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The influence of de...
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Kallioinen, MinnaDepartment of Perioperative Services, Intensive Care and Pain Medicine, Turku University Hospital, Finland
(författare)
The influence of dexmedetomidine and propofol on circulating cytokine levels in healthy subjects
- Artikel/kapitelEngelska2019
Förlag, utgivningsår, omfång ...
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2019-12-05
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BioMed Central,2019
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:his-18204
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https://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-18204URI
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https://doi.org/10.1186/s12871-019-0895-3DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Background: Surgery and diseases modify inflammatory responses and the immune system. Anesthetic agents also have effects on the human immune system but the responses they induce may be altered or masked by the surgical procedures or underlying illnesses. The aim of this study was to assess how single-drug dexmedetomidine and propofol anesthesia without any surgical intervention alter acute immunological biomarkers in healthy subjects. Methods: Thirty-five healthy, young male subjects were anesthetized using increasing concentrations of dexmedetomidine (n = 18) or propofol (n = 17) until loss of responsiveness (LOR) was detected. The treatment allocation was randomized. Multi-parametric immunoassays for the detection of 48 cytokines, chemokines and growth factors were used. Concentrations were determined at baseline and at the highest drug concentration for each subject. Results: The changes in the concentration of eotaxin (decrease after dexmedetomidine) and platelet-derived growth factor (PDGF, increase after propofol) were statistically significantly different between the groups. Significant changes were detected within both groups; the concentrations of monocyte chemotactic protein 1, chemokine ligand 27 and macrophage migration inhibitory factor were lower in both groups after the drug administration. Dexmedetomidine decreased the concentration of eotaxin, interleukin-18, interleukin-2Ra, stem cell factor, stem cell growth factor and vascular endothelial growth factor, and propofol decreased significantly the levels of hepatocyte growth factor, IFN-.-induced protein 10 and monokine induced by IFN-gamma, and increased the levels of interleukin-17, interleukin-5, interleukin-7 and PDGF. Conclusions: Dexmedetomidine seemed to have an immunosuppressive effect on the immune system whereas propofol seemed to induce mixed pro- and anti-inflammatory effects on the immune system. The choice of anesthetic agent could be relevant when treating patients with compromised immunological defense mechanisms. Trial registration: Before subject enrollment, the study was registered in the European Clinical Trials database (EudraCT number 2013-001496-21, The Neural Mechanisms of Anesthesia and Human Consciousness) and in ClinicalTrials.gov (Principal Investigator: Harry Scheinin, number NCT01889004, The Neural Mechanisms of Anesthesia and Human Consciousness, Part 2, on the 23rd of June 2013).
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Scheinin, AnnalottaDepartment of Perioperative Services, Intensive Care and Pain Medicine, Turku University Hospital, Finland / Turku PET Centre, University of Turku and Turku University Hospital, Finland
(författare)
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Maksimow, MikaelMedicity Research Laboratory, University of Turku, Finland
(författare)
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Långsjö, JaakkoTurku PET Centre, University of Turku and Turku University Hospital, Finland / Department of Intensive Care, Tampere University Hospital, Finland
(författare)
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Kaisti, KaikeTurku PET Centre, University of Turku and Turku University Hospital, Finland / Department of Anesthesiology and Intensive Care, Oulu University Hospital, Finland
(författare)
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Takala, RiikkaDepartment of Perioperative Services, Intensive Care and Pain Medicine, Turku University Hospital, Finland
(författare)
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Vahlberg, TeroDepartment of Clinical Medicine, Biostatistics, University of Turku and Turku University Hospital, Finland
(författare)
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Valli, Katja,1973-Högskolan i Skövde,Institutionen för biovetenskap,Forskningsmiljön Systembiologi,Department of Psychology and Speech-Language Pathology, and Turku Brain and Mind Centre, University of Turku, Finland,Kognitiv neurovetenskap och filosofi, Consciousness and Cognitive Neuroscience(Swepub:his)vala
(författare)
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Salmi, MarkoMedicity Research Laboratory, University of Turku, Finland / Institute of Biomedicine, University of Turku, Finland
(författare)
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Scheinin, HarryDepartment of Perioperative Services, Intensive Care and Pain Medicine, Turku University Hospital, Finland / Turku PET Centre, University of Turku and Turku University Hospital, Finland / Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku, Finland
(författare)
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Maksimow, AnuDepartment of Perioperative Services, Intensive Care and Pain Medicine, Turku University Hospital, Finland
(författare)
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Department of Perioperative Services, Intensive Care and Pain Medicine, Turku University Hospital, FinlandDepartment of Perioperative Services, Intensive Care and Pain Medicine, Turku University Hospital, Finland / Turku PET Centre, University of Turku and Turku University Hospital, Finland
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:BMC Anesthesiology: BioMed Central19:1, s. 1-81471-22531471-2253
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Kallioinen, Minn ...
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Scheinin, Annalo ...
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Maksimow, Mikael
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Långsjö, Jaakko
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Kaisti, Kaike
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Takala, Riikka
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Vahlberg, Tero
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Valli, Katja, 19 ...
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Salmi, Marko
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Scheinin, Harry
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Maksimow, Anu
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