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  • Jensen, Poul Erik H.Danish Multiple Sclerosis Center, Department of Neurology, Rigshospitalet, University of Copenhagen, Denmar,Univ Copenhagen, Rigshosp, Danish Multiple Sclerosis Ctr, Dept Neurol, Sect 6311, Copenhagen, Denmark. (author)

Detection and kinetics of persistent neutralizing anti-interferon-beta antibodies in patients with multiple sclerosis : Results from the ABIRISK prospective cohort study

  • Article/chapterEnglish2019

Publisher, publication year, extent ...

  • Elsevier,2019
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:his-17654
  • https://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-17654URI
  • https://doi.org/10.1016/j.jneuroim.2018.11.002DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-242973URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:140019699URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • On behalf of the ABIRISK Consortium
  • QC 20190207
  • Two validated assays, a bridging ELISA and a luciferase-based bioassay, were compared for detection of anti-drug antibodies (ADA) against interferon-beta (IFN-β) in patients with multiple sclerosis. Serum samples were tested from patients enrolled in a prospective study of 18 months. In contrast to the ELISA, when IFN-β-specific rabbit polyclonal and human monoclonal antibodies were tested, the bioassay was the more sensitive to detect IFN-β ADA in patients' sera. For clinical samples, selection of method of ELISA should be evaluated prior to the use of a multi-tiered approach. A titer threshold value is reported that may be used as a predictor for persistently positive neutralizing ADA.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Warnke, ClemensDepartment of Neurology, University Hospital Köln, Germany / University of Düsseldorf, Medical Faculty, Department of Neurology, Germany (author)
  • Ingenhoven, KathleenUniversity of Düsseldorf, Medical Faculty, Department of Neurology, Germany (author)
  • Piccoli, LucaUniversità della Svizzera italiana (USI), Faculty of Biomedical Sciences, Institute for Research in Biomedicine, Bellinzona, Switzerland,Departments of Biomedicine and Neurology, University Hospital Basel and University of Basel, Switzerland (author)
  • Gasis, MarciaUniversity of Düsseldorf, Medical Faculty, Department of Neurology, Germany (author)
  • Hermanrud, ChristinaKarolinska Institutet (author)
  • Fernandez-Rodriguez, Blanca M.Università della Svizzera italiana (USI), Faculty of Biomedical Sciences, Institute for Research in Biomedicine, Bellinzona, Switzerland (author)
  • Ryner, MalinDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden (author)
  • Kramer, DanielSanofi-Aventis Germany, Frankfurt Am Main, Germany (author)
  • Link, JennyDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden (author)
  • Ramanujam, RyanKarolinska Institutet,KTH,Matematik (Inst.),Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden / KTH – Royal Institute of Technology, Stockholm, Sweden(Swepub:kth)u112q25k (author)
  • Auer, MichaelInnsbruck Medical University, Innsbruck, Austria (author)
  • Buck, DorotheaDepartment of Neurology, Technische Universität München, Munich, Germany (author)
  • Grummel, VerenaDepartment of Neurology, Technische Universität München, Munich, Germany (author)
  • Bertotti, ElisaMerck NBE Bioanalytics Ivrea, Colleretto Giacosa, Italy (author)
  • Fissolo, NicolasHospital Universitari Vall d'Hebron, Centre d'Esclerosi Múltiple de Catalunya, Barcelona, Spain (author)
  • Oliver-Martos, BegoñaHospital Regional Universitario de Málaga, Instituto de investigación Biomédica de Málaga (IBIMA), Universidad de Málaga, Spain (author)
