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  • Kallionpää, Roosa E.Department of Psychology and Speech-Language Pathology, and Turku Brain and Mind Center, University of Turku, Finland / Department of Perioperative Services, Intensive Care and Pain Medicine, Turku University Hospital, Finland (författare)

Alpha band frontal connectivity is a state-specific electroencephalographic correlate of unresponsiveness during exposure to dexmedetomidine and propofol

  • Artikel/kapitelEngelska2020

Förlag, utgivningsår, omfång ...

  • Elsevier,2020
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:his-18928
  • https://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-18928URI
  • https://doi.org/10.1016/j.bja.2020.05.068DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • CC BY-NC-ND. 4.0
  • Background herent alpha electroencephalogram (EEG) rhythms in the frontal cortex have been correlated with the hypnotic effects of propofol and dexmedetomidine, but less is known about frontal connectivity as a state-specific correlate of unresponsiveness as compared with long-range connectivity. We aimed to distinguish dose- and state-dependent effects of dexmedetomidine and propofol on EEG connectivity. thods rty-seven healthy males received either dexmedetomidine (n=23) or propofol (n=24) as target-controlled infusion with stepwise increments until loss of responsiveness (LOR). We attempted to arouse participants during constant dosing (return of responsiveness [ROR]), and the target concentration was then increased 50% to achieve presumed loss of consciousness. We collected 64-channel EEG data and prefrontal–frontal and anterior–posterior functional connectivity in the alpha band (8–14 Hz) was measured using coherence and weighted phase lag index (wPLI). Directed connectivity was measured with directed phase lag index (dPLI). sults efrontal–frontal EEG-based connectivity discriminated the states at the different drug concentrations. At ROR, prefrontal–frontal connectivity reversed to the level observed before LOR, indicating that connectivity changes were related to unresponsiveness rather than drug concentration. Unresponsiveness was associated with emergence of frontal-to-prefrontal dominance (dPLI: –0.13 to –0.40) in contrast to baseline (dPLI: 0.01–0.02). Coherence, wPLI, and dPLI had similar capability to discriminate the states that differed in terms of responsiveness and drug concentration. In contrast, anterior–posterior connectivity in the alpha band did not differentiate LOR and ROR. nclusions cal prefrontal–frontal EEG-based connectivity reflects unresponsiveness induced by propofol or dexmedetomidine, suggesting its utility in monitoring the anaesthetised state with these agents. inical trial registration

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Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Valli, KatjaHögskolan i Skövde,Institutionen för biovetenskap,Forskningsmiljön Systembiologi,Department of Psychology and Speech-Language Pathology, and Turku Brain and Mind Center, University of Turku, Finland / Department of Perioperative Services, Intensive Care and Pain Medicine, Turku University Hospital, Finland,Kognitiv neurovetenskap och filosofi, Consciousness and Cognitive Neuroscience(Swepub:his)vala (författare)
  • Scheinin, AnnalottaDepartment of Perioperative Services, Intensive Care and Pain Medicine, Turku University Hospital, Finland / Turku PET Centre, University of Turku and Turku University Hospital, Finland (författare)
  • Långsjö, JaakkoDepartment of Intensive Care, Tampere University Hospital, Finland (författare)
  • Maksimow, AnuDepartment of Perioperative Services, Intensive Care and Pain Medicine, Turku University Hospital, Finland (författare)
  • Vahlberg, TeroDepartment of Clinical Medicine, Biostatistics, University of Turku and Turku University Hospital, Finland (författare)
  • Revonsuo, AnttiHögskolan i Skövde,Institutionen för biovetenskap,Forskningsmiljön Systembiologi,Department of Psychology and Speech-Language Pathology, and Turku Brain and Mind Center, University of Turku, Finland,Kognitiv neurovetenskap och filosofi, Consciousness and Cognitive Neuroscience(Swepub:his)reva (författare)
  • Scheinin, HarryDepartment of Perioperative Services, Intensive Care and Pain Medicine, Turku University Hospital, Finland / Turku PET Centre, University of Turku and Turku University Hospital, Finland / Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku, Finland (författare)
  • Mashour, George A.Department of Anesthesiology, Center for Consciousness Science, University of Michigan Medical School, Ann Arbor, MI, USA (författare)
  • Li, DuanDepartment of Anesthesiology, Center for Consciousness Science, University of Michigan Medical School, Ann Arbor, MI, USA (författare)
  • Department of Psychology and Speech-Language Pathology, and Turku Brain and Mind Center, University of Turku, Finland / Department of Perioperative Services, Intensive Care and Pain Medicine, Turku University Hospital, FinlandInstitutionen för biovetenskap (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:British Journal of Anaesthesia: Elsevier125:4, s. 518-5280007-09121471-6771

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