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- Diaz Cruz, Maria AraceliJönköping University,HHJ. Biomedicinsk plattform,Research School of Health and Welfare, School of Health and Welfare, Jönköping University, Sweden (author)
Cis-regulatory elements in conserved non-coding sequences of nuclear receptor genes indicate for crosstalk between endocrine systems
- Article/chapterEnglish2021
Publisher, publication year, extent ...
- 2021-04-12
- De Gruyter Open,2021
- electronicrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:his-19687
- https://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-19687URI
- https://doi.org/10.1515/med-2021-0264DOI
- https://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-52373URI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
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Notes
- CC BY 4.0© 2021 Maria Araceli Diaz Cruz et al., published by De Gruyter 2021.Corresponding author: Maria Araceli Diaz Cruz, Research School of Health and Welfare, School of Health and Welfare, Jönköping University, Jönköping, Sweden, e-mail: Maria-Araceli.Cruz@ju.se, tel: +46-737553177This study was financially supported by Högskolans Jubileumsfond at the University College of Skövde (Dnr HS 2015/536). Jönköping University provided with open access funding and the necessary resources to carry out this investigation.
- Nuclear receptors (NRs) are ligand-activated transcription factors that regulate gene expression when bound to specific DNA sequences. Crosstalk between steroid NR systems has been studied for understanding the development of hormone-driven cancers but not to an extent at a genetic level. This study aimed to investigate crosstalk between steroid NRs in conserved intron and exon sequences, with a focus on steroid NRs involved in prostate cancer etiology. For this purpose, we evaluated conserved intron and exon sequences among all 49 members of the NR Superfamily (NRS) and their relevance as regulatory sequences and NR-binding sequences. Sequence conservation was found to be higher in the first intron (35%), when compared with downstream introns. Seventy-nine percent of the conserved regions in the NRS contained putative transcription factor binding sites (TFBS) and a large fraction of these sequences contained splicing sites (SS). Analysis of transcription factors binding to putative intronic and exonic TFBS revealed that 5 and 16%, respectively, were NRs. The present study suggests crosstalk between steroid NRs, e.g., vitamin D, estrogen, progesterone, and retinoic acid endocrine systems, through cis-regulatory elements in conserved sequences of introns and exons. This investigation gives evidence for crosstalk between steroid hormones and contributes to novel targets for steroid NR regulation.
Subject headings and genre
- NATURVETENSKAP Biologi Biokemi och molekylärbiologi hsv//swe
- NATURAL SCIENCES Biological Sciences Biochemistry and Molecular Biology hsv//eng
- conserved sequences
- crosstalk
- nuclear receptor binding domains
- splicing sites
- transcription factor binding sites
- Translationell medicin TRIM
- Translational Medicine TRIM
Added entries (persons, corporate bodies, meetings, titles ...)
- Lund, DanJönköping University,HHJ, Avdelningen för naturvetenskap och biomedicin,HHJ. Biomedicinsk plattform,Department of Natural Science and Biomedicine, School of Health and Welfare, Jönköping University, Sweden(Swepub:hj)lundda (author)
- Szekeres, FerencHögskolan i Skövde,Institutionen för hälsovetenskaper,Forskningsmiljön hälsa, hållbarhet och digitalisering,Translationell medicin TRIM, Translational Medicine,Department of Biomedicine, School of Health Sciences, University of Skövde, Skövde, Sweden(Swepub:his)szef (author)
- Karlsson, SandraJönköping University,HHJ, Avdelningen för naturvetenskap och biomedicin,HHJ. Biomedicinsk plattform,Department of Natural Science and Biomedicine, School of Health and Welfare, Jönköping University, Sweden(Swepub:hj)karsan (author)
- Faresjö, MariaJönköping University,HHJ, Avdelningen för naturvetenskap och biomedicin,HHJ. Biomedicinsk plattform,HHJ. CHILD,Department of Natural Science and Biomedicine, School of Health and Welfare, Jönköping University, Sweden(Swepub:hj)farm (author)
- Larsson, DennisSahlgrenska University Hospital, Gothia Forum for Clinical Research, Gothenburg, Sweden(Swepub:his)lars (author)
- Jönköping UniversityHHJ. Biomedicinsk plattform (creator_code:org_t)
Related titles
- In:Open Medicine (Poland): De Gruyter Open16:1, s. 640-6502391-5463
Internet link
- https://doi.org/10.1515/med-2021-0264Fulltext
- https://his.diva-portal.org/smash/get/diva2:1552662/FULLTEXT01.pdffulltext:print
- https://www.degruyter.com/document/doi/10.1515/med-2021-0264/pdf
- https://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-19687
- https://doi.org/10.1515/med-2021-0264
- https://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-52373
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