  • Nytrova, PetraMS Center, Department of Neurology and Center Clinical Neuroscience, Charles University in Prague, 1st Faculty of Medicine and General University Hospital, Prague, Czech Republic (author)
  • Khalil, MichaelDepartment of Neurology, Medical University of Graz, Austria (author)
  • Guger, MichaelClinic for Neurology 2, Kepler University Clinic, Med Campus III, Linz, Austria (author)
  • Rathmaier, SandraClinic for Neurology 2, Kepler University Clinic, Med Campus III, Linz, Austria (author)
  • Sievers-Stober, ClaudiaDepartments of Biomedicine and Neurology, University Hospital Basel and University of Basel, Switzerland (author)
  • Lindberg, Raija L. P.Departments of Biomedicine and Neurology, University Hospital Basel and University of Basel, Switzerland (author)
  • Hässler, SigneCESP, INSERM UMR 1018, Faculty of Medicine, Paris-Sud University, Paris-Saclay, University UVSQ, Villejuif, France (author)
  • Bachelet, DelphineCESP, INSERM UMR 1018, Faculty of Medicine, Paris-Sud University, Paris-Saclay, University UVSQ, Villejuif, France (author)
  • Aktas, OrhanUniversity of Düsseldorf, Medical Faculty, Department of Neurology, Germany (author)
  • Donnellan, NaoimhIpsen Biopharm Ltd., Berkshire, United Kingdom (author)
  • Lawton, AndyGlaxoSmithKline R&D, Uxbridge, Middlesex, United Kingdom (author)
  • Hemmer, BernhardDepartment of Neurology, Technische Universität München, Germany / Munich Cluster for systems Neurology (SyNergy), Germany (author)
  • Havrdova, Eva KubalaMS Center, Department of Neurology and Center Clinical Neuroscience, Charles University in Prague, 1st Faculty of Medicine and General University Hospital, Prague, Czech Republic (author)
  • Kieseier, BerndUniversity of Düsseldorf, Medical Faculty, Department of Neurology, Germany (author)
  • Hartung, Hans-PeterUniversity of Düsseldorf, Medical Faculty, Department of Neurology, Germany (author)
  • Comabella, ManuelHospital Universitari Vall d'Hebron, Centre d'Esclerosi Múltiple de Catalunya, Barcelona, Spain (author)
  • Montalban, XavierHospital Universitari Vall d'Hebron, Centre d'Esclerosi Múltiple de Catalunya, Barcelona, Spain (author)
  • Derfuss, TobiasDepartments of Biomedicine and Neurology, University Hospital Basel and University of Basel, Switzerland (author)
  • Sellebjerg, FinnDanish Multiple Sclerosis Center, Department of Neurology, Rigshospitalet, University of Copenhagen, Denmark (author)
  • Dönnes, PierreSciCross AB, Skövde, Sweden(Swepub:his)donp (author)
  • Pallardy, MarcINSERM UMR 996, Univ. Paris-Sud, Faculty of Pharmacy, Université Paris-Saclay, Châtenay-Malabry, France (author)
  • Spindeldreher, SebastianDrug Metabolism Pharmacokinetics-Biologics, Novartis Institutes for Biomedical Research, Basel, Switzerland (author)
  • Broët, PhilippeCESP, INSERM UMR 1018, Faculty of Medicine, Paris-Sud University, Paris-Saclay, University UVSQ, Villejuif, France / Assistance Publique - Hôpitaux de Paris, Hôpital Paul Brousse, Villejuif, France (author)
  • Deisenhammer, FlorianInnsbruck Medical University, Austria (author)
  • Fogdell-Hahn, AnnaKarolinska Institutet (author)
  • Sorensen, Per SoelbergDanish Multiple Sclerosis Center, Department of Neurology, Rigshospitalet, University of Copenhagen, Denmark,Univ Copenhagen, Rigshosp, Danish Multiple Sclerosis Ctr, Dept Neurol, Sect 6311, Copenhagen, Denmark. (author)
  • Danish Multiple Sclerosis Center, Department of Neurology, Rigshospitalet, University of Copenhagen, DenmarUniv Copenhagen, Rigshosp, Danish Multiple Sclerosis Ctr, Dept Neurol, Sect 6311, Copenhagen, Denmark. (creator_code:org_t)

Related titles

  • In:Journal of Neuroimmunology: Elsevier326, s. 19-270165-57281872-8421

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