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On no man's land :
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Radek, LindaTurku PET Centre, Turku University Hospital and University of Turku, Finland
(författare)
On no man's land : Subjective experiences during unresponsive and responsive sedative states induced by four different anesthetic agents
- Artikel/kapitelEngelska2021
Förlag, utgivningsår, omfång ...
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Elsevier,2021
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:his-20716
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https://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-20716URI
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https://doi.org/10.1016/j.concog.2021.103239DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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CC BY 4.0© 2021 The AuthorsCorresponding author. E-mail address: liemra@utu.fi (L. Radek).
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To understand how anesthetics with different molecular mechanisms affect consciousness, we explored subjective experiences recalled after responsive and unresponsive sedation induced with equisedative doses of dexmedetomidine, propofol, sevoflurane, and S-ketamine in healthy male participants (N = 140). The anesthetics were administered in experimental setting using target-controlled infusion or vapouriser for one hour. Interviews conducted after anesthetic administration revealed that 46.9% (n = 46) of arousable participants (n = 98) reported experiences, most frequently dreaming or memory incorporation of the setting. Participants receiving dexmedetomidine reported experiences most often while S-ketamine induced the most multimodal experiences. Responsiveness at the end of anesthetic administration did not affect the prevalence or content of reported experiences. These results demonstrate that subjective experiences during responsive and unresponsive sedation are common and anesthetic agents with different molecular mechanisms of action may have different effects on the prevalence and complexity of the experiences, albeit in the present sample the differences between drugs were minute.
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Koskinen, LauriDepartment of Psychology and Speech-Language Pathology, and Turku Brain and Mind Center, University of Turku, Finland
(författare)
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Sandman, NilsDepartment of Psychology and Speech-Language Pathology, and Turku Brain and Mind Center, University of Turku, Finland
(författare)
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Laaksonen, LauriTurku PET Centre, Turku University Hospital and University of Turku, Finland ; Department of Perioperative Services, Intensive Care and Pain Medicine, Turku University Hospital and University of Turku, Finland
(författare)
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Kallionpää, Roosa E.Department of Psychology and Speech-Language Pathology, and Turku Brain and Mind Center, University of Turku, Finland
(författare)
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Scheinin, AnnalottaTurku PET Centre, Turku University Hospital and University of Turku, Finland ; Department of Perioperative Services, Intensive Care and Pain Medicine, Turku University Hospital and University of Turku, Finland
(författare)
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Rajala, VilleDepartment of Perioperative Services, Intensive Care and Pain Medicine, Turku University Hospital and University of Turku, Finland
(författare)
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Maksimow, AnuDepartment of Perioperative Services, Intensive Care and Pain Medicine, Turku University Hospital and University of Turku, Finland
(författare)
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Laitio, TimoDepartment of Perioperative Services, Intensive Care and Pain Medicine, Turku University Hospital and University of Turku, Finland
(författare)
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Revonsuo, AnttiHögskolan i Skövde,Institutionen för biovetenskap,Forskningsmiljön Systembiologi,Department of Psychology and Speech-Language Pathology, and Turku Brain and Mind Center, University of Turku, Finland,Kognitiv Neurovetenskap och Filosofi, Consciousness and Cognitive Neuroscience(Swepub:his)reva
(författare)
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Scheinin, HarryTurku PET Centre, Turku University Hospital and University of Turku, Finland ; Department of Perioperative Services, Intensive Care and Pain Medicine, Turku University Hospital and University of Turku, Finland ; Institute of Biomedicine and Unit of Clinical Pharmacology, University of Turku and Turku University Hospital, Finland
(författare)
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Valli, Katja,1973-Högskolan i Skövde,Institutionen för biovetenskap,Forskningsmiljön Systembiologi,Department of Psychology and Speech-Language Pathology, and Turku Brain and Mind Center, University of Turku, Finland ; Department of Perioperative Services, Intensive Care and Pain Medicine, Turku University Hospital and University of Turku, Finland,Kognitiv Neurovetenskap och Filosofi, Consciousness and Cognitive Neuroscience(Swepub:his)vala
(författare)
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Turku PET Centre, Turku University Hospital and University of Turku, FinlandDepartment of Psychology and Speech-Language Pathology, and Turku Brain and Mind Center, University of Turku, Finland
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Consciousness and Cognition: Elsevier961053-81001090-2376
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Radek, Linda
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Koskinen, Lauri
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Sandman, Nils
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Laaksonen, Lauri
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Kallionpää, Roos ...
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Scheinin, Annalo ...
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visa fler...
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Rajala, Ville
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Maksimow, Anu
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Laitio, Timo
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Revonsuo, Antti
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Scheinin, Harry
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Valli, Katja, 19 ...
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Högskolan i Skövde