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Detection and kinet...
Detection and kinetics of persistent neutralizing anti-interferon-beta antibodies in patients with multiple sclerosis : Results from the ABIRISK prospective cohort study
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- Jensen, Poul Erik H. (author)
- Danish Multiple Sclerosis Center, Department of Neurology, Rigshospitalet, University of Copenhagen, Denmar,Univ Copenhagen, Rigshosp, Danish Multiple Sclerosis Ctr, Dept Neurol, Sect 6311, Copenhagen, Denmark.
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- Warnke, Clemens (author)
- Department of Neurology, University Hospital Köln, Germany / University of Düsseldorf, Medical Faculty, Department of Neurology, Germany
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- Ingenhoven, Kathleen (author)
- University of Düsseldorf, Medical Faculty, Department of Neurology, Germany
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- Piccoli, Luca (author)
- Università della Svizzera italiana (USI), Faculty of Biomedical Sciences, Institute for Research in Biomedicine, Bellinzona, Switzerland,Departments of Biomedicine and Neurology, University Hospital Basel and University of Basel, Switzerland
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- Gasis, Marcia (author)
- University of Düsseldorf, Medical Faculty, Department of Neurology, Germany
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- Hermanrud, Christina (author)
- Karolinska Institutet
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- Fernandez-Rodriguez, Blanca M. (author)
- Università della Svizzera italiana (USI), Faculty of Biomedical Sciences, Institute for Research in Biomedicine, Bellinzona, Switzerland
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- Ryner, Malin (author)
- Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
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- Kramer, Daniel (author)
- Sanofi-Aventis Germany, Frankfurt Am Main, Germany
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- Link, Jenny (author)
- Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
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- Ramanujam, Ryan (author)
- Karolinska Institutet,KTH,Matematik (Inst.),Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden / KTH – Royal Institute of Technology, Stockholm, Sweden
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- Auer, Michael (author)
- Innsbruck Medical University, Innsbruck, Austria
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- Buck, Dorothea (author)
- Department of Neurology, Technische Universität München, Munich, Germany
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- Grummel, Verena (author)
- Department of Neurology, Technische Universität München, Munich, Germany
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- Bertotti, Elisa (author)
- Merck NBE Bioanalytics Ivrea, Colleretto Giacosa, Italy
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- Fissolo, Nicolas (author)
- Hospital Universitari Vall d'Hebron, Centre d'Esclerosi Múltiple de Catalunya, Barcelona, Spain
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- Oliver-Martos, Begoña (author)
- Hospital Regional Universitario de Málaga, Instituto de investigación Biomédica de Málaga (IBIMA), Universidad de Málaga, Spain
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- Nytrova, Petra (author)
- MS Center, Department of Neurology and Center Clinical Neuroscience, Charles University in Prague, 1st Faculty of Medicine and General University Hospital, Prague, Czech Republic
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- Khalil, Michael (author)
- Department of Neurology, Medical University of Graz, Austria
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- Guger, Michael (author)
- Clinic for Neurology 2, Kepler University Clinic, Med Campus III, Linz, Austria
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- Rathmaier, Sandra (author)
- Clinic for Neurology 2, Kepler University Clinic, Med Campus III, Linz, Austria
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- Sievers-Stober, Claudia (author)
- Departments of Biomedicine and Neurology, University Hospital Basel and University of Basel, Switzerland
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- Lindberg, Raija L. P. (author)
- Departments of Biomedicine and Neurology, University Hospital Basel and University of Basel, Switzerland
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- Hässler, Signe (author)
- CESP, INSERM UMR 1018, Faculty of Medicine, Paris-Sud University, Paris-Saclay, University UVSQ, Villejuif, France
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- Bachelet, Delphine (author)
- CESP, INSERM UMR 1018, Faculty of Medicine, Paris-Sud University, Paris-Saclay, University UVSQ, Villejuif, France
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- Aktas, Orhan (author)
- University of Düsseldorf, Medical Faculty, Department of Neurology, Germany
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- Donnellan, Naoimh (author)
- Ipsen Biopharm Ltd., Berkshire, United Kingdom
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- Lawton, Andy (author)
- GlaxoSmithKline R&D, Uxbridge, Middlesex, United Kingdom
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- Hemmer, Bernhard (author)
- Department of Neurology, Technische Universität München, Germany / Munich Cluster for systems Neurology (SyNergy), Germany
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- Havrdova, Eva Kubala (author)
- MS Center, Department of Neurology and Center Clinical Neuroscience, Charles University in Prague, 1st Faculty of Medicine and General University Hospital, Prague, Czech Republic
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- Kieseier, Bernd (author)
- University of Düsseldorf, Medical Faculty, Department of Neurology, Germany
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- Hartung, Hans-Peter (author)
- University of Düsseldorf, Medical Faculty, Department of Neurology, Germany
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- Comabella, Manuel (author)
- Hospital Universitari Vall d'Hebron, Centre d'Esclerosi Múltiple de Catalunya, Barcelona, Spain
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- Montalban, Xavier (author)
- Hospital Universitari Vall d'Hebron, Centre d'Esclerosi Múltiple de Catalunya, Barcelona, Spain
