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Modeling the regula...
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Karlsson, DianaHögskolan i Skövde,Institutionen för vård och natur
(author)
Modeling the regulation of the competence-evoking quorum sensing network in Streptococcus pneumoniae
- Article/chapterEnglish2007
Publisher, publication year, extent ...
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Elsevier,2007
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:his-1887
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https://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-1887URI
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https://doi.org/10.1016/j.biosystems.2006.08.005DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:115708284URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Competence for genetic transformation seems to play a fundamental role in the biology of Streptococcus pneumoniae and is believed to account for serotype switching, evolution of virulence factors, and rapid emergence of antibiotic resistance. The initiation of competence is regulated by the quorum sensing system referred as the ComABCDE pathway. Experimental studies reveal that competence is down-regulated a short time after its induction and several hypotheses about the mechanism(s) responsible for this shut-down have been presented. Possibly, a ComX-dependent gene product, such as a repressor or a phosphatase, is involved. To better understand the down-regulation of the competence-evoking system in S. pneumoniae, a mathematical model was set up. By analyzing the model, we suggest that shut-down of competence possibly occurs at the transcriptional level on the comCDE operon. As a result of introducing a putative comX-dependent repressor, which inhibits expression of comCDE and comX, in the mathematical model, competence is demonstrated to appear in waves. This is supported by experimental studies showing the appearance of successive competence cycles in pneumococcal batch cultures.
Added entries (persons, corporate bodies, meetings, titles ...)
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Karlsson, StefanHögskolan i Skövde,Institutionen för vård och natur(Swepub:his)kale
(author)
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Gustafsson, ErikHögskolan i Skövde,Institutionen för vård och natur(Swepub:his)guse
(author)
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Henriques Normark, BirgittaKarolinska Institutet
(author)
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Nilsson, PatricHögskolan i Skövde,Institutionen för vård och natur(Swepub:his)nisp
(author)
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Högskolan i SkövdeInstitutionen för vård och natur
(creator_code:org_t)
Related titles
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In:Biosystems (Amsterdam. Print): Elsevier90:1, s. 211-2230303-26471872-8324
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