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  • González-Gil, Esther M.Department of Biochemistry and Molecular Biology II, Instituto de Nutrición y Tecnología de los Alimentos, Center of Biomedical Research (CIBM), Universidad de Granada, Spain ; GENUD (Growth, Exercise, Nutrition and Development) Research Group, University of Zaragoza, Spain ; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III, Madrid, Spain (författare)

Improving cardiorespiratory fitness protects against inflammation in children : the IDEFICS study

  • Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

  • 2021-04-09
  • Springer Nature,2022
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:his-19650
  • https://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-19650URI
  • https://doi.org/10.1038/s41390-021-01471-0DOI
  • https://gup.ub.gu.se/publication/303337URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • © 2021, The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc.Published online: 9 April 2021
  • Background: Muscular and cardiorespiratory fitness (MF and CRF) have been related to inflammation. Thus, the aim of this study was to assess the relationship between fitness and high-sensitivity C-reactive protein (hs-CRP) in European children both in the cross-sectional and longitudinal analysis. Methods: Three hundred and fifty-seven children (46.2% males) aged 2–9 years with hs-CRP measured, data from MF and CRF, diet quality, objectively measured physical activity (PA) and screen time at baseline and follow-up after 2 years were included. Body mass index z-score (zBMI), waist circumference (WC) and fat mass index (FMI) were assessed. MF and CRF were also dichotomized as follows: low-medium quartiles (Q1–Q3) and highest quartile (Q4). Results: At follow-up, children with the highest CRF (Q4) showed a lower probability of having high hs-CRP. In the longitudinal analysis, children who improved their CRF over time showed a significantly lower probability (p < 0.05) of being in the highest hs-CRP category at follow-up, independently of the body composition index considered: odds ratio (OR) = 0.22 for zBMI, OR = 0.17 for WC, and OR = 0.21 for FMI. Conclusions: Improving CRF during childhood reduces the odds of an inflammatory profile, independently of body composition and lifestyle behaviours. These highlight the importance of enhancing fitness, especially CRF, to avoid an inflammatory state in children. Impact: Improvements in the cardiorespiratory profile during childhood could reverse an unfavourable inflammatory status.There is a longitudinal and inverse association between CRF and inflammation in children.This is the first longitudinal study assessing the relationship between fitness and inflammation during childhood that takes also into account the lifestyle behaviours.Results from the present study suggest a protective role of fitness already in childhood.Efforts to improve fitness in children should be aimed at as inflammation could trigger future cardiovascular disease. 

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Santaliestra-Pasías, Alba M.GENUD (Growth, Exercise, Nutrition and Development) Research Group, University of Zaragoza, Zaragoza, Spain ; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III, Madrid, Spain ; Instituto Agroalimentario de Aragón (IA2), Zaragoza, Spain ; Instituto de Investigación Sanitaria Aragón (IIS Aragón), Zaragoza, Spain (författare)
  • Buck, ChristophLeibniz Institute for Prevention Research and Epidemiology—BIPS, Bremen, Germany (författare)
  • Gracia-Marco, LuisGENUD (Growth, Exercise, Nutrition and Development) Research Group, University of Zaragoza, Zaragoza, Spain ; PROFITH (PROmoting FITness and Health through physical activity) Research Group, Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Spain (författare)
  • Lauria, FabioInstitute of Food Sciences, National Research Council, Avellino, Italy (författare)
  • Pala, ValeriaEpidemiology and Prevention Unit, Fondazione IRCCS—Istituto Nazionale dei Tumori, Milan, Italy (författare)
  • Molnar, DenesDepartment of Pediatrics, Medical School, University of Pécs, Hungary (författare)
  • Veidebaum, ToomasNational Institute for Health Development, Center of Health and Behavioral Science, Tallinn, Estonia (författare)
  • Iacoviello, LiciaDepartment of Epidemiology and Prevention, IRCCS Istituto Neurologico Mediterraneo Neuromed, Pozzilli, Italy ; Department of Medicine and Surgery, Research Center in Epidemiology and Preventive Medicine (EPIMED), University of Insubria, Varese, Italy (författare)
  • Tornaritis, MichaelResearch and Education Institute of Child Health, Strovolos, Cyprus (författare)
  • Eiben, GabrieleHögskolan i Skövde,Institutionen för hälsovetenskaper,Forskningsmiljön hälsa, hållbarhet och digitalisering,Medborgarcentrerad hälsa MeCH, Research on Citizen Centered Health, University of Skövde (Reacch US)(Swepub:his)eibg (författare)
  • Lissner, Lauren,1956Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine(Swepub:gu)xlisla (författare)
  • Schwarz, HeikeLeibniz Institute for Prevention Research and Epidemiology—BIPS, Bremen, Germany (författare)
  • Ahrens, WolfgangLeibniz Institute for Prevention Research and Epidemiology—BIPS, Bremen, Germany ; Institute of Statistics, Bremen University, Germany (författare)
  • De Henauw, StefaanDepartment of Public Health and Primary Care, Faculty of Medicine and Health Sciences, Ghent University, Belgium (författare)
  • Fraterman, ArnoLaboratoriumsmedizin Dortmund, Eberhard & Partner, Dortmund, Germany (författare)
  • Moreno, Luis A.GENUD (Growth, Exercise, Nutrition and Development) Research Group, University of Zaragoza, Zaragoza, Spain ; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III, Madrid, Spain ; Instituto Agroalimentario de Aragón (IA2), Zaragoza, Spain ; Instituto de Investigación Sanitaria Aragón (IIS Aragón), Zaragoza, Spain (författare)
  • Department of Biochemistry and Molecular Biology II, Instituto de Nutrición y Tecnología de los Alimentos, Center of Biomedical Research (CIBM), Universidad de Granada, Spain ; GENUD (Growth, Exercise, Nutrition and Development) Research Group, University of Zaragoza, Spain ; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III, Madrid, SpainGENUD (Growth, Exercise, Nutrition and Development) Research Group, University of Zaragoza, Zaragoza, Spain ; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III, Madrid, Spain ; Instituto Agroalimentario de Aragón (IA2), Zaragoza, Spain ; Instituto de Investigación Sanitaria Aragón (IIS Aragón), Zaragoza, Spain (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Pediatric Research: Springer Nature91:3, s. 681-6890031-39981530-0447

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