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AMNE:(MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Immunologi inom det medicinska området)
Sökning: AMNE:(MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Immunologi inom det medicinska området) > Jönköping University > Salomonsson Kent > Serum amyloid A – A...
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- Bengnér, JohannesPaediatric Clinic, Ryhov County Hospital, Jönköping, Region Jönköping County, Sweden,Länssjukhuset Ryhov,County Hospital Ryhov (författare)
Serum amyloid A – A prime candidate for identification of neonatal sepsis
- Artikel/kapitelEngelska2021
Förlag, utgivningsår, omfång ...
- Elsevier,2021
- printrdacarrier
Nummerbeteckningar
- LIBRIS-ID:oai:DiVA.org:his-20241
- https://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-20241URI
- https://doi.org/10.1016/j.clim.2021.108787DOI
- https://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-54114URI
- https://research.chalmers.se/publication/524875URI
Kompletterande språkuppgifter
- Språk:engelska
- Sammanfattning på:engelska
Ingår i deldatabas
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Klassifikation
Anmärkningar
- Neonatal sepsis is common, lethal, and hard to diagnose. In combination with clinical findings and blood culture, biomarkers are crucial to make the correct diagnose. A Swedish national inquiry indicated that neonatologists were not quite satisfied with the available biomarkers. We assessed the kinetics of 15 biomarkers simultaneously: ferritin, fibrinogen, granulocyte colony-stimulating factor (G-CSF), interferon (IFN)-γ, interleukin (IL)-1β, −6, −8, −10, macrophage inflammatory protein (MIP)-1β, procalcitonin, resistin, serum amyloid A (SAA), tumor necrosis factor (TNF)-α, tissue plasminogen activator-3 and visfatin. The goal was to observe how quickly they rise in response to infection, and for how long they remain elevated. From a neonatal intensive care unit, newborns ≥28 weeks gestational age were recruited. Sixty-eight newborns were recruited to the study group (SG), and fifty-one to the control group (CG). The study group subjects were divided into three subgroups depending on clinical findings: confirmed sepsis (CSG), suspected sepsis (SSG) and no sepsis. CSG and SSG were also merged into an entire sepsis group (ESG) for sub-analysis. Blood samples were collected at three time-points; 0 h, 12–24 h and 48–72 h, in order to mimic a “clinical setting”. At 0 h, visfatin was elevated in SSG compared to CG; G-CSF, IFN-γ, IL-1β, −8 and − 10 were elevated in SSG and ESG compared to CG, whereas IL-6 and SAA were elevated in all groups compared to CG. At 12–24 h, IL-8 was elevated in ESG compared to CG, visfatin was elevated in ESG and SSG compared to CG, and SAA was elevated in all three groups compared to CG. At 48–72 h, fibrinogen was elevated in ESG compared to CG, IFN-γ and IL-1β were elevated in SSG and ESG compared to CG, whereas IL-8 and SAA were elevated in all three groups compared to CG. A function of time-formula is introduced as a tool for theoretical prediction of biomarker levels at any time-point. We conclude that SAA has the most favorable kinetics regarding diagnosing neonatal sepsis, of the biomarkers studied. It is also readily available methodologically, making it a prime candidate for clinical use.
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Infektionsmedicin hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Infectious Medicine hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Immunologi inom det medicinska området hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Immunology in the medical area hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Pediatrik hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Pediatrics hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Klinisk laboratoriemedicin hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Clinical Laboratory Medicine hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Medicinsk bioteknologi Biomedicinsk laboratorievetenskap/teknologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Medical Biotechnology Biomedical Laboratory Science/Technology hsv//eng
- Biomarkers
- Function of time
- Kinetics
- Neonatal
- Sepsis
- Serum amyloid A
- Virtual Manufacturing Processes
- Virtual Manufacturing Processes
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Quttineh, MaysaeDepartment of Laboratory Medicine, Jönköping, Region Jönköping County, Sweden,Region Jönköpings län (författare)
- Gäddlin, Per-OlofPaediatric Clinic, Ryhov County Hospital, Jönköping, Region Jönköping County, Sweden,Länssjukhuset Ryhov,County Hospital Ryhov (författare)
- Salomonsson, KentHögskolan i Skövde,Institutionen för ingenjörsvetenskap,Forskningsmiljön Virtuell produkt- och produktionsutveckling,Virtual Manufacturing Processes,Virtual Engineering Research Environment, School of Engineering Science, University of Skövde, Skövde, Sweden,University of Skövde(Swepub:hj)salken (författare)
- Faresjö, MariaJönköping University,HHJ, Avdelningen för klinisk diagnostik,HHJ. Biomedicinsk plattform,Biomedical Platform, Department of Natural Science and Biomedicine, School of Health and Welfare, Jönköping University, Sweden ; Department of Biology and Biological Engineering, Chalmers University of Technology, Göteborg, Sweden,Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)faresjo (författare)
- Paediatric Clinic, Ryhov County Hospital, Jönköping, Region Jönköping County, SwedenLänssjukhuset Ryhov (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Clinical Immunology: Elsevier229:1087871521-66161521-7035
Internetlänk
- https://doi.org/10.1016/j.clim.2021.108787
- https://doi.org/10.1016/j.clim.2021.108787Fulltext
- https://research.chalmers.se/publication/524875/file/524875_Fulltext.pdfFULLTEXT
- https://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-20241
- https://doi.org/10.1016/j.clim.2021.108787
- https://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-54114
- https://research.chalmers.se/publication/524875
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