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- Derfuss, Tobias (author)
- Departments of Biomedicine and Neurology, University Hospital Basel and University of Basel, Switzerland
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- Sellebjerg, Finn (author)
- Danish Multiple Sclerosis Center, Department of Neurology, Rigshospitalet, University of Copenhagen, Denmark
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- Dönnes, Pierre (author)
- SciCross AB, Skövde, Sweden
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- Pallardy, Marc (author)
- INSERM UMR 996, Univ. Paris-Sud, Faculty of Pharmacy, Université Paris-Saclay, Châtenay-Malabry, France
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- Spindeldreher, Sebastian (author)
- Drug Metabolism Pharmacokinetics-Biologics, Novartis Institutes for Biomedical Research, Basel, Switzerland
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- Broët, Philippe (author)
- CESP, INSERM UMR 1018, Faculty of Medicine, Paris-Sud University, Paris-Saclay, University UVSQ, Villejuif, France / Assistance Publique - Hôpitaux de Paris, Hôpital Paul Brousse, Villejuif, France
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- Deisenhammer, Florian (author)
- Innsbruck Medical University, Austria
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- Fogdell-Hahn, Anna (author)
- Karolinska Institutet
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- Sorensen, Per Soelberg (author)
- Danish Multiple Sclerosis Center, Department of Neurology, Rigshospitalet, University of Copenhagen, Denmark,Univ Copenhagen, Rigshosp, Danish Multiple Sclerosis Ctr, Dept Neurol, Sect 6311, Copenhagen, Denmark.
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Danish Multiple Sclerosis Center, Department of Neurology, Rigshospitalet, University of Copenhagen, Denmar Univ Copenhagen, Rigshosp, Danish Multiple Sclerosis Ctr, Dept Neurol, Sect 6311, Copenhagen, Denmark (creator_code:org_t)
- Elsevier, 2019
- 2019
- English.
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In: Journal of Neuroimmunology. - : Elsevier. - 0165-5728 .- 1872-8421. ; 326, s. 19-27
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Two validated assays, a bridging ELISA and a luciferase-based bioassay, were compared for detection of anti-drug antibodies (ADA) against interferon-beta (IFN-β) in patients with multiple sclerosis. Serum samples were tested from patients enrolled in a prospective study of 18 months. In contrast to the ELISA, when IFN-β-specific rabbit polyclonal and human monoclonal antibodies were tested, the bioassay was the more sensitive to detect IFN-β ADA in patients' sera. For clinical samples, selection of method of ELISA should be evaluated prior to the use of a multi-tiered approach. A titer threshold value is reported that may be used as a predictor for persistently positive neutralizing ADA.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Anti-drug antibodies
- Bridging ELISA
- Interferon-beta
- Luciferase-based bioassay
- Multiple sclerosis
- Neutralizing antibodies
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Jensen, Poul Eri ...
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Warnke, Clemens
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Ingenhoven, Kath ...
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Piccoli, Luca
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Gasis, Marcia
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Hermanrud, Chris ...
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show more...
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Fernandez-Rodrig ...
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Ryner, Malin
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Kramer, Daniel
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Link, Jenny
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Ramanujam, Ryan
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Auer, Michael
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Buck, Dorothea
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Grummel, Verena
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Bertotti, Elisa
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Fissolo, Nicolas
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Oliver-Martos, B ...
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Nytrova, Petra
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Khalil, Michael
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Guger, Michael
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Rathmaier, Sandr ...
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Sievers-Stober, ...
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Lindberg, Raija ...
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Hässler, Signe
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Bachelet, Delphi ...
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Aktas, Orhan
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Donnellan, Naoim ...
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Lawton, Andy
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Hemmer, Bernhard
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Havrdova, Eva Ku ...
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Kieseier, Bernd
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Hartung, Hans-Pe ...
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Comabella, Manue ...
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Montalban, Xavie ...
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Derfuss, Tobias
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Sellebjerg, Finn
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Dönnes, Pierre
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Pallardy, Marc
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Spindeldreher, S ...
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Broët, Philippe
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Deisenhammer, Fl ...
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Fogdell-Hahn, An ...
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Sorensen, Per So ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Journal of Neuro ...
- By the university
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University of Skövde
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Royal Institute of Technology
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Karolinska Institutet