diabetes, coronary heart disease, and stroke). Summary estimates were obtained using random effects meta-analysis. RESULTS Study population included 404 840 people (mean age 45.5 years, 57.7% women) who were initially free of dementia, had a measurement of physical inactivity at study entry, and were linked to electronic health records. In 6.0 million person-years at risk, we recorded 2044 incident cases of all-cause dementia. In studies with data on dementia subtype, the number of incident cases of Alzheimer's disease was 1602 in 5.2 million person-years. When measured < 10 years before dementia diagnosis (that is, the preclinical stage of dementia), physical inactivity was associated with increased incidence of all-cause dementia (hazard ratio 1.40, 95% confidence interval 1.23 to 1.71) and Alzheimer's disease (1.36, 1.12 to 1.65). When reverse causation was minimised by assessing physical activity >= 10 years before dementia onset, no difference in dementia risk between physically active and inactive participants was observed (hazard ratios 1.01 (0.89 to 1.14) and 0.96 (0.85 to 1.08) for the two outcomes). Physical inactivity was consistently associated with increased risk of incident diabetes (hazard ratio 1.42, 1.25 to 1.61), coronary heart disease (1.24, 1.13 to 1.36), and stroke (1.16, 1.05 to 1.27). Among people in whom cardiometabolic disease preceded dementia, physical inactivity was non-significantly associated with dementia (hazard ratio for physical activity assessed > 10 before dementia onset 1.30, 0.79 to 2.14). CONCLUSIONS In analyses that addressed bias due to reverse causation, physical inactivity was not associated with all-cause dementia or Alzheimer's disease, although an indication of excess dementia risk was observed in a subgroup of physically inactive individuals who developed cardiometabolic disease.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences (hsv//eng)
Nyckelord
- job strain
- proportional-hazards
- heart-disease
- life-style
- follow-up
- cohort
- time
- men
- association
- mortality
- Individual and Society VIDSOC
- Individ och samhälle VIDSOC
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Kivimäki, Mika
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Singh-Manoux, Ar ...
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Pentti, Jaana
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Sabia, Séverine
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Theorell, Töres
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Alfredsson, Lars
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Goldberg, Marcel
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Knutsson, Anders ...
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Koskenvuo, Markk ...
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Koskinen, Aki
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Kouvonen, Anne
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Nordin, Maria
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Oksanen, Tuula
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Strandberg, Timo
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Suominen, Sakari
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Vahtera, Jussi
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Väänanen, Ari
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Virtanen, Marian ...
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Westerholm, Pete ...
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Westerlund, Hugo
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Zins, Marie
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Seshadri, Sudha
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Batty, G. David
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Sipilä, Pyry N.
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Shipley, Martin ...
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Lindbohm, Joni V ...
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Ferrie, Jane E.
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Jokela, Markus
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