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Therapeutic efficac...
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Carlström, Karl E.Karolinska Institutet,Department of Clinical Neurosciences, Section of Neurology, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Sweden
(författare)
Therapeutic efficacy of dimethyl fumarate in relapsing-remitting multiple sclerosis associates with ROS pathway in monocytes
- Artikel/kapitelEngelska2019
Förlag, utgivningsår, omfång ...
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2019-07-12
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Nature Publishing Group,2019
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:his-17478
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https://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-17478URI
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https://doi.org/10.1038/s41467-019-11139-3DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:141347206URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-159141URI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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CC BY 4.0
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Funding Agencies|Swedish Medical Research Council [2017-03054]; Stockholm County [20170216]; Biogen; Hjarnfonden; NEURO Forbundet; Karolinska Thematic Center in Inflammation
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Dimethyl fumarate (DMF) is a first-line-treatment for relapsing-remitting multiple sclerosis (RRMS). The redox master regulator Nrf2, essential for redox balance, is a target of DMF, but its precise therapeutic mechanisms of action remain elusive. Here we show impact of DMF on circulating monocytes and T cells in a prospective longitudinal RRMS patient cohort. DMF increases the level of oxidized isoprostanes in peripheral blood. Other observed changes, including methylome and transcriptome profiles, occur in monocytes prior to T cells. Importantly, monocyte counts and monocytic ROS increase following DMF and distinguish patients with beneficial treatment-response from non-responders. A single nucleotide polymorphism in the ROS-generating NOX3 gene is associated with beneficial DMF treatment-response. Our data implicate monocyte-derived oxidative processes in autoimmune diseases and their treatment, and identify NOX3 genetic variant, monocyte counts and redox state as parameters potentially useful to inform clinical decisions on DMF therapy of RRMS.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Ewing, EwoudKarolinska Institutet,Division of Physiological Chemistry II, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Sweden
(författare)
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Granqvist, MathiasKarolinska Institutet,Department of Clinical Neurosciences, Section of Neurology, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Sweden
(författare)
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Gyllenberg, AlexandraKarolinska Institutet,Department of Clinical Neurosciences, Section of Neurology, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Sweden
(författare)
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Aeinehband, ShahinDepartment of Clinical Neurosciences, Section of Neurology, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Sweden
(författare)
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Enoksson, Sara LindKarolinska Institutet,Department of Clinical Immunology Karolinska University Hospital, Stockholm, Sweden,Karolinska Univ Hosp, Sweden
(författare)
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Checa, AntonioKarolinska Institutet,Division of Physiological Chemistry II, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Sweden
(författare)
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Badam, TejaswiLinköpings universitet,Högskolan i Skövde,Institutionen för biovetenskap,Forskningscentrum för Systembiologi,Department of Physics, Chemistry & Biology (IFM), Bioinformatics, Linköping University, Sweden,Translationell Bioinformatik, Translational Bioinformatics,Bioinformatik,Tekniska fakulteten,Univ Skovde, Sweden(Swepub:liu)tejba58
(författare)
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Huang, JesseDepartment of Clinical Neurosciences, Section of Neurology, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Sweden
(författare)
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Gomez-Cabrero, DavidKarolinska Institutet,Translational Bioinformatics Unit, Navarrabiomed, Complejo Hospitalario de Navarra (CHN), Universidad Publica de Nevarra (UPNA), IdiSNA, Pamplona, Spain,Univ Publ Nevarra UPNA, Spain
(författare)
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Gustafsson, MikaLinköpings universitet,Bioinformatik,Tekniska fakulteten(Swepub:liu)mikgu75
(författare)
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Al Nimer, FaiezKarolinska Institutet,Department of Clinical Neurosciences, Section of Neurology, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Sweden
(författare)
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Wheelock, Craig E.Division of Physiological Chemistry II, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
(författare)
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Kockum, IngridKarolinska Institutet,Department of Clinical Neurosciences, Section of Neurology, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Sweden
(författare)
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Olsson, TomasKarolinska Institutet,Department of Clinical Neurosciences, Section of Neurology, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Sweden
(författare)
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Jagodic, MajaKarolinska Institutet,Department of Clinical Neurosciences, Section of Neurology, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Sweden
(författare)
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Piehl, FredrikKarolinska Institutet,Department of Clinical Neurosciences, Section of Neurology, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Sweden
(författare)
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Karolinska InstitutetDepartment of Clinical Neurosciences, Section of Neurology, Karolinska Institutet, Stockholm, Sweden
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Nature Communications: Nature Publishing Group10:1, s. 1-132041-1723
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Till lärosätets databas
- Av författaren/redakt...
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Carlström, Karl ...
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Ewing, Ewoud
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Granqvist, Mathi ...
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Gyllenberg, Alex ...
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Aeinehband, Shah ...
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Enoksson, Sara L ...
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visa fler...
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Checa, Antonio
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Badam, Tejaswi
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Huang, Jesse
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Gomez-Cabrero, D ...
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Gustafsson, Mika
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Al Nimer, Faiez
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Wheelock, Craig ...
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Kockum, Ingrid
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Olsson, Tomas
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Jagodic, Maja
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Piehl, Fredrik
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visa färre...
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Karolinska Institutet
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